Article (Scientific journals)
Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse
ONESTI, Concetta Elisa; JOSSE, Claire; Boulet, Delphine et al.
2020In Oncoimmunology
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Abstract :
[en] Background: Cancer outcome is associated with circulating immune cells, including eosinophils. Here we analyze the relative eosinophil count (REC) in different breast cancer subtypes. Methods: Stage I–III breast cancer patients were included in the study and classified as REC-high vs low (cutoff 1.5%) or relative lymphocyte count (RLC)-high vs low (cutoff 17.5%). The co-primary endpoints were the breast cancer-specific survival (BCSS) or the time to treatment failure (TTF) in the REC groups. Results: Overall 930 patients were included in the study. We observed a benefit for REC-high vs REC-low in TTF (HR 0.610, 95% CI 0.458–0.812), and in BCSS (HR 0.632, 95% CI 0.433–0.923). Similarly, we observed a better TTF (HR 0.421, 95% CI 0.262–0.677) and BCSS (HR 0.350, 95% CI 0.200–0.614) in RLC-high vs low. A lower relapse rate was observed in the REC-high vs REC-low group (17.1% vs 24.7%, p = 0.005), not confirmed in the multivariate analysis. A lower median REC at baseline and at relapse was observed compared to REC after surgery and during cancer-free follow-up (p < .0001). Conclusions: REC could be a new promising, affordable and accessible predictive and prognostic biomarker in all breast cancer subtypes.
Disciplines :
Oncology
Author, co-author :
ONESTI, Concetta Elisa ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
JOSSE, Claire  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
Boulet, Delphine ;  Université de Liège - ULiège > Cancer-Human Genetics
Thiry, Jérôme ;  Université de Liège - ULiège > Cancer-Human Genetics
Beaumecker, Barbara ;  Université de Liège - ULiège > Master méd. (180 crédits)
BOURS, Vincent ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Service de génétique
JERUSALEM, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service d'oncologie médicale
Language :
English
Title :
Blood eosinophilic relative count is prognostic for breast cancer and associated with the presence of tumor at diagnosis and at time of relapse
Publication date :
2020
Journal title :
Oncoimmunology
ISSN :
2162-4011
eISSN :
2162-402X
Publisher :
Landes Bioscience, United States - Pennsylvania
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 June 2020

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