Article (Scientific journals)
Right Atrial Myocardial Remodeling in Children With Atrial Septal Defect Involves Inflammation, Growth, Fibrosis, and Apoptosis.
Rouatbi, Hatem; FARHAT, Nesrine; Heying, Ruth et al.
2020In Frontiers in Pediatrics, 8, p. 40
Peer Reviewed verified by ORBi
 

Files


Full Text
Right atrial myocardial remodeling in children with atrial septal defect involves inflammation, growth, fibrosis and apoptosis.pdf
Publisher postprint (457.01 kB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
apoptosis; atrial septum defect; congenital heart disease; fibrosis; growth; inflammation; myocardial remodeling
Abstract :
[en] Introduction: Myocardial remodeling due to large atrial septum defect (ASD) is macroscopically characterized by dilation of the right-sided cardiac cavities secondary to volume overload, the cellular mechanisms of which are not yet understood. We postulated that inflammation, fibrosis, and cell death are actors of right atrial remodeling secondary to ASD. Patients and Methods: In 12 children with large ASD (median age: 63 months), expression of genes coding for proteins involved in the response to cell stress and -protection, inflammation, growth and angiogenesis, fibrosis, and apoptosis was assessed by RT-PCR in right atrial myocardial biopsies taken during cardiac surgery. The presence of cytokines in myocardial cells was confirmed by immunohistochemistry and effective apoptosis by TUNEL assay. Results: In all patients investigated, a cellular response to early mechanical stress with the initiation of early protective mechanisms, of inflammation (and its control), -growth, and -angiogenesis, of fibrosis and apoptosis was present. The apoptotic index assessed by TUNEL assay averaged 0.3%. Conclusions: In children with large ASD, macroscopic right atrial remodeling relates to cellular mechanisms involving the expression of numerous genes that either still act to protect cells and tissues but that also harm as they initiate and/or sustain inflammation, fibrosis, and cell death by apoptosis. This may contribute to long term morbidity in patients with ASD.
Disciplines :
Cardiovascular & respiratory systems
Pediatrics
Author, co-author :
Rouatbi, Hatem
FARHAT, Nesrine  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
Heying, Ruth
GERARD, Arlette ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
Vazquez-Jimenez, Jaime F.
SEGHAYE, Marie-Christine ;  Centre Hospitalier Universitaire de Liège - CHU > Département de Pédiatrie > Service de pédiatrie
Language :
English
Title :
Right Atrial Myocardial Remodeling in Children With Atrial Septal Defect Involves Inflammation, Growth, Fibrosis, and Apoptosis.
Publication date :
February 2020
Journal title :
Frontiers in Pediatrics
eISSN :
2296-2360
Publisher :
Frontiers Media, Lausanne, Switzerland
Volume :
8
Pages :
40
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2020 Rouatbi, Farhat, Heying, Gerard, Vazquez-Jimenez and Seghaye.
Available on ORBi :
since 03 June 2020

Statistics


Number of views
75 (3 by ULiège)
Number of downloads
37 (1 by ULiège)

Scopus citations®
 
9
Scopus citations®
without self-citations
7
OpenCitations
 
10

Bibliography


Similar publications



Contact ORBi