[en] Nowadays, the use of functionalised surface-enhanced Raman scattering (SERS) substrates has become very common. These surface modifying agents notably act as Raman reporters, as sensors of biological processes (pH, redox probes) or to increase the sensitivity and/or the specificity of SERS detections.
However, the effects of the functionalisation agents are deeply examined in very few studies, even though they can affect the aggregation behaviour of the SERS substrate. Moreover, depending on their concentration and on the pH, their spectral signature can be modified and they can even degrade if stored inappropriately.
In this context, this paper aims at emphasising the importance of the different aspects previously listed in the selection of a functionalisation agent. Pyridine derivatives were picked out to highlight these parameters, as some of these compounds are commonly used to be grafted onto SERS substrates. Two widespread syntheses of nanoparticles were selected as SERS substrates: citrate-reduced gold and silver nanoparticles. The surface of the nanoparticles was functionalised with several pyridine derivatives at different concentrations and in several solvents. It was observed that the molecules under study had a concentration-dependent effect on nanoparticle aggregation. A stability study was furthermore conducted in order to determine the best preservation conditions of the grafting solutions.
In conclusion, this paper shines a light on the relevance of the investigation of the too-often neglected behaviour of the surface modifying agents. Before their application in SERS analyses, parameters such as the label concentration should therefore be included in an experimental design to optimise the sample preparation.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Chemistry Pharmacy, pharmacology & toxicology
Author, co-author :
Dumont, Elodie ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
De Bleye, Charlotte ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Haouchine, Merzouk
Coic, Laureen ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Sacre, Pierre-Yves ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Language :
English
Title :
Effect of the functionalisation agent on the surface-enhanced Raman scattering (SERS) spectrum: Case study of pyridine derivatives
Publication date :
05 June 2020
Journal title :
Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
ISSN :
1386-1425
Publisher :
Elsevier, United Kingdom
Volume :
233
Pages :
118180
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE] FEDER - Fonds Européen de Développement Régional [BE]
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