[en] Malaria is a parasitic disease responsible for thousands of deaths annually. The emergence of resistance to current treatments requires the search for new natural molecules. The development of new anti-malarial drugs focuses on plants origin. As far as it could be established, fungal kingdom is poorly studied for the discovery of antimalarials, compared to the potential that they could have.
In this study, we have selected nine Belgian mushrooms that we collected in Eupen and Theux. We have performed an antiplasmodial screening on two different extracts from these species (MeOH and EtOAc).
Two of them demonstrated weak activity (IC50 < 50 µg/mL) and one of the extract, called GC-B19-04 during the genetic identification demonstrated high activity (IC50 <15).
Bioguided fractionation was undertaken and allowed the isolation of fractions and pure compounds.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Clain, Marie-Elodie ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Gils, Marie ; Université de Liège - ULiège > Master sc. pharma., à fin.
Ledoux, Allison ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Desdemoustier, Pauline ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Turki, Chayma ; Université de Liège - ULiège > Master sc. pharma., à fin.
Jérusalem, Matthieu ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Département de Biologie, Ecologie et Evolution
Frederich, Michel ; Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Castillo Cabello, Gabriel ; Université de Liège - ULiège > Département de Biologie, Ecologie et Evolution > Département de Biologie, Ecologie et Evolution
Language :
English
Title :
Antiplasmodial activity and chemical composition of Belgian mushrooms