Anosognosia and default mode subnetwork dysfunction in Alzheimer's disease

[en] Research on the neural correlates of anosognosia in Alzheimer's disease varied according to methods and objectives: they compared different measures, used diverse neuroimaging modalities, explored connectivity between brain networks, addressed the role of specific brain regions or tried to give support to theoretical models of unawareness. We used resting-state fMRI connectivity with two different seed regions and two measures of anosognosia in different patient samples to investigate consistent modifications of default mode subnetworks and we aligned the results with the Cognitive Awareness Model. In a first study, patients and their relatives were presented with the Memory Awareness Rating Scale. Anosognosia was measured as a patient-relative discrepancy score and connectivity was investigated with a parahippocampal seed. In a second study, anosognosia was measured in patients with brain amyloid (taken as a disease biomarker) by comparing self-reported rating with memory performance, and connectivity was examined with a hippocampal seed. In both studies, anosognosia was consistently related to disconnection within the medial temporal subsystem of the default mode network, subserving episodic memory processes. Importantly, scores were also related to disconnection between the medial temporal and both the core subsystem (participating to self-reflection) and the dorsomedial subsystem of the default mode network (the middle temporal gyrus that might subserve a personal database in the second study). We suggest that disparity in connectivity within and between subsystems of the default mode network may reflect impaired functioning of pathways in cognitive models of awareness. © 2019 The Authors. Human Brain Mapping published by Wiley Periodicals, Inc.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurology

Author, co-author :

Antoine, Nicolas ; Université de Liège - ULiège > Doct. sc. médicales (Bologne)

Bahri, Mohamed Ali ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Bastin, Christine ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Collette, Fabienne ; Université de Liège - ULiège > Département de Psychologie > Neuropsychologie

Phillips, Christophe ; Université de Liège - ULiège > CRC In vivo Im.-Neuroimaging, data acquisition & processing

Balteau, Evelyne ; Université de Liège - ULiège > CRC In vivo Im.-Neuroimaging, data acquisition & processing

Genon, Sarah ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Salmon, Eric ; Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et revalid. cogn.

Language :

English

Title :

Anosognosia and default mode subnetwork dysfunction in Alzheimer's disease

Publication date :

2019

Journal title :

Human Brain Mapping

ISSN :

1065-9471

eISSN :

1097-0193

Publisher :

John Wiley and Sons Inc.

Volume :

Pages :

5330-5340

Peer reviewed :

Peer Reviewed verified by ORBi

Name of the research project :

DFG: GE 2835/1‐1; DFG12/17‐01

Funders :

DFG - Deutsche Forschungsgemeinschaft [DE]
FRB - Fondation Roi Baudouin [BE]

Available on ORBi :

since 19 December 2019

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