Article (Scientific journals)
Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets.
GUIOT, Julien; Struman, Ingrid; Louis, Edouard et al.
2019In Journal of Clinical Medicine, 8 (9)
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Keywords :
acute lung injury/acute respiratory distress syndrome; asthma; chronic obstructive pulmonary disease; diagnostic biomarkers; exosomes; idiopathic pulmonary fibrosis; lung diseases; microRNAs; therapeutics
Abstract :
[en] Increasing evidence suggests the potential role of extracellular vesicles (EVs) in many lung diseases. According to their subcellular origin, secretion mechanism, and size, EVs are currently classified into three subpopulations: exosomes, microvesicles, and apoptotic bodies. Exosomes are released in most biofluids, including airway fluids, and play a key role in intercellular communication via the delivery of their cargo (e.g., microRNAs (miRNAs)) to target cell. In a physiological context, lung exosomes present protective effects against stress signals which allow them to participate in the maintenance of lung homeostasis. The presence of air pollution alters the composition of lung exosomes (dysregulation of exosomal miRNAs) and their homeostatic property. Indeed, besides their potential as diagnostic biomarkers for lung diseases, lung exosomes are functional units capable of dysregulating numerous pathophysiological processes (including inflammation or fibrosis), resulting in the promotion of lung disease progression. Here, we review recent studies on the known and potential role of lung exosomes/exosomal miRNAs, in the maintaining of lung homeostasis on one hand, and in promoting lung disease progression on the other. We will also discuss using exosomes as prognostic/diagnostic biomarkers as well as therapeutic tools for lung diseases.
Disciplines :
Cardiovascular & respiratory systems
Author, co-author :
GUIOT, Julien  ;  Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de pneumologie - allergologie
Struman, Ingrid  ;  Université de Liège - ULiège > Cancer-Molecular Angiogenesis Laboratory
Louis, Edouard  ;  Université de Liège - ULiège > Département des sciences cliniques > Hépato-gastroentérologie
Louis, Renaud ;  Université de Liège - ULiège > Département des sciences cliniques > Pneumologie - Allergologie
Malaise, Michel ;  Université de Liège - ULiège > Département des sciences cliniques > Rhumatologie
Njock, Makon-Sébastien  ;  Université de Liège - ULiège > Cancer-Molecular Angiogenesis Laboratory
Language :
English
Title :
Exosomal miRNAs in Lung Diseases: From Biologic Function to Therapeutic Targets.
Publication date :
2019
Journal title :
Journal of Clinical Medicine
eISSN :
2077-0383
Publisher :
MDPI, Basel, Switzerland
Volume :
8
Issue :
9
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 November 2019

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