Article (Scientific journals)
House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.
Serhan, Nadine; Basso, Lilian; Sibilano, Riccardo et al.
2019In Nature Immunology
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Abstract :
[en] Allergic skin diseases, such as atopic dermatitis, are clinically characterized by severe itching and type 2 immunity-associated hypersensitivity to widely distributed allergens, including those derived from house dust mites (HDMs). Here we found that HDMs with cysteine protease activity directly activated peptidergic nociceptors, which are neuropeptide-producing nociceptive sensory neurons that express the ion channel TRPV1 and Tac1, the gene encoding the precursor for the neuropeptide substance P. Intravital imaging and genetic approaches indicated that HDM-activated nociceptors drive the development of allergic skin inflammation by inducing the degranulation of mast cells contiguous to such nociceptors, through the release of substance P and the activation of the cationic molecule receptor MRGPRB2 on mast cells. These data indicate that, after exposure to HDM allergens, activation of TRPV1(+)Tac1(+) nociceptor-MRGPRB2(+) mast cell sensory clusters represents a key early event in the development of allergic skin reactions.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Serhan, Nadine
Basso, Lilian
Sibilano, Riccardo
Petitfils, Camille
Meixiong, James
Bonnart, Chrystelle
Reber, Laurent L.
Marichal, Thomas  ;  Université de Liège - ULiège > I3-Immunophysiology
Starkl, Philipp
Cenac, Nicolas
Dong, Xinzhong
Tsai, Mindy
Galli, Stephen J.
Gaudenzio, Nicolas
More authors (4 more) Less
Language :
English
Title :
House dust mites activate nociceptor-mast cell clusters to drive type 2 skin inflammation.
Publication date :
2019
Journal title :
Nature Immunology
ISSN :
1529-2908
eISSN :
1529-2916
Publisher :
Nature Publishing Group, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 November 2019

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