Article (Scientific journals)
Les histones desacetylases : nouvelles cibles pour les therapies anti-cancereuses.
Mottet, Denis; Castronovo, Vincenzo
2008In MS. Medecine Sciences, 24 (8-9), p. 742-6
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Keywords :
Antineoplastic Agents/therapeutic use; Apoptosis/drug effects; Cell Division/drug effects; Enzyme Inhibitors/therapeutic use; Histone Deacetylases/antagonists & inhibitors; Humans; Neoplasms/drug therapy/genetics/pathology; Neovascularization, Pathologic/psychology
Abstract :
[en] Circa twenty-five years ago, cancer research was dominated by the concept that the origin of cancer was genetic. Thousands of genetic alterations have indeed been identified involving more than hundred different genes in cancer development. Today, the model has evolved: it has been demonstrated that malignancies can be initiated not only through genetic alterations but also through epigenetic deregulations. By altering the expression of gene involved in cell regulation, epigenetic alterations, such as histone acetylation, play a key role in the initiation and progression of neoplasm. It has been shown that an imbalance between the acelylated and deacetylated status of chromatin is significantly involved in the acquisition of a malignant phenotype. Thus, the modulation of the histone acetylation level by histone deacetylase (HDAC) inhibitors could lead to a genetic re-programmation in cancer cells that would favor apoptosis and prevent proliferation. The potential therapeutic value of several HDAC inhibitors for cancer patients has been evaluated in clinical assays with very promising outcome. Indeed, the first inhibitors available for patients has been recently approved for cancer patients tracing the way for a new class of promising anti-cancer therapy modalities.
Research center :
Giga-Cancer - ULiège
Disciplines :
Biochemistry, biophysics & molecular biology
Oncology
Author, co-author :
Mottet, Denis ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > GIGA-R : Labo de recherche sur les métastases
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire - GIGA-R : Labo de recherche sur les métastases
Language :
French
Title :
Les histones desacetylases : nouvelles cibles pour les therapies anti-cancereuses.
Alternative titles :
[en] Histone deacetylases: a new class of efficient anti-tumor drugs
Publication date :
2008
Journal title :
MS. Medecine Sciences
ISSN :
0767-0974
eISSN :
1958-5381
Publisher :
EDK, Paris, France
Volume :
24
Issue :
8-9
Pages :
742-6
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 September 2009

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