Reference : Small Integrin-Binding Ligand N-Linked Glycoproteins (Siblings): Multifunctional Prot...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Human health sciences : Oncology
Small Integrin-Binding Ligand N-Linked Glycoproteins (Siblings): Multifunctional Proteins in Cancer
Bellahcene, Akeila mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Labo de recherche sur les métastases >]
Castronovo, Vincenzo mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire >]
Ogbureke, K. U. [> > > >]
Fisher, L. W. [> > > >]
Fedarko, N. S. [> > > >]
Nature Reviews. Cancer
Nature Publishing Group
Yes (verified by ORBi)
[en] SIBLINGs ; cancer
[en] Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS ; Centre Anticancéreux près l'Université de Liège ; European Commission (METABRE) ; National Institutes of Health - NIH ; Medical College of Georgia Research Institute Grant ; Wendy Wll Case Cancer Fund ; Intramural Research Program of the NIH, Department of Health and Human Services ; National Cancer Institute ; Department of Defense Congressionally Directed Medical Research Program

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