[en] Numerous components and pathways are involved in the complex interplay between cancer cells and their environment. The family of glycophosphoproteins comprising osteopontin, bone sialoprotein, dentin matrix protein 1, dentin sialophosphoprotein and matrix extracellular phosphoglycoprotein - small integrin-binding ligand N-linked glycoproteins (SIBLINGs) - are emerging as important players in many stages of cancer progression. From their detection in various human cancers to the demonstration of their key functional roles during malignant transformation, invasion and metastasis, the SIBLINGs are proteins with potential as diagnostic and prognostic tools, as well as new therapeutic targets.
Bellahcene, Akeila ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Labo de recherche sur les métastases
Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Ogbureke, K. U.
Fisher, L. W.
Fedarko, N. S.
Language :
English
Title :
Small Integrin-Binding Ligand N-Linked Glycoproteins (Siblings): Multifunctional Proteins in Cancer
Publication date :
March 2008
Journal title :
Nature Reviews. Cancer
ISSN :
1474-175X
eISSN :
1474-1768
Publisher :
Nature Publishing Group
Volume :
8
Issue :
3
Pages :
212-26
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
METABRE
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique CAC - Centre anticancéreux près l'Université de Liège asbl EC - European Commission NIH - National Institutes of Health NIH - National Institutes of Health NCI - National Cancer Institute
Funding text :
Medical College of Georgia Research Institute Grant; Wendy Wll Case Cancer Fund; Department of Defense Congressionally Directed Medical Research Program
