Article (Scientific journals)
Persistent vs Transient Alteration of Folliculogenesis and Estrous Cycle After Neonatal vs Adult Exposure to Bisphenol A.
Lopez Rodriguez, David; Franssen, Delphine; Sevrin, Elena et al.
2019In Endocrinology, 160 (11), p. 2558-2572
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Abstract :
[en] Exposure to bisphenol A (BPA), a ubiquitous endocrine-disrupting chemical (EDC), is known to produce variable effects on female puberty and ovulation. This variability of effects is possibly due to differences in dose and period of exposure. Little is known about the effects of adult exposure to environmentally relevant doses of this EDC and the differences in effect after neonatal exposure. This study sought to compare the effects of neonatal vs adult exposure to a very low dose or a high dose of BPA for 2 weeks on ovulation and folliculogenesis and to explore the hypothalamic mechanisms involved in such disruption by BPA. One-day-old and 90-day-old female rats received daily subcutaneous injections of corn oil (vehicle) or BPA (25 ng/kg/d or 5 mg/kg/d) for 15 days. Neonatal exposure to both BPA doses significantly disrupted the estrous cycle and induced a decrease in primordial follicles. Effects on estrous cyclicity and folliculogenesis persisted into adulthood, consistent with a disruption of organizational mechanisms. During adult exposure, both doses caused a reversible decrease in antral follicles and corpora lutea. A reversible disruption of the estrous cycle associated with a delay and a decrease in the amplitude of the LH surge was also observed. Alterations of the hypothalamic expression of the clock gene Per1 and the reproductive peptide phoenixin indicated a disruption of the hypothalamic control of the preovulatory LH surge by BPA.
Disciplines :
Reproductive medicine (gynecology, andrology, obstetrics)
Author, co-author :
Lopez Rodriguez, David ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Franssen, Delphine ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Sevrin, Elena 
GERARD, Arlette 
BALSAT, Cédric 
Blacher, Silvia ;  Université de Liège - ULiège > Cancer-Tumours and development biology
Noël, Agnès ;  Université de Liège - ULiège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement
Parent, Anne-Simone ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Language :
English
Title :
Persistent vs Transient Alteration of Folliculogenesis and Estrous Cycle After Neonatal vs Adult Exposure to Bisphenol A.
Publication date :
2019
Journal title :
Endocrinology
ISSN :
0013-7227
eISSN :
1945-7170
Publisher :
The Endocrine Society, United States - Maryland
Volume :
160
Issue :
11
Pages :
2558-2572
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2019 Endocrine Society.
Available on ORBi :
since 16 October 2019

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