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Franssen Delphine

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Main Referenced Co-authors
Parent, Anne-Simone  (43)
Bourguignon, Jean-Pierre  (29)
Gerard, Arlette  (28)
Lopez Rodriguez, David  (14)
Hanson, Julien  (9)
Main Referenced Keywords
Animals (5); Female (5); hypothalamus (4); Puberty (3); puberty (3);
Main Referenced Unit & Research Centers
Neuroendocrinology Unit, GIGA-neuroscience (1)
Main Referenced Disciplines
Endocrinology, metabolism & nutrition (35)
Pediatrics (14)
Neurology (4)
Life sciences: Multidisciplinary, general & others (4)
Anatomy (cytology, histology, embryology...) & physiology (3)

Publications (total 52)

The most downloaded
1166 downloads
Lopez Rodriguez, D., Franssen, D., Heger, S., & PARENT, A.-S. (September 2021). Endocrine-disrupting chemicals and their effects on puberty. Best Practice and Research. Clinical Endocrinology and Metabolism, 35 (5), 101579. doi:10.1016/j.beem.2021.101579 https://hdl.handle.net/2268/288347

The most cited

137 citations (Scopus®)

Parent, A.-S., Franssen, D., FUDVOYE, J., GERARD, A., & Bourguignon, J.-P. (2015). Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents. Frontiers in Neuroendocrinology. doi:10.1016/j.yfrne.2014.12.004 https://hdl.handle.net/2268/178663

Franssen, D., & Parent, A.-S. (August 2023). Emulsifiers during gestation: The risks of ultra-processed food revealed in mice. PLoS Biology, 21 (8), 3002265. doi:10.1371/journal.pbio.3002265
Peer Reviewed verified by ORBi

Velasco, I.* , Franssen, D.* , Daza-Dueñas, S., Skrapits, K., Takács, S., Torres, E., Rodríguez-Vazquez, E., Ruiz-Cruz, M., León, S., Kukoricza, K., Zhang, F.-P., Ruohonen, S., Luque-Cordoba, D., Priego-Capote, F., Gaytan, F., Ruiz-Pino, F., Hrabovszky, E., Poutanen, M., Vázquez, M. J., & Tena-Sempere, M. (29 April 2023). Dissecting the KNDy hypothesis: KNDy neuron-derived kisspeptins are dispensable for puberty but essential for preserved female fertility and gonadotropin pulsatility. Metabolism: Clinical and Experimental, 144, 155556. doi:10.1016/j.metabol.2023.155556
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Boberg, J., Johansson, H. K. L., Franssen, D., Draskau, M. K., Christiansen, S., Cramer, J., Pedersen, M., Parent, A.-S., & Svingen, T. (15 January 2023). Exposure to the pesticides linuron, dimethomorph and imazalil alters steroid hormone profiles and gene expression in developing rat ovaries. Toxicology Letters, 373, 114-122. doi:10.1016/j.toxlet.2022.11.010
Peer Reviewed verified by ORBi

Franssen, D., Johansson, H. K. L., Lopez-Rodriguez, D., Lavergne, A., Terwagne, Q., Boberg, J., Christiansen, S., Svingen, T., & Parent, A.-S. (2023). Perinatal exposure to the fungicide ketoconazole alters hypothalamic control of puberty in female rats. Frontiers in Endocrinology, 14, 1140886. doi:10.3389/fendo.2023.1140886
Peer Reviewed verified by ORBi

Delli, V., Dehame, J., Franssen, D., Rasika, S., Parent, A.-S., Prevot, V., & Chachlaki, K. (January 2023). Male minipuberty involves the gonad-independent activation of preoptic nNOS neurons. Free Radical Biology and Medicine, 194, 199-208. doi:10.1016/j.freeradbiomed.2022.11.040
Peer Reviewed verified by ORBi

Franssen, D., Svingen, T., Lopez Rodriguez, D., Van Duursen, M., Boberg, J., & Parent, A.-S. (2022). A putative adverse outcome pathway network for disrupted female pubertal onset to improve testing and regulation of endocrine disrupting chemicals. Neuroendocrinology, 112 (2), 101-114. doi:10.1159/000515478
Peer Reviewed verified by ORBi

Lopez Rodriguez, D., Franssen, D., Heger, S., & PARENT, A.-S. (September 2021). Endocrine-disrupting chemicals and their effects on puberty. Best Practice and Research. Clinical Endocrinology and Metabolism, 35 (5), 101579. doi:10.1016/j.beem.2021.101579
Peer Reviewed verified by ORBi

López-Rodríguez, D., Aylwin, C. F., Delli, V., Sevrin, E., Campanile, M., Martin, M., Franssen, D., Gérard, A., Blacher, S., Tirelli, E., Noël, A., Lomniczi, A., & PARENT, A.-S. (August 2021). Multi- and Transgenerational Outcomes of an Exposure to a Mixture of Endocrine-Disrupting Chemicals (EDCs) on Puberty and Maternal Behavior in the Female Rat. Environmental Health Perspectives, 129 (8), 87003. doi:10.1289/EHP8795
Peer Reviewed verified by ORBi

Lopez Rodriguez, D., Franssen, D., Bakker, J., Lomniczi, A., & Parent, A.-S. (07 February 2021). Cellular and molecular features of EDC exposure: consequences for the GnRH network. Nature Reviews. Endocrinology, 17 (2), 83-96. doi:10.1038/s41574-020-00436-3
Peer Reviewed verified by ORBi

Torres, E., Velasco, I., Franssen, D., Heras, V., Gaytan, F., Leon, S., Navarro, V., Pineda, R., Luz Candenas, M., Romero-Ruiz, A., & Tena-Sempere, M. (2021). Congenital ablation of Tacr2 reveals overlapping and redundant roles of NK2R signaling in the control of reproductive axis. American Journal of Physiology - Endocrinology and Metabolism. doi:10.1152/AJPENDO.00346.2020
Peer Reviewed verified by ORBi

Boberg, J., Johansson, H., Franssen, D., Cramer, J., Usai, D., Pedersen, M., Parent, A.-S., & Svingen, T. (2021). Perinatal exposure to known endocrine disrupters alters ovarian development and systemic steroid hormone profile in rats. Toxicology, 458. doi:10.1016/j.tox.2021.152821
Peer reviewed

Johansson, H., Damdimopoulou, P., van Duursen, M., Boberg, J., Franssen, D., de Cock, M., Jaager, K., Wagner, M., Velthut-Meikas, A., Xie, Y., Connolly, L., Lelandais, P., Mazaud-Guittot, S., Salumet, A., Draskau, M., Filis, P., Fowler, P., Christiansen, S., Parent, A.-S., & Svingen, T. (2020). Putative adverse outcome pathways for female reproductive disorders to improve testing and regulation of chemicals. Archives of Toxicology, 94, 3359-3379. doi:10.1007/s00204-020-02834-y
Peer Reviewed verified by ORBi

Ruiz-Pino, F., Miceli, D., Franssen, D., Vazquez, M.-J., Farinetti, A., Castellano, J., Panzica, G., & Tena-Sempere, M. (25 October 2019). Environmentally Relevant Perinatal Exposures to Bisphenol A Disrupt Postnatal Kiss1/NKB Neuronal Maturation and Puberty Onset in Female Mice. Environmental Health Perspectives, 127 (10). doi:10.1289/EHP5570
Peer Reviewed verified by ORBi

Franssen, D., Lopez Rodriguez, D., Dupuis, N., GERARD, A., Hanson, J., Bourguignon, J.-P., & Parent, A.-S. (September 2019). GPR151, a new regulator of GnRH neurons [Poster presentation]. The European Centre for Reproductive Endocrinology (EUCRE).

FUDVOYE, J., Lopez Rodriguez, D., Franssen, D., & Parent, A.-S. (June 2019). Endocrine disrupters and possible contribution to pubertal changes. Best practice & research. Clinical endocrinology & metabolism, 33 (3), 101300. doi:10.1016/j.beem.2019.101300
Peer reviewed

Franssen, D., Velasco, I., Ruiz-Pino, F., Torres, E., Ruohonen, S., Roa, J., Poutamen, M., & Tena-Sempere, M. (May 2019). Dissecting the roles of KNDy-derived kisspeptins in the control of reproduction: Generation and characterization of the Tac2-specific Kiss1 KO (TaK-KO) mouse [Paper presentation]. The 21st European Congress of Endocrinology.

Lopez Rodriguez, D., Franssen, D., Sevrin, E., GERARD, A., BALSAT, C., Blacher, S., Noël, A., & Parent, A.-S. (2019). Persistent vs Transient Alteration of Folliculogenesis and Estrous Cycle After Neonatal vs Adult Exposure to Bisphenol A. Endocrinology, 160 (11), 2558-2572. doi:10.1210/en.2019-00505
Peer Reviewed verified by ORBi

Franssen, D., Barroso, A., Ruiz-Pino, F., Vazquez, M.-J., Garcia-Galiano, D., Castellano, J., Gaytan, F., Dieguez, C., Pinilla, L., Lopez, M., Roa, J., & Tena-Sempre, M. (2018). Role of AMP-Activated Protein Kinase (AMPK) in GnRH Neurons in the Metabolic Control of Reproduction [Poster presentation]. ICN2018.

Franssen, D., & Tena-Sempere, M. (2018). The Kisspeptin Receptor: A Key G Protein-Coupled Receptor in the Control of the Reproductive Axis. Best Practice and Research. Clinical Endocrinology and Metabolism, 32, 107-123. doi:10.1016/j.beem.2018.01.005
Peer Reviewed verified by ORBi

Franssen, D., Barroso, A., Ruiz-Pino, F., Vazquez, M.-J., Garcia-Galiano, D., Castellano, J., Gaytan, F., Diequez, C., Pinilla, L., Lopez, M., Roa, J., & Tena-Sempere, M. (October 2017). Metabolic regulation of reproductive axis via the energy sensor, AMPK [Poster presentation]. CAJAL Connectomics: from Micro- to Meso- and Macro-Scales cours.

Pinson, A., Franssen, D., Gerard, A., Parent, A.-S., & Bourguignon, J.-P. (September 2017). Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies. Comptes Rendus Biologies, 340 (9-10), 432-438. doi:10.1016/j.crvi.2017.07.006
Peer Reviewed verified by ORBi

Dupuis, N., Laschet, C., Franssen, D., Martyna, S., Gilissen, J., Geubelle, P., Soni, A., Parent, A.-S., Pirotte, B., Chevigné, A., Twizere, J.-C., & Hanson, J. (01 June 2017). Activation of the orphan G protein-coupled receptor GPR27 by surrogate ligands promotes β-arrestin 2 recruitment. Molecular Pharmacology, 91 (6), 595-608. doi:10.1124/mol.116.107714
Peer Reviewed verified by ORBi

Lopez Rodriguez, D., Franssen, D., GERARD, A., BALSAT, C., Blacher, S., Noël, A., Bourguignon, J.-P., & Parent, A.-S. (05 May 2017). Activational and organizational disruption of folliculogenesis and estrous cycle caused by exposure to Bisphenol A (BPA) during early postnatal or adult life [Paper presentation]. Copenhague Workshop on Endocrine Disruptors (COW 2017), Copenhague, Denmark.

Franssen, D., Dupuis, N., Lopez Rodriguez, D., GERARD, A., Hanson, J., Bourguignon, J.-P., & Parent, A.-S. (04 April 2017). Alteration of the neuroendocrine control of puberty after postnatal exposure to Bisphenol A and involvement of GPR151, a potential new regulator of the GnRH network [Paper presentation]. ENDO2017.

Franssen, D., Dupuis, N., Lopez Rodriguez, D., Hanson, J., GERARD, A., Bourguignon, J.-P., & Parent, A.-S. (March 2017). Postnatal exposure to BPA disturbs neuroendocrine control of puberty without affecting Kiss1 system but involves GPR151, a potential new regulator of the GnRH network [Poster presentation]. The 3rd World Conference on Kisspeptin.

Lopez Rodriguez, D., Franssen, D., GERARD, A., Balsat, C., Blacher, S., Noël, A., Bourguignon, J.-P., & Parent, A.-S. (2017). Early postnatal and adult exposure to BPA: activational vs organizational disruption of folliculogenesis and estrous cycle [Paper presentation]. 6e Journées Internationales de Toxicologie.

Franssen, D., Dupuis, N., Lopez Rodriguez, D., GERARD, A., Hanson, J., Bourguignon, J.-P., & Parent, A.-S. (October 2016). Identification of an orphan GPCR, GPR151, as a target of BPA exposure and a potential actor of the GnRH network [Paper presentation]. 41e colloque de la société de Neuroendocrinologie.

Dupuis, N., Franssen, D., Laschet, C., Geubelle, P., Soni, A., Abboud, D., Twizere, J.-C., Pirotte, B., & Hanson, J. (26 September 2016). Small molecule ligands for the orphan GPR27 [Poster presentation]. GLISTEN meeting 2016 in Prague.

Franssen, D. (2016). Perturbation neuroendocrinienne de la maturation sexuelle après exposition postnatale précoce au Diéthylstilbestrol ou au Bisphénol A [Doctoral thesis, Université de Liège]. ORBi-University of Liège. https://orbi.uliege.be/handle/2268/315316

Franssen, D., Dupuis, N., GERARD, A., Hennuy, B., Hanson, J., Bourguinon, J.-P., & Parent, A.-S. (06 March 2016). Disruption of GnRH secretion in peripubertal female rat after early postnatal exposure to Bisphenol A and involvement of GPR151, a potential new GnRH regulator [Poster presentation]. GnRH COST meeting.

Lopez Rodriguez, D., Franssen, D., GERARD, A., Cedric, B., BLACHER, S., Noël, A., Bourguignon, J.-P., & Parent, A.-S. (2016). Activational and organizational disruption of folliculogenesis and estrous cycle after an exposure to Bisphenol A (BPA) during early postnatal or adult window of exposure [Poster presentation]. EURON PhD days.

Lopez Rodriguez, D., Franssen, D., GERARD, A., Cedric, B., BLACHER, S., Noël, A., Bourguignon, J.-P., & PARENT, A.-S. (2016). Adult exposure to BPA causes activational disruption of estrous cycle and folliculogenesis [Paper presentation]. 41ème colloque de la SNE.

Bourguignon, J.-P., Juul, A., Franssen, D., FUDVOYE, J., Pinson, A., & Parent, A.-S. (2016). Contribution of the Endocrine Perspective in the Evaluation of Endocrine Disrupting Chemical Effects: The Case Study of Pubertal Timing. Hormone Research in Paediatrics. doi:10.1159/000442748
Peer Reviewed verified by ORBi

Parent, A.-S., Franssen, D., Fudvoye, J., Pinson, A., & Bourguignon, J.-P. (2016). Current Changes in Pubertal Timing: Revised Vision in Relation with Environmental Factors Including Endocrine Disruptors. Endocrine Development, 29, 174-84. doi:10.1159/000438885
Peer Reviewed verified by ORBi

Franssen, D., GERARD, A., HENNUY, B., Donneau, A.-F., Bourguignon, J.-P., & Parent, A.-S. (2016). Delayed neuroendocrine sexual maturation in female rats after a very low dose of Bisphenol A through altered GABAergic neurotransmission and opposing effects of a high dose. Endocrinology. doi:10.1210/en.2015-1937
Peer Reviewed verified by ORBi

Franssen, D., Dupuis, N., GERARD, A., HENNUY, B., Hanson, J., Bourguignon, J.-P., & Parent, A.-S. (2015). Disruption of Gonadotropin-Releasing Hormone secretion in peripubertal female rat after early postnatal exposure to Bisphenol A and involvement of GPR151, a potential new Gonadotropin-Releasing Hormone regulator [Poster presentation]. Society for Neurosciences (SFN).

Parent, A.-S., Franssen, D., FUDVOYE, J., GERARD, A., & Bourguignon, J.-P. (2015). Developmental variations in environmental influences including endocrine disruptors on pubertal timing and neuroendocrine control: Revision of human observations and mechanistic insight from rodents. Frontiers in Neuroendocrinology. doi:10.1016/j.yfrne.2014.12.004
Peer Reviewed verified by ORBi

Franssen, D., GERARD, A., Hennuy, B., Parent, A.-S., & Bourguignon, J.-P. (2015). Disrupted neuroendocrine control of pubertal timing after early postnatal exposure to a very low dose of BPA through modulation of GABAergic neurotransmission [Poster presentation]. International Meeting Steroids and Nervous System.

Franssen, D., Dupuis, N., GERARD, A., HENNUY, B., Hanson, J., Parent, A.-S., & Bourguignon, J.-P. (2015). Alteration of the neuroendocrine control of puberty after early postnatal exposure to Bisphenol A and involvement of a potential new regulator of GnRH network GPR151 [Poster presentation]. BSN-SNE joint meeting.

Franssen, D., Ioannou, Y. S., Alvarez-Real, A., Gerard, A., Mueller, J. K., Heger, S., Bourguignon, J.-P., & Parent, A.-S. (2014). Pubertal timing after neonatal diethylstilbestrol exposure in female rats: Neuroendocrine vs peripheral effects and additive role of prenatal food restriction. Reproductive Toxicology, (44), 63-72. doi:10.1016/j.reprotox.2013.10.006
Peer Reviewed verified by ORBi

Franssen, D., GERARD, A., Parent, A.-S., & Bourguignon, J.-P. (2014). Opposing dose-related effects of neonatal BPA exposure on female pubertal timing and neuroendocrine control [Poster presentation]. Gordon Conference: Environmental Endocrine Disruptors, Lucca, Italy.

FUDVOYE, J., Franssen, D., Naveau, E., Pinson, A., GERARD, A., BOURGUIGNON, J.-P., & PARENT, A.-S. (2014). LA PERTURBATION ENDOCRINIENNE : entre enjeux de recherche, enjeux de santé publique et enjeux de pratique quotidienne. Revue Médicale de Liège.
Peer reviewed

Parent, A.-S., Pinson, A., Franssen, D., Naveau, E., Chatzi, C., GERARD, A., & Bourguignon, J.-P. (2014). Neuroendocrine Disruption: Effects of endocrine disrupting chemicals on the hippocampus, the cerebral cortex and the hypothalamus [Paper presentation]. Conference of European Comparative Endocrinologists.

Franssen, D., GERARD, A., Hennuy, B., Parent, A.-S., & Bourguignon, J.-P. (2014). Delayed puberty, slowed down GnRH secretion and changed hypothalamic RNA expression after neonatal exposure to a very low environmentally relevant dose of bisphenol A [Poster presentation]. 8th International Conference on Hormones Brain and Behavior.

Franssen, D., GERARD, A., Hennuy, B., Parent, A.-S., & Bourguignon, J.-P. (2014). Opposing dose-related effects of neonatal BPA exposure on female pubertal timing and neuroendocrine control [Paper presentation]. Conference of European Comparative Endocrinologists.

Bourguignon, J.-P., Franssen, D., GERARD, A., Hennuy, B., & Parent, A.-S. (2014). Delayed Puberty, Slowed Down GnRH Secretion and Changed Hypothalamic RNA Expression after Neonatal Exposure to a Very Low Environmentally Relevant Dose of Bisphenol A. Endocrine Reviews.
Peer Reviewed verified by ORBi

Franssen, D., GERARD, A., Parent, A.-S., & Bourguignon, J.-P. (2014). Disrupted neuroendocrine control of pubertal timing after neonatal BPA exposure and potential epigenetic involvement [Poster presentation]. Cost GnRH, Training School CharitéCrossOver.

Franssen, D., GERARD, A., Parent, A.-S., & Bourguignon, J.-P. (2013). Disrupted neuroendocrine control of pubertal timing after neonatal DES and BPA exposure [Poster presentation]. Brain crosstalk in puberty and adolescence (IPSEN).

Franssen, D., Ioannou, Y., Alvarez-Real, A., GERARD, A., Parent, A.-S., & Bourguignon, J.-P. (2013). Effects of neonatal DES and BPA exposure on the timing of female sexual maturation through neuroendocrine disruption [Poster presentation]. GnRH COST meeting : summer school, Prato, Italy.

Franssen, D., Ioannou, Y., Alvarez-Real, A., GERARD, A., Parent, A.-S., & Bourguignon, J.-P. (2013). Effects of neonatal DES and BPA exposure on the timing of female sexual maturation through neuroendocrine disruption [Paper presentation]. EURON.

Bourguignon, J.-P., Franssen, D., GERARD, A., Pinson, A., Naveau, E., & Parent, A.-S. (2013). Early neuroendocrine disruption in hypothalamus and hippocampus: developmental effects including female sexual maturation and implications for endocrine disrupting chemicals screening. Journal of Neuroendocrinology, 25, 1079-1087. doi:10.1111/jne.12107
Peer Reviewed verified by ORBi

Franssen, D., Ioannou, Y., Alvarez-Real, A., GERARD, A., Parent, A.-S., & BOURGUIGNON, J.-P. (2012). Opposing dose related effects of neonatal DES and BPA exposure on the timing of female sexual maturation through neuroendocrine disruption [Poster presentation]. Programme National de Recherche sur les Perturbateurs Endocriniens (PNRPE).

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