Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

[en] During corticogenesis, distinct subtypes of neurons are sequentially born from ventricular zone progenitors. How these cells are molecularly temporally patterned is poorly understood. We used single-cell RNA sequencing at high temporal resolution to trace the lineage of the molecular identities of successive generations of apical progenitors (APs) and their daughter neurons in mouse embryos. We identified a core set of evolutionarily conserved, temporally patterned genes that drive APs from internally driven to more exteroceptive states. We found that the Polycomb repressor complex 2 (PRC2) epigenetically regulates AP temporal progression. Embryonic age-dependent AP molecular states are transmitted to their progeny as successive ground states, onto which essentially conserved early postmitotic differentiation programs are applied, and are complemented by later-occurring environment-dependent signals. Thus, epigenetically regulated temporal molecular birthmarks present in progenitors act in their postmitotic progeny to seed adult neuronal diversity.

Disciplines :

Genetics & genetic processes

Author, co-author :

Telley, L. ^✱

Agirman, Gulistan ^✱; Université de Liège - ULiège > Neurosciences-Molecular Regulation of Neurogenesis

Prados, J.

Amberg, N.

Fievre, S.

Oberst, P.

Bartolini, G.

Vitali, I.

Cadilhac, C.

Hippenmeyer, S.

More authors (3 more)

^✱ These authors have contributed equally to this work.

Language :

English

Title :

Temporal patterning of apical progenitors and their daughter neurons in the developing neocortex.

Publication date :

2019

Journal title :

Science

ISSN :

0036-8075

eISSN :

1095-9203

Publisher :

American Association for the Advancement of Science, Washington, United States - District of Columbia

Volume :

364

Issue :

6440

Peer reviewed :

Peer Reviewed verified by ORBi

Commentary :

Available on ORBi :

since 23 September 2019

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Scopus citations^®

221

Scopus citations^®
without self-citations

198

OpenCitations

227

OpenAlex citations

340

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