Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load

[en] We investigated whether cognitive fitness in late midlife is associated with physiological and psychological factors linked to increased risk of age-related cognitive decline. Eighty-one healthy late middle-aged participants (mean age: 59.4 y; range: 50-69 y) were included. Cognitive fitness consisted of a composite score known to be sensitive to early subtle cognitive change. Lifestyle factors (referenced below as cognitive reserve factors; CRF) and affective state were determined through questionnaires, and sleep-wake quality was also assessed through actimetry. Allostatic load (AL) was determined through a large range of objective health measures. Generalized linear mixed models, controlling for sex and age, revealed that higher cognitive reserve and lower allostatic load are related to better cognitive efficiency. Crystallized intelligence, sympathetic nervous system functioning and lipid metabolism were the only sub-fields of CRF and AL to be significantly associated with cognition. These results show that previous lifestyle characteristics and current physiological status are simultaneously explaining variability in cognitive abilities in late midlife. Results further encourage early multimodal prevention programs acting on both of these modifiable factors to preserve cognition during the aging process.

Research center :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Neurosciences & behavior

Author, co-author :

Narbutas, Justinas ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Van Egroo, Maxime ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Chylinski, Daphné ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Villar Gonzalez, Pamela ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Garcia Jimenez, Claudia ; Université de Liège - ULiège > Master sc. psycho., à fin.

Besson, Gabriel ; Université de Liège - ULiège > CRC In vivo Imaging-Aging & Memory

Ghaemmaghami Tabrizi, Pouya ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Hammad, Grégory ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Muto, Vincenzo ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

Schmidt, Christina ; Université de Liège - ULiège > CRC In vivo Imaging-Sleep and chronobiology

More authors (6 more)

Language :

English

Title :

Cognitive efficiency in late midlife is linked to lifestyle characteristics and allostatic load

Publication date :

2019

Journal title :

Aging

ISSN :

0002-0966

Publisher :

U.S. Administration on Aging. Department of Health and Human Services, Washington, United States - District of Columbia

Volume :

Pages :

7169-7186

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRSM - Fonds de la Recherche Scientifique Médicale [BE]
FWB - Fédération Wallonie-Bruxelles [BE]
ULiège - Université de Liège [BE]
Fondation Pierre et Simone Clerdent [BE]
FEDER - Fonds Européen de Développement Régional [BE]

Available on ORBi :

since 26 August 2019

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