Article (Scientific journals)
Ferlin overview: from membrane to cancer biology
Peulen, Olivier; Rademaker, Gilles; Anania, Sandy et al.
2019In Cells, 8, p. 954
Peer Reviewed verified by ORBi
 

Files


Full Text
Cells 2019 Peulen.pdf
Publisher postprint (3.32 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
ferlin; myoferlin; dysferlin; otoferlin; C2 domain; plasma membrane
Abstract :
[en] In mammal myocytes, endothelial cells, and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. Membrane biology is of extreme importance for cell survival and signalling, making Ferlin proteins core machinery indispensable for cancer cell adaptation to hostile environment. Expression of several Ferlin genes was described as altered in several cancer types. Among them myoferlin was recently discovered as highly expressed in several tumoural tissues, and negatively correlated to patient survival. Evidences suggest that myoferlin, when overexpressed, enhances cancer cell proliferation, migration and metabolism by affecting various aspects of membrane biology. Targeting myoferlin using pharmacological compounds, gene transfer technology, or interfering RNA is now considered as an emerging therapeutic strategy.
Research center :
Giga-Cancer - ULiège
d‐BRU - Dental Biomaterials Research Unit - ULiège [BE]
Disciplines :
Oncology
Author, co-author :
Peulen, Olivier  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques
Rademaker, Gilles  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Anania, Sandy  ;  Université de Liège - ULiège > Cancer-Metastases Research Laboratory
Turtoi, Andrei 
Bellahcene, Akeila ;  Université de Liège - ULiège > Cancer-Metastases Research Laboratory
Castronovo, Vincenzo ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire
Language :
English
Title :
Ferlin overview: from membrane to cancer biology
Publication date :
August 2019
Journal title :
Cells
eISSN :
2073-4409
Publisher :
Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland
Special issue title :
Killing Cancer: Discovery and Selection of New Target Molecules
Volume :
8
Pages :
954
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
Fonds Léon Fredericq [BE]
ULiège - Université de Liège [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
Available on ORBi :
since 21 August 2019

Statistics


Number of views
104 (23 by ULiège)
Number of downloads
82 (12 by ULiège)

Scopus citations®
 
16
Scopus citations®
without self-citations
14
OpenCitations
 
15

Bibliography


Similar publications



Contact ORBi