Ferlin overview: from membrane to cancer biology

[en] In mammal myocytes, endothelial cells, and inner ear cells, ferlins are proteins involved in membrane processes such as fusion, recycling, endo- and exocytosis. They harbour several C2 domains allowing their interaction with phospholipids. Membrane biology is of extreme importance for cell survival and signalling, making Ferlin proteins core machinery indispensable for cancer cell adaptation to hostile environment. Expression of several Ferlin genes was described as altered in several cancer types. Among them myoferlin was recently discovered as highly expressed in several tumoural tissues, and negatively correlated to patient survival. Evidences suggest that myoferlin, when overexpressed, enhances cancer cell proliferation, migration and metabolism by affecting various aspects of membrane biology. Targeting myoferlin using pharmacological compounds, gene transfer technology, or interfering RNA is now considered as an emerging therapeutic strategy.

Research Center/Unit :

Giga-Cancer - ULiège
d‐BRU - Dental Biomaterials Research Unit - ULiège

Disciplines :

Oncology

Author, co-author :

Peulen, Olivier ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Rademaker, Gilles ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire

Anania, Sandy ; Université de Liège - ULiège > Cancer-Metastases Research Laboratory

Turtoi, Andrei

Bellahcene, Akeila ; Université de Liège - ULiège > Cancer-Metastases Research Laboratory

Castronovo, Vincenzo ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie générale et cellulaire

Language :

English

Title :

Ferlin overview: from membrane to cancer biology

Publication date :

August 2019

Journal title :

Cells

eISSN :

2073-4409

Publisher :

Multidisciplinary Digital Publishing Institute (MDPI), Basel, Switzerland

Special issue title :

Killing Cancer: Discovery and Selection of New Target Molecules

Volume :

Pages :

954

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

Fonds Léon Fredericq
ULiège - Université de Liège
F.R.S.-FNRS - Fonds de la Recherche Scientifique
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture

Available on ORBi :

since 21 August 2019

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