[en] Synthesis of peptides requires addition of amino-acid residue through liquid and solid phase process using coupling reagents such as salts of hydroxybenzotriazole (HOBt). The uronium compound TBTU (2-(1H-benzotriazol-1-y1)-1,1,3,3-tetramethyluronium hexafluorophophate) provide efficient incorporation of amino acids minimizing racemization.
Disciplines :
Dermatology
Author, co-author :
DEZFOULIAN, Bita ; Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de dermatologie
VANDEPLAS, O; Clinique Universitaire de Mont Godinne > pneumologie
HERENG, P
HEYMANS, J; Université Catholique de Louvain - UCL > Toxicologie
LILET-LECLERCQ; Université de Liège - ULiège > ENT
THIMPONT, J; Funds of Occupational Diseases
Language :
English
Title :
Peptite-coupling reagent causing cutaneous and respiratory reactions: multidisciplinary investigation
