[en] In this communication, we will report the development of a capillary electrophoresis approach for the screening of fragments towards thrombin and FXIIa. We performed direct and competitive ACE-binding assays for the screening of molecules at physiological pH.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège NAmur Research Institute for Life - NARILIS
Disciplines :
Pharmacy, pharmacology & toxicology Chemistry
Author, co-author :
Davoine, Clara ; Université de Liège - ULiège / Université de Namur - UNamur > Département de pharmacie > Analyse des médicaments / Namur Medicine & Drug Innovation Center (NAMEDIC – NARILIS) > Doct. sc. bioméd. & pharma. (paysage)
Farcas, Elena ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Bouckaert, Charlotte; Université de Namur - UNamur > Département de pharmacie > Namur Medicine & Drug Innovation Center (NAMEDIC – NARILIS)
Pochet, Lionel; Université de Namur - UNamur > Département de pharmacie > Namur Medicine & Drug Innovation Center (NAMEDIC – NARILIS)
Fillet, Marianne ; Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Development of capillary electrophoresis bioassays for the screening of fragments : application to thrombin and FXIIa
Publication date :
23 November 2018
Event name :
Annual One-Day Symposium on Medicinal Chemistry of SRC & KVCV (Medchem 2018)
Event place :
Namur, Belgium
Event date :
23 novembre 2018
Peer reviewed :
Peer reviewed
Name of the research project :
Development of new compounds targeting coagulation factor XIIa using innovative microfluidic assays in the context of fragment-based drug discovery
Funders :
Fédération Wallonie Bruxelles. Fonds de la Recherche Scientifique - F.R.S.-FNRS
