Article (Scientific journals)
Platelet-rich plasma (PRP) and tendon healing: comparison between fresh and frozen-thawed PRP
KAUX, Jean-François; Libertiaux, Vincent; Dupont, Laura et al.
2020In Platelets, 31 (2), p. 221-225
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Keywords :
Fresh PRP; frozen-thawed PRP; growth factors; platelet; platelet-rich plasma; preservation
Abstract :
[en] Platelet-rich plasma (PRP) is increasingly used in the treatment of musculoskeletal diseases. Its preservation by freezing it for the realization of multiple injections in clinical use has never been discussed. Calcaneal tendons of rats were surgically sectioned. Platelet concentration of the PRP was 2.5 x 106/μl with autologous plasma of rats. Frozen-thawed PRP was prepared by performing two cycles of freezing and thawing on PRP aliquots. Both platelet preparations were injected in the lesion. Biomechanical and histological evaluations were carried out after 7, 20 or 40 days post surgery. After 7 and 40 days, no significant difference was observed between the PRP and the frozen-thawed PRP group. There is however a difference 20 days after surgery: the ultimate tensile strength (UTS) was greater in the fresh PRP group. No obvious difference with histological aspect was observed between the two groups. In conclusion, fresh PRP and frozen-thawed PRP injections can lead to similar results in the healing process of section calcaneal tendons of rats. Improvements with fresh PRP are slight. PRP could thus be frozen to be preserved if multiple injections are needed (e.g. osteoarthritis).
Disciplines :
Orthopedics, rehabilitation & sports medicine
Author, co-author :
KAUX, Jean-François  ;  Centre Hospitalier Universitaire de Liège - CHU > Autres Services Médicaux > Service de médecine de l'appareil locomoteur
Libertiaux, Vincent
Dupont, Laura ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Colige, Alain ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratoire des tissus conjonctifs
Denoël, Vincent  ;  Université de Liège - ULiège > Département ArGEnCo > Analyse sous actions aléatoires en génie civil
LECUT, Christelle ;  Centre Hospitalier Universitaire de Liège - CHU > Unilab > Unité de laboratoire - thrombose - hémostase
Hego, Alexandre ;  Université de Liège - ULiège > Platform Imaging & Flow cytometry
Gustin, Maxime ;  Université de Liège - ULiège > Cardiovascular Sciences-Cardiology
Duwez, Luc ;  Université de Liège - ULiège > GIGA Research (AFT)
Oury, Cécile  ;  Université de Liège - ULiège > Cardiovascular Sciences-Cardiology
Gothot, André ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie de la coagulation et de l'hémostase
Greimers, Laura
Drion, Pierre ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Méth. expér. des anim. de labo et éthique en expér. anim.
More authors (3 more) Less
Language :
English
Title :
Platelet-rich plasma (PRP) and tendon healing: comparison between fresh and frozen-thawed PRP
Publication date :
February 2020
Journal title :
Platelets
ISSN :
0953-7104
eISSN :
1369-1635
Publisher :
Taylor & Francis, United Kingdom
Volume :
31
Issue :
2
Pages :
221-225
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 27 March 2019

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