Extracorporeal CO2 removal and regional citrate anticoagulation in an experimental model of hypercapnic acidosis.

[en] Low flow extracorporeal veno-venous CO2 removal (ECCO2 R) therapy is used to remove CO2 while reducing ventilation intensity. However, the use of this technique is limited because efficiency of CO2 removal and potential beneficial effects on pulmonary hemodynamics are not precisely established. Moreover, this technique requires anticoagulation that may induce severe complications in critically ill patients. This study aimed at determining precisely efficiency of CO2 extraction and its effects on right ventricular (RV) afterload, and comparing regional anticoagulation with citrate to systemic heparin anticoagulation during ECCO2 R. ECCO2 R was highly efficient to normalize pH and PaCO2 and to reduce RV afterload resulting from hypercapnic acidosis. Regional anticoagulation with citrate solution was as effective as standard heparin anticoagulation but did not improve CO2 removal and lead to more hypocalcemia and hypotension.

Disciplines :

Anesthesia & intensive care

Author, co-author :

Morimont, Philippe ; Université de Liège - ULiège > Département des sciences de la santé publique > Département des sciences de la santé publique

Habran, Simon; Université de Liège - ULiège > Faculté des Sciences

Desaive, Thomas ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

BLAFFART, Francine ; Centre Hospitalier Universitaire de Liège - CHU > Département infirmier > Bloc opératoire chirurgie cardio-vasculaire (+1BC)

LAGNY, Marc-Gilbert ; Centre Hospitalier Universitaire de Liège - CHU > Département infirmier > Bloc opératoire chirurgie cardio-vasculaire (+1BC)

AMAND, Théophile ; Centre Hospitalier Universitaire de Liège - CHU > Département infirmier > Bloc opératoire chirurgie cardio-vasculaire (+1BC)

Dauby, Pierre ; Université de Liège - ULiège > Département d'astrophys., géophysique et océanographie (AGO) > Thermodynamique des phénomènes irréversibles

Oury, Cécile ; Université de Liège - ULiège > Cardiovascular Sciences-Cardiology

LANCELLOTTI, Patrizio ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Service de cardiologie

Hego, Alexandre ; Université de Liège - ULiège > Cardiovascular Sciences-Cardiology

Defraigne, Jean-Olivier ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique

LAMBERMONT, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Unité des soins intensifs médicaux

Language :

English

Title :

Extracorporeal CO2 removal and regional citrate anticoagulation in an experimental model of hypercapnic acidosis.

Publication date :

31 January 2019

Journal title :

Artificial Organs

ISSN :

0160-564X

eISSN :

1525-1594

Publisher :

Blackwell, Oxford, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 February 2019

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