Article (Scientific journals)
Evaluation of a new fine-mapping method exploiting linkage disequilibrium: a case study analysing a QTL with major effect on milk composition on bovine chromosome 14
Kim, J. J.; Georges, Michel
2002In Asian-Australasian Journal of Animal Sciences, 15 (9), p. 1250-1256
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Keywords :
linkage mapping; linkage disequilibrium mapping; QTL; milk production traits; dairy cattle
Abstract :
[en] A novel fine-mapping method exploiting linkage disequilibrium (LD) was applied to better refine the quantitative trait loci (QTL) positions for milk production traits on bovine chromosome 14 in the pedigree comprising 22 paternal half-sib families of a Black-and-White Holstein-Friesian grand-daughter design in the Netherlands for a total of 1,034 sons. The chromosome map was constructed with the 31 genetic markers spanning 90 Kosambi cM with the average inter-marker distance of 3.5 cM. The linkage analyses, in which the effects of sire QTL alleles were assumed random and the random factor of the QTL allelic effects was incorporated into the Animal Model, found the QTL for milk, fat, and protein yield and fat and protein % with the Lod scores of 10.9. 2.3, 6.0, 25.4 and 3.2, respectively. The joint analyses including LD information by use of multi-marker haplotypes highly increased the evidence of the QTL (Lod scores were 25.1, 20.9, 11.0, 85.7 and 17.4 for the corresponding traits, respectively). The joint analyses including DGAT markers in the defined haplotypes again increased the QTL evidence and the most likely QTL positions for the five traits coincided with the position of the DGAT gene, supporting the hypothesis of the direct causal involvement of the DGAT gene. This study strongly indicates that the exploitation of LD information will allow additional gains of power and precision in finding and localising QTL of interest in livestock species, on the condition of high marker density around the QTL region.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Kim, J. J.
Georges, Michel  ;  Université de Liège - ULiège > Département de productions animales > Génomique animale
Language :
English
Title :
Evaluation of a new fine-mapping method exploiting linkage disequilibrium: a case study analysing a QTL with major effect on milk composition on bovine chromosome 14
Publication date :
01 January 2002
Journal title :
Asian-Australasian Journal of Animal Sciences
ISSN :
1011-2367
eISSN :
1976-5517
Publisher :
Asian-Australasian Assoc Animal Production Societies, Suwon, South Korea
Volume :
15
Issue :
9
Pages :
1250-1256
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 28 January 2019

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