Article (Scientific journals)
Evaluation of comprehensive two-dimensional gas chromatography coupled to rapid scanning quadrupole mass spectrometry for quantitative analysis
Silva, B. J. G.; Tranchida, P. Q.; Purcaro, Giorgia et al.
2012In Journal of Chromatography. A, 1255, p. 177-183
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Keywords :
Comprehensive two-dimensional gas chromatography; GC×GC; Pesticide; QMS; Quantification; Analytes; Coefficient of variation; Complex samples; Dimension analysis; Extracted ion chromatogram; Mass spectra; Number of datum; Peak capacity; Pesticide residue; Quadrupole mass spectrometer; Quadrupole mass spectrometry; Rapid acquisition; Scan mode; Separation and identification; Chromatographic analysis; Chromatography; Mass spectrometers; Mass spectrometry; Pesticides; Smoke detectors; Quality control; Gas Chromatography-Mass Spectrometry; Linear Models; Lycopersicon esculentum; Pesticide Residues; Reproducibility of Results; Sensitivity and Specificity
Abstract :
[en] Comprehensive two-dimensional gas chromatography (GC. × GC) is a powerful technique that provides excellent separation and identification of analytes in highly complex samples with considerable increase in GC peak capacities. However, since second dimension analyses are very fast, detectors with a rapid acquisition rate are required. Over the last years, quite a number of studies have discussed the potential and limitations of the combination GC. × GC with a variety of quadrupole mass spectrometers. The present research focuses on the evaluation of qMS effectiveness at a 10,000-amu/s scan speed and 20-Hz scan frequency for the identification (full scan mode acquisition-TIC) and quantification (extracted ion chromatogram) of target pesticide residues in tomato samples. The following MS parameters have been evaluated: number of data points per peak, mass spectrum quality, peak skewing, and sensitivity. The validated proposed GC. × GC/qMS method presented satisfactory results in terms of repeatability (coefficient of variation lower than 15%), accuracy (84-117%), and linearity (ranging from 25 to 500. ng/g), while significant enhancement in sensitivity was observed (a factor of around 10) under scan conditions. © 2012 Elsevier B.V.
Disciplines :
Chemistry
Food science
Author, co-author :
Silva, B. J. G.;  Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, SP, Brazil
Tranchida, P. Q.;  Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Viale Annunziata, 98168 Messina, Italy
Purcaro, Giorgia  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Queiroz, M. E. C.;  Departamento de Química, Faculdade de Filosofia Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-901, SP, Brazil
Mondello, L.;  Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Viale Annunziata, 98168 Messina, Italy
Lanças, F. M.;  Instituto de Química de São Carlos, Universidade de São Paulo, São Carlos 13560-970, SP, Brazil
Language :
English
Title :
Evaluation of comprehensive two-dimensional gas chromatography coupled to rapid scanning quadrupole mass spectrometry for quantitative analysis
Publication date :
2012
Journal title :
Journal of Chromatography. A
ISSN :
0021-9673
eISSN :
1873-3778
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
1255
Pages :
177-183
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 January 2019

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