Modeling the interactions between stimulation and physiologically induced APs in a mammalian nerve fiber: dependence on frequency and fiber diameter

Sadashivaiah, Vijay; Sacré, Pierre; Guan, Yun; Anderson, William S.; Sarma, Sridevi V.

doi:10.1007/s10827-018-0703-y

Article (Scientific journals)

Modeling the interactions between stimulation and physiologically induced APs in a mammalian nerve fiber: dependence on frequency and fiber diameter

Sadashivaiah, Vijay; Sacré, Pierre; Guan, Yun et al.

2018 • In Journal of Computational Neuroscience

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/229681

DOI
10.1007/s10827-018-0703-y

PubMed
30443813

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Abstract :

[en] Electrical stimulation of nerve fibers is used as a therapeutic tool to treat neurophysiological disorders. Despite efforts to model the effects of stimulation, its underlying mechanisms remain unclear. Current mechanistic models quantify the effects that the electrical field produces near the fiber but do not capture interactions between action potentials (APs) initiated by stimulus and APs initiated by underlying physiological activity. In this study, we aim to quantify the effects of stimulation frequency and fiber diameter on AP interactions involving collisions and loss of excitability. We constructed a mechanistic model of a myelinated nerve fiber receiving two inputs: the underlying physiological activity at the terminal end of the fiber, and an external stimulus applied to the middle of the fiber. We define conduction reliability as the percentage of physiological APs that make it to the somatic end of the nerve fiber. At low input frequencies, conduction reliability is greater than 95% and decreases with increasing frequency due to an increase in AP interactions. Conduction reliability is less sensitive to fiber diameter and only decreases slightly with increasing fiber diameter. Finally, both the number and type of AP interactions significantly vary with both input frequencies and fiber diameter. Modeling the interactions between APs initiated by stimulus and APs initiated by underlying physiological activity in a nerve fiber opens opportunities towards understanding mechanisms of electrical stimulation therapies.

Disciplines :

Engineering, computing & technology: Multidisciplinary, general & others

Author, co-author :

Sadashivaiah, Vijay

Sacré, Pierre ; Université de Liège - ULiège > Dép. d'électric., électron. et informat. (Inst.Montefiore) > Robotique intelligente

Guan, Yun

Anderson, William S.

Sarma, Sridevi V.

Language :

English

Title :

Modeling the interactions between stimulation and physiologically induced APs in a mammalian nerve fiber: dependence on frequency and fiber diameter

Publication date :

November 2018

Journal title :

Journal of Computational Neuroscience

ISSN :

0929-5313

eISSN :

1573-6873

Publisher :

Kluwer Academic Publishers, Netherlands

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 26 November 2018

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