A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis

Comblain, Fanny; Barthelemy, Nicolas; Lefebvre, Michaël; Schwartz, Cédric; Lesponne, I.; Serisier, S.; Feugier, A.; Balligand, Marc; Henrotin, Yves

doi:10.1186/s12917-017-1317-8

Article (Scientific journals)

A randomized, double-blind, prospective, placebo-controlled study of the efficacy of a diet supplemented with curcuminoids extract, hydrolyzed collagen and green tea extract in owner's dogs with osteoarthritis

Comblain, Fanny; Barthelemy, Nicolas; Lefebvre, Michaël et al.

2017 • In BMC Veterinary Research, 13, p. 395

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/229018

DOI
10.1186/s12917-017-1317-8

PubMed
29262825

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Keywords :

Curcumin; Diet; Dog; Green tea polyphenols; Hydrolyzed collagen; Osteoarthritis; Article

Abstract :

[en] Background: We have previously demonstrated that a mixture of Curcuminoids extract, hydrolyzed COllagen and green Tea extract (CCOT) inhibited inflammatory and catabolic mediator's synthesis by bovine and human chondrocytes. A randomly allocated, double-blind, prospective, placebo-controlled study was performed to evaluate the efficacy of a diet containing this CCOT mixture on dogs with naturally occurring osteoarthritis (OA). Therefore, 42 owner's dogs with OA were randomly assigned to receive for 3months an experimental diet (control) or the same diet supplemented with CCOT. Results: Ground reaction forces did not show statistical differences between groups. After 3months of feeding, there was a significant reduction of pain at manipulation in the CCOT group, but not in the control group. The evolution for pain at manipulation depended on the diet. The three other parameters evaluated by veterinary subjective assessment (lameness, pain at palpation and joint mobility) did not show statistical differences. Concerning owner subjective assessment, pain severity score worsened in the control group but remained stable in CCOT group. The evolution for pain severity depended on the diet. No statistical difference was found for pain interference, except for the ability to rise to standing from lying down, which was significantly improved in the CCOT compared to the control group. Serum OA biomarkers did not show statistical differences. Conclusions: Objective variables measured, such as ground reaction forces and OA biomarkers, did not show statistical differences. However, indicators of pain appeared reduced in dogs receiving CCOT mixture for 3months. The difference of evolution between groups suggests that a greater number of dogs may be necessary to reach a stronger effect on other parameters. © 2017 The Author(s).

Disciplines :

Rheumatology

Author, co-author :

Comblain, Fanny ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Barthelemy, Nicolas ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Chirurgie et clinique chirurgicale des petits animaux

Lefebvre, Michaël ; Université de Liège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Chirurgie et clinique chirurgicale des petits animaux

Schwartz, Cédric ; Université de Liège - ULiège > Département des sciences de la motricité > Kinésithérapie générale et réadaptation

Lesponne, I.; Royal Canin Research Center, Aimargues, France

Serisier, S.; Royal Canin Research Center, Aimargues, France

Feugier, A.; Royal Canin Research Center, Aimargues, France

Balligand, Marc ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Chirurgie et clinique chirurgicale des petits animaux

Henrotin, Yves ; Université de Liège - ULiège > Département des sciences de la motricité > Unité de recherche sur l'os et le cartilage (U.R.O.C.)

Language :

English

Title :

Publication date :

2017

Journal title :

BMC Veterinary Research

eISSN :

1746-6148

Publisher :

BioMed Central Ltd.

Volume :

Pages :

395

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

SAS, School of Arts and Sciences, University of Pennsylvania

Available on ORBi :

since 01 November 2018

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