Reference : Relationship between cerebral amyloid burden and cerebral microstructure measured by ...
Scientific congresses and symposiums : Paper published in a journal
Social & behavioral sciences, psychology : Neurosciences & behavior
http://hdl.handle.net/2268/227994
Relationship between cerebral amyloid burden and cerebral microstructure measured by quantitative MRI in healthy aging
English
Villar Gonzalez, Pamela mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
Chylinski, Daphné mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Narbutas, Justinas mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Van Egroo, Maxime mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Cerasuolo, Mariangela mailto [Seconda Università degli Studi di Napoli > Dipartimento di Psicologia > > >]
Besson, Gabriel mailto [Université de Liège - ULiège > GIGA-CRC In Vivo Imaging > > >]
Ghaemmaghami Tabrizi, Pouya mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Collette, Fabienne mailto [Université de Liège - ULiège > Département de Psychologie > Neuropsychologie >]
SALMON, Eric mailto [Centre Hospitalier Universitaire de Liège - CHU > Département de médecine interne > Centre de jour interdisciplinaire des troubles de la mémoire >]
Baquero Duarte, Katherine Andrea mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie du système nerveux >]
Balteau, Evelyne mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Vandewalle, Gilles mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Phillips, Christophe mailto [Université de Liège - ULiège > > GIGA-CRC In vivo Imaging >]
Bastin, Christine mailto [Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn. >]
22-Aug-2018
Frontiers
Academy of Natural Sciences of Philadelphia
Brain Belgian Congress 2018
Yes (verified by ORBi)
No
International
0016-2159
Philadelphia
PA
Belgian Brain Congress 2018
19-10-2018
Belgian Brain Council
Liège
Bélgica
[en] Aging ; quantitative MRI (qMRI) ; multiparameter mapping, myelin ; Brain iron ; amyloid burden
[en] The presence of Alzheimer’s disease (AD) biomarkers in the brain of healthy older individuals has been associated with decreased myelin and increased iron deposits in the brain (Bartzokis, 2011). Novel Magnetic Resonance Imaging (MRI) techniques, like quantitative multiparameter mapping (MPM), allow to gain insight in the microstructure of the brain and could help to address the link between myelin and iron in the brain (Callaghan et al., 2014) and AD biomarkers. Our aim was, therefore, to relate the amount of myelin and iron content to the cortical amyloid burden. We acquired MPM sequences in a 3T scanner and [18F]flutemetamol positron-emission tomography (PET) images in 55 cognitively healthy adults (35 women), aged 50-70 (mean: 59.5 ± 5.5). We used MPM to infer myelin content, based on magnetization transfer saturation (MT) and longitudinal relaxation rate (R1), and iron content, based on effective transverse relaxation rate (R2*). Cortical beta-amyloid burden was measured with [18F]flutemetamol PET. Multiparameter maps were created and normalised with the hMRI (Balteau et al., 2018) toolbox for MATLAB (The Mathworks Inc, Natick, MA, USA). Correlations between MPM maps and amyloid burden were conducted with SPM12 framework (Wellcome Trust Centre for Neuroimaging, London) p<.05 FWE corrected.
As expected (Dean et al., 2017), we observed a link between increased amyloid burden and increased iron content in frontal areas mainly but also in parietal and occipital areas. However, there was an unexpected negative correlation between amyloid burden and white matter iron content in the left superior temporal area. Moreover, a positive association between amyloid burden and myelin content was found in the frontal and temporal lobes in both grey and white matter. Furthermore, R1 values, which depend on both iron and myelin storage, present positive correlations with amyloid burden in both grey and white matter of frontal, temporal and occipital areas.
The finding that increased iron in frontoparietal and occipital areas are associated with increased amyloid burden fits with previous studies. However, current results also indicate that individuals with higher cortical amyloid burden have higher myelin water fraction in frontotemporal areas. This would suggest that, in cognitively healthy middle-aged individuals, the presence of amyloid in the brain, which represents a risk factor for AD, is accompanied by both cerebral microstructural decline in some areas and enhanced –possibly compensatory- microstructure properties in other areas.
GIGA - Cyclotron Research Center In Vivo Imaging
FNRS,ULiège,ARC17/21-09,FEDER,WBI,Clerdent Foundation
CoFitAge (Cognitive Fitness in Aging
Researchers ; Professionals ; Students ; General public
http://hdl.handle.net/2268/227994
10.3389/conf.fnins.2018.95.00056
https://www.frontiersin.org/10.3389/conf.fnins.2018.95.00056/event_abstract

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