Article (Scientific journals)
Approaches to target IgE antibodies in allergic diseases.
Balbino, Bianca; Conde, Eva; Marichal, Thomas et al.
2018In Pharmacology and Therapeutics
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Keywords :
Allergy; Anaphylaxis; Antibody; Asthma; Atopic dermatitis; CD23; DARPins; FcepsilonRI; FcepsilonRII; Immunoglobulin; Omalizumab
Abstract :
[en] IgE is the antibody isotype found at the lowest concentration in the circulation. However IgE can undeniably play an important role in mediating allergic reactions; best exemplified by the clinical benefits of anti-IgE monoclonal antibody (omalizumab) therapy for some allergic diseases. This review will describe our current understanding of the interactions between IgE and its main receptors FcepsilonRI and CD23 (FcepsilonRII). We will review the known and potential functions of IgE in health and disease: in particular, its detrimental roles in allergic diseases and chronic spontaneous urticaria, and its protective functions in host defense against parasites and venoms. Finally, we will present an overview of the drugs that are in clinical development or have therapeutic potential for IgE-mediated allergic diseases.
Disciplines :
Life sciences: Multidisciplinary, general & others
Author, co-author :
Balbino, Bianca
Conde, Eva
Marichal, Thomas  ;  Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire
Starkl, Philipp
Reber, Laurent L.
Language :
English
Title :
Approaches to target IgE antibodies in allergic diseases.
Publication date :
2018
Journal title :
Pharmacology and Therapeutics
ISSN :
0163-7258
eISSN :
1879-016X
Publisher :
Elsevier, United Kingdom
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Copyright (c) 2018 Elsevier Inc. All rights reserved.
Available on ORBi :
since 06 September 2018

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