Poster (Scientific congresses and symposiums)
Antimalarial and antitrypanosomal activity of strychnogucine B, a bisindole alkaloid from Strychnos icaja
Beaufay, Claire; Ledoux, Allison; Frederich, Michel et al.
20183eme symposium international AFERP STOLON
 

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Abstract :
[en] Strychnogucine B, a bisindole alkaloid isolated from Strychnos icaja (Loganiaceae), showed promising in vitro antiplasmodial properties (IC50 < 1μM) in previous studies [1, 2]. In order to obtain sufficient quantities to further investigate its antiprotozoal activity, this compound was synthesized in four steps from (-)-strychnine [3]. The in vivo antimalarial activity of this semi-synthetic strychnogucine B (30 mg/kg/d, i.p) was determined in a Plasmodium berghei murine model using the Peters’ 4-day suppressive test. This alkaloid confirmed a promising antimalarial activity in vivo by suppressing the parasitaemia by almost 36 percent on day 5 and 60 percent on day 7 compared to vehicle treated mice. In addition to this interesting antiplasmodial potential, it also showed a moderate in vitro anti-trypanosomal activity (IC50 = 2.7μM) but no in vivo activity in an acute Trypanosoma brucei model. It was also inactive in vitro on Leishmania mexicana promastigotes. This study highlights the selective antiplasmodial efficacy of strychnogucine B and warrants further investigations to assess the potential of this alkaloid as new antimalarial lead compound.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Beaufay, Claire;  Université Catholique de Louvain - UCL
Ledoux, Allison ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Frederich, Michel  ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Quetin-Leclercq, Joëlle ;  Université Catholique de Louvain - UCL
Zhao, S
Teijaro, CN
Andrade, RB
Jansen, Olivia ;  Université de Liège - ULiège > Département de pharmacie > Pharmacognosie
Language :
English
Title :
Antimalarial and antitrypanosomal activity of strychnogucine B, a bisindole alkaloid from Strychnos icaja
Publication date :
July 2018
Event name :
3eme symposium international AFERP STOLON
Event date :
18-20 juillet 2018
Audience :
International
Available on ORBi :
since 04 September 2018

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