Reference : Antimalarial and antitrypanosomal activity of strychnogucine B, a bisindole alkaloid ...
Scientific congresses and symposiums : Poster
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/227485
Antimalarial and antitrypanosomal activity of strychnogucine B, a bisindole alkaloid from Strychnos icaja
English
Beaufay, Claire [Université Catholique de Louvain - UCL > > > >]
Ledoux, Allison mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Frederich, Michel mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Quetin Leclercq, Joelle [Université Catholique de Louvain - UCL > > > >]
Zhao, S []
Teijaro, CN []
Andrade, RB []
Jansen, Olivia mailto [Université de Liège - ULiège > Département de pharmacie > Pharmacognosie >]
Jul-2018
Yes
International
3eme symposium international AFERP STOLON
18-20 juillet 2018
Rennes
[en] Strychnogucine B, a bisindole alkaloid isolated from Strychnos icaja (Loganiaceae), showed promising in vitro antiplasmodial properties (IC50 < 1μM) in previous studies [1, 2]. In order to obtain sufficient quantities to further investigate its antiprotozoal activity, this compound was synthesized in four steps from (-)-strychnine [3]. The in vivo antimalarial activity of this semi-synthetic strychnogucine B (30 mg/kg/d, i.p) was determined in a Plasmodium berghei murine model using the Peters’ 4-day suppressive test.
This alkaloid confirmed a promising antimalarial activity in vivo by suppressing the parasitaemia by almost 36 percent on day 5 and 60 percent on day 7 compared to vehicle treated mice.
In addition to this interesting antiplasmodial potential, it also showed a moderate in vitro anti-trypanosomal activity (IC50 = 2.7μM) but no in vivo activity in an acute Trypanosoma brucei model. It was also inactive in vitro on Leishmania mexicana promastigotes. This study highlights the selective antiplasmodial efficacy of strychnogucine B and warrants further investigations to assess the potential of this alkaloid as new antimalarial lead compound.
http://hdl.handle.net/2268/227485

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