Reference : Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in health...
Scientific journals : Article
Life sciences : Veterinary medicine & animal health
http://hdl.handle.net/2268/226913
Interbreed variation in serum serotonin (5-hydroxytryptamine) concentration in healthy dogs.
English
Höglund, Katja []
Häggström, Jens []
Hanas, S []
Merveille, Anne-Christine mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux >]
Gouni, Vassiliki []
Wiberg, Maria []
Lundgren Willesen, Jacob []
Mc Entee, Kathleen mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux >]
Mejer Sorensen, Louise []
Tiret, Laurent []
Seppälä, E []
Lohi, Hannes []
Chetboul, Valérie []
Fredholm, Merete []
Lequarré, Anne-Sophie mailto [Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux >]
Ljungvall, Ingrid []
Jun-2018
Journal of Veterinary Cardiology
Elsevier
Yes
International
1760-2734
1875-0834
Netherlands
[en] mitral valve disease ; canine ; breed variation
[en] INTRODUCTION:
Serotonin (5-hydroxytryptamine [5-HT]) has several biological functions. In different species, excessive 5-HT has been linked to valvular lesions, similar to those seen in dogs with myxomatous mitral valve disease. Previous studies suggest higher 5-HT in healthy Cavalier King Charles Spaniels (CKCSs), a breed highly affected by myxomatous mitral valve disease, compared to other breeds.

OBJECTIVE:
To investigate potential interbreed variation in serum 5-HT in healthy dogs.

ANIMALS:
483 healthy dogs of nine breeds aged 1-7 years.

METHODS:
Dogs were examined at five European centers. Absence of cardiovascular, organ-related, or systemic diseases was ensured by thorough clinical investigations including echocardiography. Serum was frozen and later analyzed by enzyme-linked immunosorbent assay (ELISA).

RESULTS:
Median 5-HT concentration was 252.5 (interquartile range = 145.5-390.6) ng/mL. Overall breed difference was found (p<0.0001), and 42% of pairwise breed comparisons were significant. Univariate regression analysis showed association between serum 5-HT concentration and breed, center of examination, storage time, and sex, with higher 5-HT in females. In multiple regression analysis, the final model had an adjusted R2 of 0.27 with breed (p<0.0001), center (p<0.0001), and storage time (p=0.014) remaining significant. Within centers, overall breed differences were found at 3/5 centers (p≤0.028), and pairwise comparisons within those centers showed breed differences in 42% of comparisons. Among the included breeds, Newfoundlands, Belgian Shepherds and CKCSs had highest 5-HT concentrations.

CONCLUSIONS:
Interbreed variation in serum 5-HT concentration was found in healthy dogs aged 1-7 years. These differences should be taken into account when designing clinical studies.
Researchers ; Professionals
http://hdl.handle.net/2268/226913
FP7 ; 201370 - LUPA - Unravelling the molecular basis of common complex human disorders using the dog as a model system

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