Breed differences in natriuretic peptides in healthy dogs

[en] BACKGROUND: Measurement of plasma concentration of natriuretic peptides (NPs) is suggested to be of value in diagnosis of cardiac disease in dogs, but many factors other than cardiac status may influence their concentrations. Dog breed potentially is 1 such factor. OBJECTIVE: To investigate breed variation in plasma concentrations of pro-atrial natriuretic peptide 31-67 (proANP 31-67) and N-terminal B-type natriuretic peptide (NT-proBNP) in healthy dogs. ANIMALS: 535 healthy, privately owned dogs of 9 breeds were examined at 5 centers as part of the European Union (EU) LUPA project. METHODS: Absence of cardiovascular disease or other clinically relevant organ-related or systemic disease was ensured by thorough clinical investigation. Plasma concentrations of proANP 31-67 and NT-proBNP were measured by commercially available ELISA assays. RESULTS: Overall significant breed differences were found in proANP 31-67 (P < .0001) and NT-proBNP (P < .0001) concentrations. Pair-wise comparisons between breeds differed in approximately 50% of comparisons for proANP 31-67 as well as NT-proBNP concentrations, both when including all centers and within each center. Interquartile range was large for many breeds, especially for NT-proBNP. Among included breeds, Labrador Retrievers and Newfoundlands had highest median NT-proBNP concentrations with concentrations 3 times as high as those of Dachshunds. German Shepherds and Cavalier King Charles Spaniels had the highest median proANP 31-67 concentrations, twice the median concentration in Doberman Pinschers. CONCLUSIONS AND CLINICAL IMPORTANCE: Considerable interbreed variation in plasma NP concentrations was found in healthy dogs. Intrabreed variation was large in several breeds, especially for NT-proBNP. Additional studies are needed to establish breed-specific reference ranges.

Disciplines :

Veterinary medicine & animal health

Author, co-author :

Sjöstrand, K

Wess, Gerard

Ljungvall, Ingrid

Häggström, Jens

Merveille, Anne-Christine ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux

Wiberg, Maria

Gouni, Vassiliki

Lundgren Willesen, Jacob

Hanas, S

Lequarré, Anne-Sophie ; Université de Liège - ULiège > Dép. clinique des animaux de compagnie et des équidés (DCA) > Pathologie médicale des petits animaux

More authors (14 more)

Language :

English

Title :

Breed differences in natriuretic peptides in healthy dogs

Publication date :

March 2014

Journal title :

Journal of Veterinary Internal Medicine

ISSN :

0891-6640

eISSN :

1939-1676

Publisher :

Wiley-Blackwell, United States

Volume :

Pages :

451

Peer reviewed :

Peer Reviewed verified by ORBi

European Projects :

FP7 - 201370 - LUPA - Unravelling the molecular basis of common complex human disorders using the dog as a model system

Funders :

CE - Commission Européenne [BE]

Available on ORBi :

since 06 August 2018

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