Article (Scientific journals)
Scale-up/Scale-down of microbial bioprocesses: a modern light on an old issue
Delvigne, Frank; Noorman, H.
2017In Microbial Biotechnology, 10 (4), p. 685-687
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Keywords :
Article; Escherichia coli
Abstract :
[en] The bio-economy is in transit from innovation to commercialization. The bioprocess industry is expected to increasingly deliver bio-products to the market, in large amounts, at high quality and at competitive cost levels. This requires flawless start-up of new large-scale bioprocesses and continuous improvement of running processes. Fermentation scale-up and operation can benefit from recent advances in three areas: 1. computation-driven design of scale-down simulators, 2. omics-driven metabolic engineering and 3. sensing and understanding of population heterogeneity. Integration of these fields requires a unified computational approach, linked to big data and simulated reality frameworks, of which the contours are becoming visible today. © 2017 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology.
Disciplines :
Biotechnology
Author, co-author :
Delvigne, Frank  ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Microbial, food and biobased technologies
Noorman, H.;  DSM Biotechnology Center, Delft, Netherlands, Department of Biotechnology, Technical University Delft, Delft, Netherlands
Language :
English
Title :
Scale-up/Scale-down of microbial bioprocesses: a modern light on an old issue
Publication date :
2017
Journal title :
Microbial Biotechnology
ISSN :
1751-7915
eISSN :
1751-7907
Publisher :
John Wiley and Sons Ltd
Volume :
10
Issue :
4
Pages :
685-687
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 July 2018

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