[en] The uncontrolled release in the extracellular medium of MPO, marker of inflammation, along with the release of ROS, causes severe damages on biological tissues. The modulation of the enzyme activity might constitute an approach for the treatment of excessive inflammation. According to several studies, morphine, which is already known for its analgesic properties, seems to present an antioxidant activity. Therefore, this reducing molecule can potentially pretend to be an inhibitor of MPO.
Disciplines :
Physics
Author, co-author :
Nyssen, Pauline ; Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Franck, Thierry ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Sauvage, Eric ; Université de Liège - ULiège > Département des sciences de la vie > Département des sciences de la vie
Mouithys-Mickalad, Ange ; Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Hoebeke, Maryse ; Université de Liège - ULiège > Département de physique > Spectroscopie biomédicale
Language :
English
Title :
Comparison of the action of morphine with potential inhibitors on the activity of MPO and HRP
