  | Decuyper, L., Magdalenić, K., Verstraete, M.-B., Jukič, M., Sosič, I., Sauvage, E., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (09 October 2019). α-Unsaturated 3-Amino-1-carboxymethyl-β-lactams as Bacterial PBP Inhibitors: Synthesis and Biochemical Assessment. Chemistry, 25 (70), 16128 - 16140. doi:10.1002/chem.201904139  Peer Reviewed verified by ORBi |
 | Vanden Broeck, A., Sauvage, E., Joris, B., & Duez, C. (05 March 2019). Characterization of the Bacillus subtilis Penicillin-Binding Protein PBP4*. Advances in Microbiology, 9 (3). doi:10.4236/aim.2019.93013 Peer reviewed |
 | Dondelinger, M., Filée, P., Sauvage, E., Quinting, B., Muyldermans, S., Galleni, M., & Vandevenne, M. (16 October 2018). Understanding the significance and implications of antibody numbering and antigen-binding surface/residue definition. Frontiers in Immunology, 9 (OCT). doi:10.3389/fimmu.2018.02278 Peer Reviewed verified by ORBi |
 | Decuyper, L., Deketelaere, S., Vanparys, L., Jukič, M., Sosič, I., Sauvage, E., Amoroso, A. M., Verlaine, O., Joris, B., Gobec, S., & D'hooghe, M. (12 October 2018). In Silico Design and Enantioselective Synthesis of Functionalized Monocyclic 3-Amino-1-carboxymethyl-β-lactams as Inhibitors of Penicillin-Binding Proteins of Resistant Bacteria. Chemistry, 24 (57), 15254-15266. doi:10.1002/chem.201801868 Peer Reviewed verified by ORBi |
 | Nyssen, P., Mouithys-Mickalad, A., MINGUET, G., Sauvage, E., Wouters, J., Franck, T., & Hoebeke, M. (October 2018). Morphine, a potential inhibitor of myeloperoxidase activity. Biochimica et Biophysica Acta - General Subjects, 1862 (10), 2236-2244. doi:10.1016/j.bbagen.2018.07.007 Peer Reviewed verified by ORBi |
 | Azarkan, M., Feller, G., Vandenameele, J., Herman, R., El Mahyaoui, R., Sauvage, E., Vanden Broeck, A., Matagne, A., Charlier, P., & Kerff, F. (2018). Biochemical and structural characterization of a mannose binding jacalin-related lectin with two-sugar binding sites from pineapple (Ananas comosus) stem. Scientific Reports. doi:10.1038/s41598-018-29439-x Peer Reviewed verified by ORBi |
 | Rodríguez, M. M., Herman, R., Ghiglione, B., Kerff, F., D'Amico González, G., Bouillenne, F., Galleni, M., Handelsman, J., Charlier, P., Gutkind, G., Sauvage, E., & Power, P. (July 2017). Crystal Structure and Kinetic Analysis of the Class B3 Di-Zinc Metallo-β-Lactamase LRA-12 from an Alaskan Soil Metagenome. PLoS ONE, 12 (7), 0182043. doi:10.1371/journal.pone.0182043 Peer Reviewed verified by ORBi |
 | Nyssen, P., Franck, T., Sauvage, E., Mouithys-Mickalad, A., & Hoebeke, M. (09 June 2017). Comparison of the action of morphine with potential inhibitors on the activity of MPO and HRP [Poster presentation]. Annual meeting CESAM Research Unit, Liège, Belgium. |
 | Léonard, R., Sirjacobs, D., Sauvage, E., Kerff, F., & Baurain, D. (11 May 2017). ToRQuEMaDA: Tool for retrieving queried eubacteria, metadata and dereplicating assemblie [Poster presentation]. PhD Student Day 2017, Liège, Belgium. |
  | El Ghachi, M., Howe, N., Auger, R., Lambion, A., Guiseppi, A., Delbrassine, F., Manat, G., Roure, S., Peslier, S., Sauvage, E., Vogeley, L., Rengifo-Gonzalez, J.-C., Charlier, P., Mengin-Lecreulx, D., Foglino, M., Touze, T., Caffrey, M., & Kerff, F. (2017). Crystal structure and biochemical characterization of the transmembrane PAP2 type phosphatidylglycerol phosphate phosphatase from Bacillus subtilis. Cellular and Molecular Life Sciences. doi:10.1007/s00018-017-2464-6 Peer Reviewed verified by ORBi |
 | Sauvage, E., & Terrak, M. (17 February 2016). Glycosyltransferases and Transpeptidases/Penicillin-Binding Proteins: Valuable Targets for New Antibacterials. Antibiotics, 5 (1). doi:10.3390/antibiotics5010012 Peer Reviewed verified by ORBi |
 | Stankovic, N., Schloesser, M., Joris, M., Sauvage, E., Hanikenne, M., & Motte, P. (February 2016). Dynamic Distribution and Interaction of the Arabidopsis SRSF1 Subfamily Splicing Factors. Plant Physiology, 170, 1000-1013. doi:10.1104/pp.15.01338 Peer Reviewed verified by ORBi |
 | Frère, J.-M., Sauvage, E., & Kerff, F. (2016). From "an enzyme able to destroy penicillin" to Carbapenemases: 70 Years of Beta-lactamase Misbehaviour. Current Drug Targets. doi:10.2174/1389450116666151001112859 Peer Reviewed verified by ORBi |
 | Léonard, R., Baurain, D., Kerff, F., Sauvage, E., & Sirjacobs, D. (07 December 2015). On the LZ distance for dereplicating redundant prokaryotic genomes [Poster presentation]. 10th Benelux Bioinformatics Conference, Antwerp, Belgium. |
 | Vanden Broeck, A., Van Der Heiden, E., Sauvage, E., Dauvin, M., Joris, B., & Duez, C. (2015). A lysine cluster in domain II of Bacillus subtilis PBP4a plays a role in the membrane attachment of this C1-PBP. PLoS ONE. doi:10.1371/journal.pone.0140082 Peer Reviewed verified by ORBi |
 | Vanden Broeck, A., Dauvin, M., Sauvage, E., & Duez, C. (08 June 2015). A lysine cluster in domain II of Bacillus subtilis PBP4a plays a role in the membrane attachment of this C1 PBP [Poster presentation]. IAP annual meeting iPRos project, Liège, Belgium. |
 | Ghiglione, B., Rodriguez, M. M., Herman, R., Curto, L., Dropa, M., Bouillenne, F., Kerff, F., Galleni, M., Charlier, P., Gutkind, G., Sauvage, E., & Power, P. (2015). Structural and Kinetic Insights into the "Ceftazidimase" Behavior of the Extended-Spectrum beta-Lactamase CTX-M-96. Biochemistry, 54 (32), 5072-82. doi:10.1021/acs.biochem.5b00313 Peer Reviewed verified by ORBi |
 | Kerff, F., El Ghachi, M., Herman, R., Sauvage, E., Frère, J.-M., & Charlier, P. (06 September 2014). Structures of the Carbapenemase OXA-24 in Complex with the β-lactamase Inhibitor Avibactam [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia. |
| Vanden Broeck, A., Van Der Heiden, E., Sauvage, E., Rhazi, N., Huynen, C., Verlaine, O., Joris, B., & Duez, C. (23 April 2014). Studies of the Domains II and III of Bacillus subtilis PBP4a in relation with the protein localization [Poster presentation]. IAP Day - iPROS, Ghent, Belgium. |
 | Sauvage, E., Derouaux, A., Fraipont, C., Joris, M., Herman, R., Rocaboy, M., Schloesser, M., Dumas, J., Kerff, F., Nguyen-Distèche, M., & Charlier, P. (2014). Crystal structure of penicillin-binding protein 3 (PBP3) from Escherichia coli. PLoS ONE. doi:10.1371/journal.pone.0098042 Peer Reviewed verified by ORBi |
 | Ruggiero, M., Kerff, F., Herman, R., Sapunaric, F., Galleni, M., Gutkind, G., Charlier, P., Sauvage, E., & Power, P. (2014). Crystal Structure of the Extended-Spectrum β -Lactamase PER-2 and Insights into the Role of Specific Residues in the Interaction with β -Lactams and β -Lactamase Inhibitors. Antimicrobial Agents and Chemotherapy, 58 (10), 5994-6002. doi:10.1128/AAC.00089-14 Peer Reviewed verified by ORBi |
 | Power, P., Sauvage, E., Herman, R., Gutkin, G., Galleni, M., Charlier, P., & Kerff, F. (2014). The crystal structure of the carbapenemase OXA-24 in complex with tazobactam reveals evidences about the intereaction with beta-lactamase inhibitors and lysine carboxylation [Poster presentation]. 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, United States - District of Columbia. |
 | Dzhekieva, L., Adediran, S. A., Herman, R., Kerff, F., Duez, C., Charlier, P., Sauvage, E., & Pratt, R. F. (2013). Inhibition of dd-Peptidases by a Specific Trifluoroketone: Crystal Structure of a Complex with the Actinomadura R39 dd-Peptidase. Biochemistry. doi:10.1021/bi400048s Peer Reviewed verified by ORBi |
 | Sauvage, E., & Frère, J.-M. (2013). Actinomadura R39 d-Ala-d-Ala Carboxypeptidase. In Handbook of Proteolytic Enzymes (pp. 3480-3484). Elsevier. doi:10.1016/B978-0-12-382219-2.00771-7 Peer reviewed |
 | Derouaux, A., Sauvage, E., & Terrak, M. (2013). Peptidoglycan glycosyltransferase substrate mimics as templates for the design of new antibacterial drugs. Frontiers in Immunology, 4, 78. doi:10.3389/fimmu.2013.00078 Peer Reviewed verified by ORBi |
 | Rocaboy, M., Herman, R., Sauvage, E., Remaut, H., Moonens, K., Terrak, M., Charlier, P., & Kerff, F. (2013). The crystal structure of the cell division amidase AmiC reveals the fold of the AMIN domain, a new peptidoglycan binding domain. Molecular Microbiology. doi:10.1111/mmi.12361 Peer Reviewed verified by ORBi |
 | Dive, G., Bouillon, C., Sliwa, A., Valet, B., Verlaine, O., Sauvage, E., & Marchand-Brynaert, J. (2013). Macrocyle-embedded b-lactams as novel inhibitors of the Penicillin Binding Protein PBP2a from MRSA. European Journal of Medicinal Chemistry, 64, 365-376. doi:10.1016/j.ejmech.2013.03.052 Peer Reviewed verified by ORBi |
 | Brulé, C., Grugier, J., Brans, A., Joris, B., Sauvage, E., Dive, G., & Marchand-Brynaert, J. (2013). 2-nitrobenzyl esters of penam and cephem derivatives as inhibitors of penicillin-binding proteins. Asian Journal of Organic Chemistry, 2, 654-661. doi:10.1002/ajoc.201300108 Peer Reviewed verified by ORBi |
| Kerff, F., Rocaboy, M., Herman, R., Sauvage, E., Moonens, K., Remaut, H., Charlier, P., & Terrak, M. (25 June 2012). Structure of the E. coli amidase AmiC and its activation by the LytM cofactor NlpD [Poster presentation]. Gordon Research Conference on bacterial Cell Surfaces, West Dover, VT, United States. |
Zervosen, A., Sauvage, E., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Charlier, P., & Luxen, A. (18 April 2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C [Poster presentation]. Biomedica 2012, Liège, Belgium. |
 | Zervosen, A., Sauvage, E., Frère, J.-M., Charlier, P., & Luxen, A. (2012). Development of new drugs for an old target — the penicillin binding proteins. Molecules, 17 (11), 12478-505. doi:10.3390/molecules171112478 Peer Reviewed verified by ORBi |
 | Power, P., Mercuri, P., Herman, R., Kerff, F., Gutkind, G., Dive, G., Galleni, M., Charlier, P., & Sauvage, E. (2012). Novel fragments of clavulanate observed in the structure of the class A b-lactamase from Bacillus licheniformis BS3. Journal of Antimicrobial Chemotherapy, 67 (10), 2379-2387. doi:10.1093/jac/dks231 Peer Reviewed verified by ORBi |
| Zervosen, A., Bouillez, A., Herman, A., Amoroso, A. M., Joris, B., Sauvage, E., Charlier, P., & Luxen, A. (2012). Synthesis and evaluation of boronic acids as inhibitors of Penicillin Binding Proteins of classes A, B and C. Bioorganic and Medicinal Chemistry, 20 (12), 3915-24. doi:10.1016/j.bmc.2012.04.018 Peer Reviewed verified by ORBi |
 | Sliwa, A., Dive, G., Zervosen, A., Verlaine, O., Sauvage, E., & Marchand-Brynaert, J. (2012). Unprecedented inhibition of resistant penicillin binding proteins by bis-2-oxoazetidinyl macrocycles. MedChemComm, 3, 344-351. doi:10.1039/c2md00251e Peer Reviewed verified by ORBi |
 | Zervosen, A., Herman, R., Kerff, F., Herman, A., Bouillez, A., Prati, F., Pratt, R. F., Frère, J.-M., Joris, B., Luxen, A., Charlier, P., & Sauvage, E. (2011). Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin binding protein. Journal of the American Chemical Society. doi:10.1021/ja200696y Peer Reviewed verified by ORBi |
 | Adediran, S. A., Kumar, I., Nagarajan, Sauvage, E., & Pratt, R. F. (2011). Kinetics of Reactions of the Actinomadura R39 dd-Peptidase with Specific Substrates. Biochemistry, 50 (3), 376-387. doi:10.1021/bi101760p Peer Reviewed verified by ORBi |
 | Woon, E. C. Y., Zervosen, A., Sauvage, E., Simmons, K. J., Zivec, M., Inglis, S. R., Fishwick, C. W. G., Gobec, S., Charlier, P., Luxen, A., & Schofield, C. J. (2011). Structure Guided Development of Potent Reversibly Binding Penicillin Binding Protein Inhibitors. ACS Medicinal Chemistry Letters, 2 (3), 219-223. doi:10.1021/ml100260x Peer Reviewed verified by ORBi |
 | Kerff, F., Sauvage, E., Vercheval, L., & Charlier, P. (2011). Structures of class D β-lactamases. In J.-M. Frère (Ed.), Beta-lactamases. Nova Science Publishers. |
| Vercheval, L., Di Paolo, A., Borel, F., Ferrer, J.-L., Sauvage, E., Matagne, A., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (25 November 2010). Three factors that modulate the activity of class D β-lactamases and interfere with the post-translational carboxylation of Lys 70. Biochemical Journal, 432 (3), 495-504. doi:10.1042/BJ20101122 Peer Reviewed verified by ORBi |
| Bebrone, C., Lassaux, P., Vercheval, L., Sohier, J., Jehaes, A., Sauvage, E., & Galleni, M. (16 April 2010). Current challenges in antimicrobial chemotherapy: focus on beta-lactamase inhibition. Drugs, 70(6), 651-679. doi:10.2165/11318430-000000000-00000 Peer Reviewed verified by ORBi |
 | Brown, T. J., Charlier, P., Herman, R., Schofield, C. J., & Sauvage, E. (2010). Structural basis for the interaction of lactivicins with serine beta-lactamases. Journal of Medicinal Chemistry, 53 (15), 5890-4. doi:10.1021/jm100437u Peer Reviewed verified by ORBi |
 | Dzhekieva, L., Rocaboy, M., Kerff, F., Charlier, P., Sauvage, E., & Pratt, R. F. (2010). Crystal structure of a complex between the Actinomadura R39 DD-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism. Biochemistry, 49 (30), 6411-9. doi:10.1021/bi100757c Peer Reviewed verified by ORBi |
 | Kerff, F., Petrella, S., Mercier, F., Sauvage, E., Herman, R., Pennartz, A., Zervosen, A., Luxen, A., Frère, J.-M., Joris, B., & Charlier, P. (2010). Specific Structural Features of the N-Acetylmuramoyl-l-Alanine Amidase AmiD from Escherichia coli and Mechanistic Implications for Enzymes of This Family. Journal of Molecular Biology, 397, 249-259. doi:10.1016/j.jmb.2009.12.038 Peer Reviewed verified by ORBi |
 | Baurin, S., Vercheval, L., Bouillenne, F., Falzone, C., Brans, A., Jacquamet, L., Ferrer, J.-L., Sauvage, E., Dehareng, D., Frère, J.-M., Charlier, P., Galleni, M., & Kerff, F. (2009). Critical role of tryptophan 154 for the activity and stability of class D beta-lactamases. Biochemistry, 48 (47), 11252-63. doi:10.1021/bi901548c Peer Reviewed verified by ORBi |
 | Sauvage, E., Zervosen, A., Dive, G., Herman, R., Amoroso, A. M., Joris, B., Fonzé, E., Pratt, R., Luxen, A., Charlier, P., & Kerff, F. (2009). Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate. Journal of the American Chemical Society, 131 (42), 15262-15269. doi:10.1021/ja9051526 Peer Reviewed verified by ORBi |
 | Sauvage, E.* , Kerff, F.* , Terrak, M., Ayala, J. A., & Charlier, P. (March 2008). The Penicillin-Binding Proteins: Structure and Role in Peptidoglycan Biosynthesis. FEMS Microbiology Reviews, 32 (2), 234-58. doi:10.1111/j.1574-6976.2008.00105.x Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Sauvage, E., Powell, A. J., Heilemann, J., Josephine, H. R., Charlier, P., Davies, C., & Pratt, R. F. (2008). Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle. Journal of Molecular Biology, 381 (2), 383-93. doi:10.1016/j.jmb.2008.06.012 Peer Reviewed verified by ORBi |
 | Kerff, F., Amoroso, A. M., Herman, R., Sauvage, E., Petrella, S., Filée, P., Charlier, P., Joris, B., Tabuchi, A., Nikolaidis, N., & Cosgrove, D. J. (2008). Crystal structure and activity of Bacillus subtilis YoaJ (EXLX1), a bacterial expansin that promotes root colonization. Proceedings of the National Academy of Sciences of the United States of America, 105 (44), 16876-81. doi:10.1073/pnas.0809382105 Peer Reviewed verified by ORBi |
 | Beck, J., Sauvage, E., Charlier, P., & Marchand-Brynaert, J. (2008). 2-Aminopropane-1,2,3-tricarboxylic acid: Synthesis and co-crystallization with the class A beta-lactamase BS3 of Bacillus licheniformis. Bioorganic and Medicinal Chemistry Letters, 18 (13), 3764-8. doi:10.1016/j.bmcl.2008.05.045 Peer Reviewed verified by ORBi |
 | Terrak, M., Sauvage, E., Derouaux, A., Dehareng, D., Bouhss, A., Breukink, E., Jeanjean, S., & Nguyen-Distèche, M. (2008). Importance of the conserved residues in the peptidoglycan glycosyltransferase module of the class A penicillin-binding protein 1b of Escherichia coli. Journal of Biological Chemistry, 283 (42), 28464-70. doi:10.1074/jbc.M803223200 Peer Reviewed verified by ORBi |
 | Sauvage, E., Duez, C., Herman, R., Kerff, F., Petrella, S., Anderson, J. W., Adediran, S. A., Pratt, R. F., Frère, J.-M., & Charlier, P. (10 August 2007). Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide. Journal of Molecular Biology, 371 (2), 528-539. doi:10.1016/j.jmb.2007.05.071 Peer Reviewed verified by ORBi |
 | Leimanis, S., Hoyez, N., Hubert, S., Laschet, M., Sauvage, E., Brasseur, R., & Coyette, J. (September 2006). PBP5 complementation of a PBP3 deficiency in Enterococcus hirae. Journal of Bacteriology, 188 (17), 6298-6307. doi:10.1128/JB.00334-06 Peer Reviewed verified by ORBi |
 | Sauvage, E., Fonze, E., Quinting, B., Galleni, M., Frère, J.-M., & Charlier, P. (2006). Crystal structure of the Mycobacterium fortuitum class A beta-lactamase: structural basis for broad substrate specificity. Antimicrobial Agents and Chemotherapy, 50 (7), 2516-21. doi:10.1128/AAC.01226-05 Peer Reviewed verified by ORBi |
 | Rhazi, N., Delmarcelle, M., Sauvage, E., Jacquemotte, F., Devriendt, K., Tallon, V., Ghosez, L., & Frère, J.-M. (November 2005). Specificity and reversibility of the transpeptidation reaction catalyzed by the Streptomyces R61 D-Ala-D-Ala peptidase. Protein Science: A Publication of the Protein Society, 14 (11), 2922-2928. doi:10.1110/ps.051641005 Peer Reviewed verified by ORBi |
 | Sauvage, E., Herman, R., Petrella, S., Duez, C., Bouillenne, F., Frère, J.-M., & Charlier, P. (2005). Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins. Journal of Biological Chemistry, 280 (35), 31249-56. doi:10.1074/jbc.M503271200 Peer Reviewed verified by ORBi |
 | Kerff, F., Charlier, P., Colombo, M. L., Sauvage, E., Brans, A., Frère, J.-M., Joris, B., & Fonze, E. (11 November 2003). Crystal structure of the sensor domain of the BlaR penicillin receptor from Bacillus licheniformis. Biochemistry, 42 (44), 12835-12843. doi:10.1021/bi034976a Peer Reviewed verified by ORBi |
 | Fonzé, E., Vanhove, M., Dive, G., Sauvage, E., Frère, J.-M., & Charlier, P. (February 2002). Crystal structures of the Bacillus licheniformis BS3 class A beta-lactamase and of the acyl-enzyme adduct formed with cefoxitin. Biochemistry, 41 (6), 1877-1885. doi:10.1021/bi015789k Peer Reviewed verified by ORBi |
 | Sauvage, E., Kerff, F., Fonze, E., Herman, R., Schoot, B., Marquette, J. P., Taburet, Y., Prevost, D., Dumas, J., Stefanic, P., Coyette, J., Charlier, P., & Leonard, G. (2002). The 2.4-A crystal structure of the penicillin-resistant penicillin-binding protein PBP5fm from Enterococcus faecium in complex with benzylpenicillin. Cellular and Molecular Life Sciences, 59 (7), 1223-32. doi:10.1007/s00018-002-8500-0 Peer Reviewed verified by ORBi |