Reference : Towards a spray-coating method for the detection of low-dose compounds in pharmaceuti...
Scientific journals : Article
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/225319
Towards a spray-coating method for the detection of low-dose compounds in pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI)
English
Cailletaud, Johan mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
De Bleye, Charlotte mailto [Université de Liège - ULiège > Département de pharmacie > Département de pharmacie >]
Dumont, Elodie mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Sacre, Pierre-Yves mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Gut, Yoann mailto [Technologie Servier > > > >]
Bultel, Laurent mailto [Technologie Servier > > > >]
Ginot, Yves-Michel mailto [> >]
Hubert, Philippe mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège - ULiège > Département de pharmacie > Département de pharmacie >]
1-Oct-2018
Talanta
Elsevier
188
584-592
Yes (verified by ORBi)
International
0039-9140
1873-3573
Netherlands
[en] Surface-enhanced Raman scattering (SERS) ; Spray-coating ; Metallic colloidal suspension ; Silver nanoparticles ; Chemical imaging ; Pharmaceutical tablets
[en] Surface-enhanced Raman chemical imaging (SER-CI) is a highly sensitive analytical tool recently used in the
pharmaceutical field owing to the possibility to obtain high sensitivity along with spatial information. However,
the covering method of the pharmaceutical samples such as tablets with metallic nanoparticles is a major issue
for SER-CI analyses due to the difficulty to obtain a homogeneous covering of tablet surface with the SERS
substrates. In this context, a spray-coating method was proposed in order to fully exploit the potential of SER-CI.
A homemade apparatus has been developed from an electrospray ionization (ESI) probe in order to cover the
pharmaceutical tablets with the colloidal suspension in a homogeneous way. The silver substrate was pulled
through the airbrush by a syringe pump which was then nebulized into small droplets due to the contact of the
solution with the gas flow turbulence. A robust optimization of the process was carried out by adjusting experimental
parameters such as the liquid flow rate and the spraying time. Besides, the performances of this
spraying technique were compared with two others covering methods found in the literature which are drop
casting and absorption coating. A homogeneity study, conducted by SER-CI and matrix assisted laser desorption/
ionization mass spectrometry imaging (MALDI-MSI) applied to the different covering techniques was performed.
The influence of the metallic nanoparticles deposit on soluble compounds was also investigated in order to
highlight the advantages of using this new spray coating approach.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Researchers ; Professionals ; Students
http://hdl.handle.net/2268/225319
10.1016/j.talanta.2018.06.037

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