Towards a spray-coating method for the detection of low-dose compounds in pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI)
Cailletaud, Johan; De Bleye, Charlotte; Dumont, Elodieet al.
Cailletaud (2018) - Towards a spray-coating method for the detection of low-dose compounds in compounds in pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI).pdf
[en] Surface-enhanced Raman chemical imaging (SER-CI) is a highly sensitive analytical tool recently used in the
pharmaceutical field owing to the possibility to obtain high sensitivity along with spatial information. However,
the covering method of the pharmaceutical samples such as tablets with metallic nanoparticles is a major issue
for SER-CI analyses due to the difficulty to obtain a homogeneous covering of tablet surface with the SERS
substrates. In this context, a spray-coating method was proposed in order to fully exploit the potential of SER-CI.
A homemade apparatus has been developed from an electrospray ionization (ESI) probe in order to cover the
pharmaceutical tablets with the colloidal suspension in a homogeneous way. The silver substrate was pulled
through the airbrush by a syringe pump which was then nebulized into small droplets due to the contact of the
solution with the gas flow turbulence. A robust optimization of the process was carried out by adjusting experimental
parameters such as the liquid flow rate and the spraying time. Besides, the performances of this
spraying technique were compared with two others covering methods found in the literature which are drop
casting and absorption coating. A homogeneity study, conducted by SER-CI and matrix assisted laser desorption/
ionization mass spectrometry imaging (MALDI-MSI) applied to the different covering techniques was performed.
The influence of the metallic nanoparticles deposit on soluble compounds was also investigated in order to
highlight the advantages of using this new spray coating approach.
Research center :
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Cailletaud, Johan ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
De Bleye, Charlotte ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Dumont, Elodie ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Sacre, Pierre-Yves ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Gut, Yoann; Technologie Servier
Bultel, Laurent; Technologie Servier
Ginot, Yves-Michel
Hubert, Philippe ; Université de Liège - ULiège > Département de pharmacie > Chimie analytique
Ziemons, Eric ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Towards a spray-coating method for the detection of low-dose compounds in pharmaceutical tablets using surface-enhanced Raman chemical imaging (SER-CI)
Firkala, T., Farkas, A., Vajna, B., Farkas, I., Marosi, G., Investigation of drug distribution in tablets using surface enhanced Raman chemical imaging. J. Pharm. Biomed. Anal. 76 (2013), 145–151.
Firkala, T., Farkas, A., Vajna, B., Nagy, Z.K., Pokol, G., Marosi, G., Szilagyi, I.M., Quantification of low drug concentration in model formulations with multivariate analysis using surface enhanced Raman chemical imaging. J. Pharm. Biomed. Anal. 107 (2015), 318–324.
Cailletaud, J., De Bleye, C., Dumont, E., Sacré, P.-Y., Netchacovitch, L., Gut, Y., Boiret, M., Ginot, Y.-M., Hubert, P., Ziemons, E., Critical review of surface-enhanced Raman spectroscopy applications in the pharmaceutical field. J. Pharm. Biomed. Anal. 147 (2017), 458–472.
Bell, S.E.J., Fido, L.A., Sirimuthu, N.M.S., Speers, S.J., Peters, K.L., Cosbey, S.H., Screening tablets for DOB using surface-enhanced Raman spectroscopy. J. Forensic Sci. 52 (2007), 1063–1067.
De Bleye, C., Sacré, P.Y., Dumont, E., Netchacovitch, L., Chavez, P.F., Piel, G., Lebrun, P., Hubert, P., Ziemons, E., Development of a quantitative approach using surface-enhanced Raman chemical imaging: first step for the determination of an impurity in a pharmaceutical model. J. Pharm. Biomed. Anal. 90 (2014), 111–118.
Deegan, R.D., Bakajin, O., Dupont, T.F., Huber, G., Nagel, S.R., Witten, T.A., Capillary flow as the cause of ring stains from dried liquid drops. Nature 389 (1997), 827–829.
Ely, F., Matsumoto, A., Zoetebier, B., Peressinotto, V.S., Hirata, M.K., de Sousa, D.A., Maciel, R., Handheld and automated ultrasonic spray deposition of conductive PEDOT:PSS films and their application in AC EL devices. Org. Electron. 15 (2014), 1062–1070.
Majumder, M., Rendall, C., Li, M., Behabtu, N., Eukel, J.A., Hauge, R.H., Schmidt, H.K., Pasquali, M., Insights into the physics of spray coating of SWNT films. Chem. Eng. Sci. 65 (2010), 2000–2008.
Abdellah, A., Fabel, B., Lugli, P., Scarpa, G., Spray deposition of organic semiconducting thin-films: towards the fabrication of arbitrary shaped organic electronic devices. Org. Electron. 11 (2010), 1031–1038.
Bastwros, M., Kim, G.Y., Ultrasonic spray deposition of SiC nanoparticles for laminate metal composite fabrication. Powder Technol. 288 (2016), 279–285.
Brayner, R., Iglesias, R., Truong, S., Beji, Z., Felidj, N., Fiévet, F., Aubard, J., Surface-enhanced Raman scattering on silver nanostructured films prepared by spray-deposition. Langmuir 26 (2010), 17465–17469.
Li, B., Zhang, W., Chen, L., Lin, B., A fast and low-cost spray method for prototyping and depositing surface-enhanced Raman scattering arrays on microfluidic paper based device. Electrophoresis 34 (2013), 2162–2168.
Bolz, A., Panne, U., Rurack, K., Buurman, M., Glass fibre paper-based test strips for sensitive SERS sensing. Anal. Methods 8 (2016), 1313–1318.
Sarycheva, A., Makaryan, T., Maleski, K., Satheeshkumar, E., Melikyan, A., Minassian, H., Yoshimura, M., Gogotsi, Y., Two-dimensional titanium carbide (MXene) as surface-enhanced Raman scattering substrate. J. Phys. Chem. C 121 (2017), 19983–19988.
Lee, P.C., Meisel, D., Adsorption and surface-enhanced Raman of dyes on silver and gold sols. J. Phys. Chem. 86 (1982), 3391–3395.
De Bleye, C., Dumont, E., Rozet, E., Sacré, P.-Y., Chavez, P.-F., Netchacovitch, L., Piel, G., Hubert, P., Ziemons, E., Determination of 4-aminophenol in a pharmaceutical formulation using surface enhanced Raman scattering: from development to method validation. Talanta 116 (2013), 899–905.
Hankin, J.A., Barkley, R.M., Murphy, R.C., Sublimation as a method of matrix application for mass spectrometric imaging. J. Am. Soc. Mass Spectrom. 18 (2007), 1646–1652.
Thomas, A., Charbonneau, J.L., Fournaise, E., Chaurand, P., Sublimation of new matrix candidates for high spatial resolution imaging mass spectrometry of lipids: enhanced information in both positive and negative polarities after 1,5-diaminonapthalene deposition. Anal. Chem. 84 (2012), 2048–2054.
Eilers, P.H.C., Parametric time warping. Anal. Chem. 76 (2004), 404–411.
J. MacQueen, Some methods for classification and analysis of multivariate observations, in: Proceedings of the Fifth Berkeley Symposium on Mathematical Statistics and Probability, Volume 1: Statistics, University of California Press, Berkeley, Calif, 1967, pp. 281–297.
Gut, Y., Boiret, M., Bultel, L., Renaud, T., Chetouani, A., Hafiane, A., Ginot, Y.-M., Jennane, R., Application of chemometric algorithms to MALDI mass spectrometry imaging of pharmaceutical tablets. J. Pharm. Biomed. Anal. 105 (2015), 91–100.
Leopold, N., Lendl, B., A new method for fast preparation of highly surface-enhanced Raman scattering (SERS) active silver colloids at room temperature by reduction of silver nitrate with hydroxylamine hydrochloride. J. Phys. Chem. B 107 (2003), 5723–5727.
Alvarez-Puebla, R.A., Arceo, E., Goulet, P.J.G., Garrido, J.J., Aroca, R.F., Role of nanoparticle surface charge in surface-enhanced Raman scattering. J. Phys. Chem. B 109 (2005), 3787–3792.
Holcomb, A., Owens, K.G., Optimization of a modified aerospray deposition device for the preparation of samples for quantitative analysis by MALDI-TOFMS. Anal. Chim. Acta 658 (2010), 49–55.
Girotto, C., Rand, B.P., Genoe, J., Heremans, P., Exploring spray coating as a deposition technique for the fabrication of solution-processed solar cells. Sol. Energy Mater. Sol. Cells 93 (2009), 454–458.
Concina, I., Memarian, N., Selopal, G.S., Natile, M.M., Sberveglieri, G., Vomiero, A., Spray-assisted silar deposition of cadmium sulphide quantum dots on metal oxide films for excitonic solar cells. J. Power Sources 240 (2013), 736–744.
Lauzon, N., Dufresne, M., Chauhan, V., Chaurand, P., Development of laser desorption imaging mass spectrometry methods to investigate the molecular composition of latent fingermarks. J. Am. Soc. Mass Spectrom. 26 (2015), 878–886.
Lauzon, N., Dufresne, M., Beaudoin, A., Chaurand, P., Forensic analysis of latent fingermarks by silver-assisted LDI imaging MS on nonconductive surfaces. J. Mass Spectrom. 52 (2017), 397–404.
