Sulphated polysaccharide isolated from Sargassum vulgare: Characterization and hypolipidemic effects

Dyslipidemia; GCMS analysis; NMR spectroscopy; Sargassum vulgare; Sulphated polysaccharide; Algae; Chromatography; Differential scanning calorimetry; Lipids; Mass spectrometry; Nuclear magnetic resonance spectroscopy; Spectroscopic analysis; Toxicity; X ray diffraction analysis; Dyslipidemias; Gas chromatography-mass spectrometry; GC-MS analysis; Homogeneous structure; Semi-crystalline polymer; Structural characterization; Sulphated polysaccharides; Gas chromatography

Résumé :

[en] A sulphated polysaccharide from brown algae Sargassum vulgare (SVSP) was extracted and examined with respect to chemical, structural characterization and hypolipidemic effects. SVSP consisted mainly of sulphate and total sugars with low levels of lipids and proteins. Its structure was studied by nuclear magnetic resonance (RMN), gas chromatography-mass spectrometry (GC–MS), infra-red spectroscopic, differential scanning calorimetry and X-ray diffraction analysis. Allowing us therefore to revealed that SVSP was composed of glucose, rhamnose, xylose, galactose, mannose and arabinose with XRD pattern that was typical for a semi-crystalline polymer and complexities of the spectra reflected its homogeneous structure. The administration of SVSP to obese rats is effective in lowering the body weight and inhibiting the lipase activity leading to notable regulation of lipid profile, increasing the activities of antioxidant enzymes, limiting lipid peroxidation; and protects liver-kidney functions proved by a decrease in the levels of toxicity parameters in blood, confirmed by histological study. © 2017

Disciplines :

Sciences des denrées alimentaires

Auteur, co-auteur :

Kolsi, R. B. A.; Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, Sfax, Tunisia

Salah, H. B.; Laboratory of chemistry of Natural Substances, Faculty of Sciences of Sfax, PB 802, Sfax, Tunisia

Jardak, N.; Research Unit of anatomy, histology and embryology, Faculty of Medicine Sfax, Tunisia

Chaaben, R.; Biochemistry Laboratory, CHU Hedi Chaker, Sfax, Tunisia

Jribi, I.; Biodiversity Unit and Aquatic Ecosystems, Faculty of Sciences of Sfax, Sfax, Tunisia

Feki, A. E.; Laboratory of Animal Ecophysiology, Faculty of Sciences of Sfax, Tunisia

Rebai, T.; Research Unit of anatomy, histology and embryology, Faculty of Medicine Sfax, Tunisia

Jamoussi, K.; Biochemistry Laboratory, CHU Hedi Chaker, Sfax, Tunisia

Allouche, N.; Laboratory of chemistry of Natural Substances, Faculty of Sciences of Sfax, PB 802, Sfax, Tunisia

Blecker, Christophe ; Université de Liège - ULiège > SMARTECH

Belghith, H.; Enzyme and Bioconversion Unit, Biotechnology Center of Sfax, Tunisia

Belghith, K.; Laboratory of Plant Biotechnology, Faculty of Sciences of Sfax, Sfax, Tunisia

Langue du document :

Anglais

Titre :

Sulphated polysaccharide isolated from Sargassum vulgare: Characterization and hypolipidemic effects

Date de publication/diffusion :

2017

Titre du périodique :

Carbohydrate Polymers

ISSN :

0144-8617

eISSN :

1879-1344

Maison d'édition :

Elsevier

Volume/Tome :

170

Pagination :

148-159

Peer reviewed :

Peer reviewed vérifié par ORBi

Disponible sur ORBi :

depuis le 12 juin 2018

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125 (dont 1 ULiège)

Nombre de téléchargements

1 (dont 0 ULiège)

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