Reference : Transfer of active pharmaceutical ingredients (API) Raman library from bench top towa...
Scientific congresses and symposiums : Unpublished conference/Abstract
Human health sciences : Pharmacy, pharmacology & toxicology
Transfer of active pharmaceutical ingredients (API) Raman library from bench top towards handheld spectrometers
Clavaud, Matthieu mailto [Université de Liège - ULiège > > > Form. doct. sc. biomed. & pharma. (paysage)]
Sacre, Pierre-Yves mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Hubert, Philippe mailto [Université de Liège - ULiège > Département de pharmacie > Chimie analytique >]
Ziemons, Eric mailto [Université de Liège - ULiège > Département de pharmacie > Département de pharmacie >]
International Syposium DA-PBA 2018
9-12 september 2018
KU Leuven
[en] Raman spectroscopy ; Handheld spectrometer ; Transfer ; Active Pharmaceutical Ingredients
[en] Over the last few years, manufacturers have made progress miniaturizing Raman spectrometers and trying to meet the practical needs of the end-users for raw material and finished goods identification.
In this study, library transfer from a donor benchtop Raman towards different Raman receiver devices, benchtop and handheld, was evaluated. The aim was to create a library of active pharmaceutical ingredients (API) on a lab spectrometer and to show that a transfer to different Raman systems using the Hit Quality Index (HQI) algorithm is possible. Consequently, library creation would be faster as well as the set-up of a device for routine measurements avoiding the acquisition of hundreds sample on each system, and allow optimizing method update strategy.
A donor benchtop DXR SmartRaman (Thermo Fisher Scientific®) and receivers composed of a benchtop RXN1 (Kaiser Optical System®), and two handheld spectrometers respectively Truscan (Thermo Fisher Scientific®) and MIRA M-1 (Metrohm AG®) were selected. All spectrometers were equipped with a 785 nm near infrared excitation laser to avoid variation in laser differences.
The Orbital-Raster-Scanning (ORS) technology available on the MIRA M-1 was initially evaluated. Understanding the effect of the ORS technique on APIs was a previous step before setting up a database transfer experiment. Subsequently, acetaminophen was used for library standardization to calibrate the x-axis of the Raman spectrometers. Finally, Raman spectra were pre-processed prior to computation of the HQI method.
The results showed that transferring an API library from a benchtop Raman system towards handheld systems with HQI values higher than 90% is possible. Additionally, an HQI of maximum 75% was observed between the different APIs suggesting that the APIs were different enough allowing a transfer.
Centre Interdisciplinaire de Recherche sur le Médicament - CIRM
Researchers ; Professionals

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