The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

[en] Lung macrophages have mostly been studied considering only their most accessible and well-de fined representative, the alveolar macrophage (AM). In contrast, the identity and putative immune functions of their tissue counterpart, the interstitial macrophage (IM), have long remained much more elusive. Yet, recent evidence supports the notion that IMs perform important immune functions in the lung, notably in terms of innate immunoregulation. Here, we review current knowledge on the phenotype, ontogeny and function of IMs and propose strategies for the unambiguous identification and study of this important and dynamic lung innate immune cell population

Disciplines :

Biochemistry, biophysics & molecular biology
Veterinary medicine & animal health

Author, co-author :

Liégeois, Maude ^✱; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Legrand, Céline ^✱; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Desmet, Christophe ^✱; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Marichal, Thomas ^✱; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Bureau, Fabrice ^✱; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

^✱ These authors have contributed equally to this work.

Language :

English

Title :

The interstitial macrophage: A long-neglected piece in the puzzle of lung immunity

Publication date :

2018

Journal title :

Cellular Immunology

ISSN :

0008-8749

eISSN :

1090-2163

Publisher :

Elsevier, Atlanta, United States - Florida

Volume :

330

Pages :

91-96

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

WELBIO - Institut wallon virtuel de recherche d'excellence dans les domaines des sciences de la vie [BE]
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE]
Fondation Acteria (Agir sur la Recherche européenne en Immunologie et en Allergologie) [CH]

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since 18 April 2018

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