Article (Scientific journals)
Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies
Pinson, Anneline; Franssen, Delphine; Gerard, Amaury et al.
2017In Comptes Rendus Biologies, 340 (9-10), p. 432-438
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Keywords :
Behaviour; Central nervous system; Endocrine disruptors; Mode of action; Neurodevelopment; Reproduction; PCB; Short Survey
Abstract :
[en] Endocrine disruption is commonly thought to be restricted to a direct endocrine mode of action i.e. the perturbation of the activation of a given type of hormonal receptor by its natural ligand. Consistent with the WHO definition of an endocrine disrupter, a key issue is the “altered function(s) of the endocrine system”. Such altered functions can result from different chemical interactions, beyond agonistic or antagonistic effect at a given receptor. Based on neuroendocrine disruption by polychlorinated biphenyls and bisphenol A, this paper proposes different mechanistic paradigms that can result in adverse health effects. They are a consequence of altered endocrine function(s) secondary to chemical interaction with different steps in the physiological regulatory processes, thus accounting for a possibly indirect endocrine mode of action. © 2017 Académie des sciences
Disciplines :
Endocrinology, metabolism & nutrition
Pediatrics
Author, co-author :
Pinson, Anneline ;  Developmental Neuroendocrinology unit, GIGA Neurosciences, University of Liège, Quartier Hôpital, Tour 4, 1er étage, avenue Hippocrate 15, Liège, Belgium
Franssen, Delphine ;  Université de Liège - ULiège > R&D Direction : Chercheurs ULiège en mobilité
Gerard, Amaury ;  Université de Liège - ULiège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Chimie des agro-biosystèmes
Parent, Anne-Simone ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Bourguignon, Jean-Pierre ;  Université de Liège - ULiège > Département des sciences cliniques > Département des sciences cliniques
Language :
English
Title :
Neuroendocrine disruption without direct endocrine mode of action: Polychloro-biphenyls (PCBs) and bisphenol A (BPA) as case studies
Alternative titles :
[fr] Perturbation neuroendocrinienne sans mode d'action endocrinien direct: le cas des polychlorobiphényles (PCB) et du bisphénol A (BPA)
Publication date :
September 2017
Journal title :
Comptes Rendus Biologies
ISSN :
1631-0691
Publisher :
Elsevier Masson SAS
Volume :
340
Issue :
9-10
Pages :
432-438
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 09 February 2018

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