SHIP2

Inositol polyphosphate 5-phosphatase or phosphoinositide 5-phosphatases (or PI 5phosphatases)are enzymes that can act on inositol phosphates and/or phosphoinositides (PIs) as substrates to dephosphorylate the phosphate at 5 position of the inositol ring (Balla 2013). In human, it consists in a family of ten different isoenzymes (Blero et al. 2007). One of the first isoenzyme to be cloned was OCRL1 which is mutated in the Lowe syndrome and Dent-2 disease (Attree et al. 1992). Our interest in the family of PI 5phosphatases originated from the cloning of INPP5A (i.e., type 1 inositol 1,4,5-trisphosphate 5-phosphatase), a phosphatase that can act on soluble inositol phosphates, i.e., Ins(1,4,5)P3 and Ins(1,3,4,5)P4 as substrate