[en] Abstract
The objective of this retrospective study was to report the efficacy of a single daily oral dose of phenylpropanolamine (PPA) in the treatment of urethral sphincter mechanism incompetence (USMI) in bitches. Nine bitches diagnosed with USMI were treated with a single daily dose (1.5 mg/kg) of PPA for at least 1 month. Urethral pressure profiles (UPP) were performed in 7 dogs before treatment and repeated in 4 of them after treatment. Treatment with PPA resulted in long-term continence in 8/9 bitches. One dog did not respond to PPA and was treated surgically later. Recheck UPPs showed a significant increase in maximal urethral closure pressure in the 4 bitches after treatment with PPA compared to before treatment. In conclusion, long-term continence can be achieved in bitches affected with USMI after administration of a single daily dose of PPA (1.5 mg/kg).
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Claeys, Stéphanie ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Chirurgie des animaux de compagnie
Rustichelli, Federico
Noël, Stéphanie ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Chirurgie et clinique chirurgicale des petits animaux
Hamaide, Annick ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Chirurgie des animaux de compagnie
Language :
English
Title :
Clinical evaluation of a single daily dose of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch
Publication date :
May 2011
Journal title :
Canadian Veterinary Journal
ISSN :
0008-5286
Publisher :
Canadian Veterinary Medical Association, Ottawa, Canada
Holt PE. Urinary incontinence in the bitch due to sphincter mechanism incompetence: Prevalence in referred dogs and retrospective analysis of sixty cases. J Small Anim Pract 1985;26:181-190.
Holt PE. Urinary incontinence in dogs and cats. Vet Rec 1990; 127: 347-350.
Andersson KE. Pharmacology of lower urinary tract smooth muscles and penile erectile tissues. Pharmacol Rev 1993;45:253-308.
Auguet M, Delaflotte S, Chabrier P-E. Different al-adrenoreceptor subtypes mediate contraction in rabbit aotta and urethra. Eur J Pharmacol 1995;287:153-161.
Hashimoto S, Kigoshi S, Muramatsu I. Neurogenic responses of urethra isolated from the dog. Eur J Pharmacol 1992;213:117-123.
Collste L, Lindskog M. Phenylpropanolamine in treatment of female stress urinary incontinence. Double-blind placebo controlled study in 24 patients. Urology 1987:30:398-403. (Pubitemid 17149164)
Lehtonen T, Rannikko S, Lindell O, Talja M, Wuokko E, Lindskog M. The effects of phenylpropanolamine on female stress urinary incontinence. Ann Chir Gynaecol 1986;75:236-241. (Pubitemid 17187005)
Sullivan J, Abrams P. Pharmacological management of incontinence. Eur Urol 1999;36:89-95. (Pubitemid 29312921)
Scott L, Leddy M, Bernay F, Davot JL. Evaluation of phenylpropanolamine in the treatment of urethral sphincter mechanism incompetence in the bitch. J Small Anim Pract 2002;43:493-496. (Pubitemid 135748382)
White RAS, Pomeroy CJ. Phenylpropanolamine: An alpha-adrenergic agent fot the management of urinary incontinence in the bitch associated with urethral sphincter mechanism incompetence. Vet Rec 1989; 125:478-480. (Pubitemid 19270391)
Richter KP, Ling GV. Clinical response and urethral pressure profile changes after phenylpropanolamine in dogs with primary sphincter incompetence. J Am Vet Med Assoc 1985;187:605-611. (Pubitemid 15249465)
Boothe D. Principles of drug therapy. In: Boothe D, ed. Small Animal Clinical Pharmacology and Therapeutics. Philadelphia: WB Saunders, 2001:3-17.
DiBartola SP, Adams WM. Urinary incontinence associated with malposition of the urinary bladder. In: Kirk RW, ed. Current Veterinary Therapy VIII Small Animal Practice. Philadelphia: Saunders, 1983: 1089-1092.
Finkbeiner A, Bissida N. Drug therapy for lower urinary tract dysfunction. Urol Clin North Am 1980;7:3-16. (Pubitemid 10106065)
Moreau P, Lappin M. Pharmacologic management of micturition. In: Kirk R, Bonagura J, eds. Current Veterinary Therapy X Small Animal Practice. Philadelphia: WB Saunders, 1989:1214-1216.
Burgherr T, Reichler I, Hung L, Hubler M, Arnold S. Efficacy, tolerance and acceptability of Incontex in the context of spayed bitches with urinary incontinence. Schweiz Arch Tierheilkd 2007;149:307-313. (Pubitemid 47165478)
Blendinger C, Blendinger K, Bostedt H. Die Harninkontinenz nach Kastration bei der Hundin. 2. Mitteilung: Therapie. Tierarztl Prax 1995; 23:402-406.
Callahan S, Creed K. The effects of oestrogens on spontaneous activity and responses to phenylephrine of die mammalian urethra. J Physiol (Lond) 1985;358:35-46. (Pubitemid 15150533)
Collins S, Caron M, Leflcrowitz R. Regulation of adrenergic receptor responsiveness through modulation of receptor gene expression. Annu Rev Physiol 1991;53:497-508.
Lohse M. Molecular mechanisms of membrane receptor desensitization. Biochim Biophys Acta 1993;1179:171-188. (Pubitemid 23328720)
Gillberg PG, Fredrickson MG, Ohman BM, Alberts P. The effect of phenylpropanolamine on the urethral pressure and heart rate is retained after repeated short-term administration in the unanaesthetized, conscious dog. Scand J Urol Nephrol 1998;32:171-176. (Pubitemid 28326380)
Carofiglio F, Hamaide AJ, Farnir F, Balligand MH, Verstegen JP. Evaluation of the urodynamic and hemodynamic effects of orally administeted phenylpropanolamine and ephedrine in female dogs. Am J Vet Res 2006;67:723-730. (Pubitemid 44082184)
Noël S, Cambier C, Baert K, et al. Combined pharmacokinetic and urodynamic study of the effects of oral administration of phenylpropanolamine in female Beagle dogs. Vet J 2010;184:201-207.
Holt PE, Gibbs C, Wathes CM. Simultaneous urethral pressure profilometry using a microtip transducer catheter in the bitch: Effects of bitch position and transducer orientation. Neurourol Urodyn 1990; 9:281-296. (Pubitemid 20303907)
Hamaide AJ, Verstegen JP, Snaps FR, Onclin K, Balligand MH. Validation and comparison of the use of diuresis cystometry and retrograde filling cystometry at various infusion rates in female Beagle dogs. Am J Vet Res 2003;64:574-579. (Pubitemid 36575726)
International Continence Society. First report on the standardisation of terminology of lower urinary tract function. Br J Urol 1976;48:39-42.
Toews ML, Shreve PE, Bylund DB. Regulation of adrenergic receptors. In: Martinez JR, Edwards BS, Seagrave JC, eds. Signalling mechanisms in secretory and immune cells. San Francisco: San Francisco Pr, 1991:1-17.
Byron JK, March PA, DiBartola SP, Chew DJ, Muir WW. Comparison of the effect of propofol and sevoflurane on the urethral pressure profile in healthy female dogs. Am J Vet Res 2003;64:1288-1292. (Pubitemid 37236082)
Byron JK, March PA, Chew DJ, DiBartola SP. Effect of phenylpropanolamine and pseudoephedrine on the urethral pressure profile and continence scores of incontinent female dogs. J Vet Intern Med 2007; 21:47-53.
Krawiec DR. Diagnosis and treatment of acquired canine urinary incontinence. Companion Anim Pract 1989;19:12-20.
Krawiec DR, Rubin SI. Urinary incontinence in geriatric dogs. Compend Contin Educ Pract Vet 1985;7:557-563.
Rosin AH, Ross L. Diagnosis and pharmacological management of disorders of urinary continence in the dog. Compend Contin Educ Pract Vet 1981;3:601-610.
Kittelson M, Kienle R. Syncope. In: Kittelson M, Kienle R, eds. Small Animal Cardiovascular Medicine. St. Louis, Missouri: Mosby, 1998:495-501.
