Molecular Control of HIV and SIV Latency.

[en] The HIV latent reservoirs are considered as the main hurdle to viral eradication. Numerous mechanisms lead to the establishment of HIV latency and act at the transcriptional and post-transcriptional levels. A better understanding of latency is needed in order to ultimately achieve a cure for HIV. The mechanisms underlying latency vary between patients, tissues, anatomical compartments, and cell types. From this point of view, simian immunodeficiency virus (SIV) infection and the use of nonhuman primate (NHP) models that recapitulate many aspects of HIV-associated latency establishment and disease progression are essential tools since they allow extensive tissue sampling as well as a control of infection parameters (virus type, dose, route, and time).

Disciplines :

Immunology & infectious disease

Author, co-author :

DARCIS, Gilles ; Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne

Van Driessche, Benoit

Bouchat, Sophie

Kirchhoff, Frank

Van Lint, Carine

Language :

English

Title :

Molecular Control of HIV and SIV Latency.

Publication date :

2018

Journal title :

Current Topics in Microbiology and Immunology

ISSN :

0070-217X

Publisher :

Springer, Germany

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 17 January 2018

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