Article (Scientific journals)
Enantiomeric Separations of Drugs Using Mixtures of Charged and Neutral Cyclodextrins
Fillet, Marianne; Hubert, Philippe; Crommen, Jacques
2000In Journal of Chromatography. A, 875 (1-2), p. 123-34
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Abstract :
[en] An overview on the use of mixtures of neutral and charged cyclodextrins as chiral additives for the enantioseparation of drugs by capillary electrophoresis is presented. These so called dual cyclodextrin systems can often provide unique selectivities. A brief theoretical background illustrating the influence of the chiral discrimination ability and the effective mobility of the two cyclodextrins on the overall selectivity of the enantiomeric separation is given. Typical examples of applications in the pharmaceutical field, based on the simultaneous use of a charged (cationic or anionic) and neutral cyclodextrins, are described.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Fillet, Marianne ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Hubert, Philippe  ;  Université de Liège - ULiège > Chimie analytique
Crommen, Jacques ;  Université de Liège - ULiège > Département de pharmacie > Analyse des médicaments
Language :
English
Title :
Enantiomeric Separations of Drugs Using Mixtures of Charged and Neutral Cyclodextrins
Publication date :
14 April 2000
Journal title :
Journal of Chromatography. A
ISSN :
0021-9673
eISSN :
1873-3778
Publisher :
Elsevier, Amsterdam, Netherlands
Volume :
875
Issue :
1-2
Pages :
123-34
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 04 May 2010

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