Article (Scientific journals)
Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium
DE VOEGHT, Adrien; Martens, Henri; RENARD, Jeanne de Chantal et al.
2017In PLoS ONE
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Keywords :
HIV; sCD4; Thymus; TRECs; Microbial translocation
Abstract :
[en] Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and dβTRECs) were used as a measure of thymic function. Data were collected from 75 HIV-infected patients. Simple and complex linear regressions were done to analyze the link between these two processes. We found a statistically relevant negative correlation between thymopoiesis (sjTREC) and sCD14 level (p = 0.004). These results suggest a link between thymic function failure, microbial translocation and innate immune activation.
Research center :
GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège
Disciplines :
Immunology & infectious disease
Author, co-author :
DE VOEGHT, Adrien  ;  Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants
Martens, Henri ;  Université de Liège - ULiège > Centre d'immunologie
RENARD, Jeanne de Chantal ;  Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique
VAIRA, Dolorès ;  Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique
Debruche, Mathieu;  Centre Hospitalier Universitaire de Liège - CHU > Médecine
Simonet, Julie;  Centre Hospitalier Universitaire de Liège - CHU > Médecine
Geenen, Vincent ;  Université de Liège - ULiège > Centre d'immunologie
MOUTSCHEN, Michel  ;  Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne
DARCIS, Gilles ;  Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne
Language :
English
Title :
Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium
Publication date :
19 October 2017
Journal title :
PLoS ONE
eISSN :
1932-6203
Publisher :
Public Library of Science, San Franscisco, United States - California
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Available on ORBi :
since 05 December 2017

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