Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

DE VOEGHT, Adrien; Martens, Henri; RENARD, Jeanne de Chantal; VAIRA, Dolorès; Debruche, Mathieu; Simonet, Julie; Geenen, Vincent; MOUTSCHEN, Michel; DARCIS, Gilles

doi:10.1371/journal.pone.0185761

Article (Scientific journals)

Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

DE VOEGHT, Adrien; Martens, Henri; RENARD, Jeanne de Chantal et al.

2017 • In PLoS ONE

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/216657

DOI
10.1371/journal.pone.0185761

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29049344

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Keywords :

HIV; sCD4; Thymus; TRECs; Microbial translocation

Abstract :

[en] Microbial translocation is now viewed as a central event in the pathogenesis of chronic inflammation during HIV infection. Thymic function failure is another crucial factor involved in HIV disease progression. The goal of this study was to explore the hypothesis of potential links between microbial translocation and thymic function in HIV-1 patients living in Belgium. The extent of microbial translocation was assessed through the measurement of soluble CD14 (sCD14). T-cell receptor excision circles (sjTRECs and dβTRECs) were used as a measure of thymic function. Data were collected from 75 HIV-infected patients. Simple and complex linear regressions were done to analyze the link between these two processes. We found a statistically relevant negative correlation between thymopoiesis (sjTREC) and sCD14 level (p = 0.004). These results suggest a link between thymic function failure, microbial translocation and innate immune activation.

Research Center/Unit :

GIGA-I3 - Giga-Infection, Immunity and Inflammation - ULiège

Disciplines :

Immunology & infectious disease

Author, co-author :

DE VOEGHT, Adrien ; Centre Hospitalier Universitaire de Liège - CHU > Frais communs médecine - Pool assistants

Martens, Henri ; Université de Liège - ULiège > Centre d'immunologie

RENARD, Jeanne de Chantal ; Centre Hospitalier Universitaire de Liège - CHU > Service d'endocrinologie clinique

VAIRA, Dolorès ; Centre Hospitalier Universitaire de Liège - CHU > Service de microbiologie clinique

Debruche, Mathieu; Centre Hospitalier Universitaire de Liège - CHU > Médecine

Simonet, Julie; Centre Hospitalier Universitaire de Liège - CHU > Médecine

Geenen, Vincent ; Université de Liège - ULiège > Centre d'immunologie

MOUTSCHEN, Michel ; Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne

DARCIS, Gilles ; Centre Hospitalier Universitaire de Liège - CHU > Service des maladies infectieuses - médecine interne

Language :

English

Title :

Exploring the link between innate immune activation and thymic function by measuring sCD14 and TRECs in HIV patients living in Belgium

Publication date :

19 October 2017

Journal title :

PLoS ONE

eISSN :

1932-6203

Publisher :

Public Library of Science, San Franscisco, United States - California

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

https://doi.org/10.1371/journal.pone.0185761

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 05 December 2017

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