A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes.

Machiels, Bénédicte; Dourcy, Mickael; Xiao, Xue; Javaux, Justine; Mesnil, Claire; Sabatel, Catherine; Desmecht, Daniel; Lallemand, François; Martinive, Philippe; Hammad, Hamida; Guilliams, Martin; Dewals, Benjamin G; Vanderplasschen, Alain; Lambrecht, Bart N.; Bureau, Fabrice; Gillet, Laurent

doi:10.1038/ni.3857

Article (Scientific journals)

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes.

Machiels, Bénédicte; Dourcy, Mickael; Xiao, Xue et al.

2017 • In Nature Immunology

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https://hdl.handle.net/2268/216077

DOI
10.1038/ni.3857

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29035391

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Abstract :

[en] The hygiene hypothesis postulates that the recent increase in allergic diseases such as asthma and hay fever observed in Western countries is linked to reduced exposure to childhood infections. Here we investigated how infection with a gammaherpesvirus affected the subsequent development of allergic asthma. We found that murid herpesvirus 4 (MuHV-4) inhibited the development of house dust mite (HDM)-induced experimental asthma by modulating lung innate immune cells. Specifically, infection with MuHV-4 caused the replacement of resident alveolar macrophages (AMs) by monocytes with regulatory functions. Monocyte-derived AMs blocked the ability of dendritic cells to trigger a HDM-specific response by the TH2 subset of helper T cells. Our results indicate that replacement of embryonic AMs by regulatory monocytes is a major mechanism underlying the long-term training of lung immunity after infection.

Disciplines :

Microbiology

Author, co-author :

Machiels, Bénédicte ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire

Dourcy, Mickael ; Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Anatomie des animaux domestiques

Xiao, Xue ; Université de Liège - ULiège > Département des maladies infectieuses et parasitaires (DMI) > Vaccinologie vétérinaire

Javaux, Justine

Mesnil, Claire ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Sabatel, Catherine ; Université de Liège - ULiège > Département des sciences fonctionnelles (DSF) > GIGA-R : Biochimie et biologie moléculaire

Desmecht, Daniel ; Université de Liège - ULiège > Département de morphologie et pathologie (DMP) > Pathologie spéciale et autopsies

Lallemand, François ; Université de Liège - ULiège > Département des sciences cliniques > Radiothérapie

Martinive, Philippe ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Hammad, Hamida

More authors (6 more)

Language :

English

Title :

A gammaherpesvirus provides protection against allergic asthma by inducing the replacement of resident alveolar macrophages with regulatory monocytes.

Publication date :

2017

Journal title :

Nature Immunology

ISSN :

1529-2908

eISSN :

1529-2916

Publisher :

Nature Publishing Group, United Kingdom

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 15 November 2017

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