Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.

[en] Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET). Methods: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume. Results: [18F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship. Discussion: The cerebral distribution of [18F]UCB-H is similar to that recently observed with carbon-11 UCB-J ([11C]UCB-J). An accurate [18F]UCB-H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied in vivo in normal and pathological aging.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Bahri, Mohamed Ali ; Université de Liège > Centre de recherches du cyclotron > Centre de recherches du cyclotron

Plenevaux, Alain ; Université de Liège > Département de chimie (sciences) > Département de chimie (sciences)

Aerts, Joël ; Université de Liège > Département de pharmacie > Département de pharmacie

Bastin, Christine ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.

Becker, Guillaume ; Université de Liège > Centre de recherches du cyclotron

Mercier, Joël

Valade, Anne

Buchanan, Tim

Mestdagh, Nathalie

LEDOUX, Didier ; Centre Hospitalier Universitaire de Liège - CHU > Service des soins intensifs généraux

More authors (3 more)

Language :

English

Title :

Measuring brain synaptic vesicle protein 2A with positron emission tomography and [18F]UCB-H.

Publication date :

November 2017

Journal title :

Alzheimer's and Dementia: Translational Research and Clinical Interventions

eISSN :

2352-8737

Publisher :

Elsevier, New York, United States - New York

Volume :

Issue :

Pages :

481-486

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science/article/pii/S2352873717300501

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Available on ORBi :

since 12 September 2017

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