[en] Introduction: Brain distribution of synaptic vesicle protein 2Awas measured with fluorine-18 UCBH ([18F]UCB-H) and positron emission tomography (PET).
Methods: Images of synaptic density were acquired in healthy volunteers (two young participants and two seniors). Input function was measured by arterial blood sampling (arterial input function) and derived from PET images using carotid activity (image-derived input function). Logan graphical analysis was used to estimate regional synaptic vesicle protein 2A distribution volume.
Results: [18F]UCB-H uptake was ubiquitous in cortical and subcortical gray matter. Arterial input function and image-derived input function provided regional distribution volume with a high linear relationship.
Discussion: The cerebral distribution of [18F]UCB-H is similar to that recently observed with carbon-11 UCB-J ([11C]UCB-J). An accurate [18F]UCB-H quantification can be performed without invasive arterial blood sampling when no suitable reference region is available, using dynamic PET carotid activity. Brain synaptic density can be studied in vivo in normal and pathological aging.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Bahri, Mohamed Ali ; Université de Liège > Centre de recherches du cyclotron > Centre de recherches du cyclotron
Plenevaux, Alain ; Université de Liège > Département de chimie (sciences) > Département de chimie (sciences)
Aerts, Joël ; Université de Liège > Département de pharmacie > Département de pharmacie
Bastin, Christine ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Becker, Guillaume ; Université de Liège > Centre de recherches du cyclotron
Mercier, Joël
Valade, Anne
Buchanan, Tim
Mestdagh, Nathalie
LEDOUX, Didier ; Centre Hospitalier Universitaire de Liège - CHU > Service des soins intensifs généraux
Seret, Alain ; Université de Liège > Département de physique > Imagerie médicale expérimentale
Luxen, André ; Université de Liège > Département de chimie (sciences) > Laboratoire de chimie organique de synthèse
Salmon, Eric ; Université de Liège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
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