[en] Artemisia campestris is a perennial herb, commonly known as field wormwood. it is widespread in Asia, North America, Europe and north Africa. the different parts of this plant are used as anthelmintic, antidiabetic, antihypertensive, emmenagogue, antivenom, and to treat digestive and cutaneous problems. an exhaustive bibliographic research of this plant has been carried out by means of scientific engines and databases like Google scholar, PubMed, Sciencedirect and sciFinder; as a result, it has been found that this herb possesses a rich phytochemical content and a wide range of pharmacological activities such as antioxidant, antibacterial, antimutagenic , antivenom and antitumor effects. In an aim to highlight the importance of A. campestris L., this review has been established by discussing its ethnomedicinal, morphological, ecological, phytochemical, pharmacological and toxicological studies.
Disciplines :
Pharmacy, pharmacology & toxicology
Author, co-author :
Dib, Ikram
Angenot, Luc ; Université de Liège > Département de pharmacie > Département de pharmacie
Ziyyat, Abderrahim
Tits, Monique ; Université de Liège > Département de pharmacie > Département de pharmacie
Language :
English
Title :
Artemisia campestris L.:Ethnomedical, phytochemical and pharmacological review
Aicha, N., Ines, S., Mohamed, B.S., Ines, B., Soumaya, K., Kamel, G., et al. Chemical composition, mutagenic and antimutagenic activities of essential oils from (Tunisian) Artemisia campestris and Artemisia herba-alba. J. Essent. Oil Res. 20 (2008), 471–477.
Akkari, H., Rtibi, K., B'chir, F., Rekik, M., Darghouth, M.A., Gharbi, M., In vitro evidence that the pastoral Artemisia campestris species exerts an anthelmintic effect on Haemonchus contortus from sheep. Vet. Res. Commun. 38 (2014), 249–255.
Akrout, A., Chemli, R., Chreïf, I., Hammami, M., Analysis of the essential oil of Artemisia campestris L. Flavour Fragr J. 16 (2001), 337–339.
Akrout, A., Chemli, R., Simmonds, M., Kite, G., Hammami, M., Chreif, I., Seasonal variation of the essential oil of Artemisia campestris L. J. Essent. Oil Res. 15 (2003), 333–336.
Akrout, A., El Jani, H., Amouri, S., Neffati, M., Screening of antiradical and antibacterial activities of essential oils of Artemisia campestris L., Artemisia herba alba Asso, & Thymus capitatus Hoff: et Link. growing wild in the southern of Tunisia. Rec. Res. Sci. Tech. 2 (2010), 29–39.
Akrout, A., Gonzalez, L.A., El Jani, H., Madrid, P.C., Antioxidant and antitumor activities of Artemisia campestris and Thymelaea hirsuta from southern Tunisia. Food Chem. Toxicol. 49 (2011), 342–347.
Akrout, A., Neffati, M., Chemli, R., Aouni, M., Jerraya, R., Dammak, M., et al. Composition chimique et activités biologiques de l'huile essentielle d'Artemisia campestris L. Revue des Régions Arides 1 (2007), 231–240.
Aniya, Y., Shimabukuro, M., Shimoji, M., Kohatsu, M., Gyamfi, M.A., Miyagi, C., et al. Antioxidant and hepatoprotective actions of the medicinal herb Artemisia campestris from the Okinawa Islands. Biol. Pharm. Bull. 23 (2000), 309–312.
Bahekar, S., Kale, R., Nagpure, S., A review on medicinal plants used in scorpion bite treatment in India. Int. J. Pharm. Med. Sci. 1 (2012), 1–6.
Bakchiche, B., Gherib, A., Activités antioxydantes des polyphenols extraits de plantes médicinales de la pharmacopée traditionnelle d'Algérie [Antioxidant activities of polyphenol extracts from medicinal plants in Algerian traditional pharmacopoeia]. Int. J. Innov. Appl. Stud. 9 (2014), 167–172.
Barkat, L., Boumendjel, A., Messarah, M., PM2-161: Protective effects of an aqueous extract of Artemisia campestris against methidathion-induced hepatotoxicity in male Wistar rats. Fundam. Clin. Pharmacol., 28, 2014 89–89.
Baykan Erel, Ş., Reznicek, G., Şenol, S.G., Karabay Yavaşoğulu, N.Ü., Konyalioğlu, S., Zeybek, A.U., Antimicrobial and antioxidant properties of Artemisia L. species from western Anatolia. Turk. J. Biol. 36 (2012), 75–84.
Belhattab, R., Boudjouref, M., Barroso, J., Pedro, L., Figueiredo, A., Essential oil composition from Artemisia campestris grown in Algeria. Adv. Environ. Biol. 5 (2011), 429–432.
Bellomaria, B., Valentini, G., Biondi, E., Chemotaxonomy of artemisia variabilis ten: and A. campestris L. ssp. glutinosa (Ten.) briq. et cavill. (Asteraceae) from Italy. J. Essent. Oil Res. 13 (2001), 90–94.
Ben Sassi, A., Harzallah-Skhiri, F., Aouni, M., Investigation of some medicinal plants from Tunisia for antimicrobial activities. Pharm. Biol. 45 (2007), 421–428.
Benítez, G., González-Tejero, M., Molero-Mesa, J., Pharmaceutical ethnobotany in the western part of Granada province (southern Spain): ethnopharmacological synthesis. J. Ethnopharmacol. 129 (2010), 87–105.
Ben-Nasr, H., Salama, M., Ksouda, K., Zeghal, K.M., Hammami, S., Hemodynamic effects of aqueous extract of Artemisia campestris in adult men. J. Appl. Pharm. Sci. 4 (2014), 38–42.
Benchelah, A.-C., Bouziane, H., Maka, M., Fleurs du Sahara, arbres et arbustes, voyage au coeur de leurs usages avec les Touaregs du Tassili. Phytothérapie 2 (2004), 191–197.
Bnouham, M., Mekhfi, H., Legssyer, A., Ziyyat, A., Ethnopharmacology forum medicinal plants used in the treatment of diabetes in Morocco. Int. J. Diabetes Metab. 10 (2002), 33–50.
Boudjelal, A., Henchiri, C., Sari, M., Sarri, D., Hendel, N., Benkhaled, A., et al. Herbalists and wild medicinal plants in M'Sila (North Algeria): An ethnopharmacology survey. J. Ethnopharmacol. 148 (2013), 395–402.
Boulanouar, B., Abdelaziz, G., Aazza, S., Gago, C., Miguel, M.G., Antioxidant activities of eight Algerian plant extracts and two essential oils. Ind. Crops Prod. 46 (2013), 85–96.
Cariñanos, P., de la Guardia, C.D., Algarra, J.A., De Linares, C., Irurita, J.M., The pollen counts as bioindicator of meteorological trends and tool for assessing the status of endangered species: the case of Artemisia in Sierra Nevada (Spain). Clim. Change 119 (2013), 799–813.
Carvalho, I.S., Teixeira, M., Brodelius, M., Fatty acids profile of selected Artemisia spp: plants: Health promotion. LWT-Food Sci. Technol. 44 (2011), 293–298.
Chalchat, J.-C., Cabassu, P., Petrovic, S., Maksimovic, Z., Gorunovic, M., Composition of essential oil of Artemisia campestris L. from Serbia. J. Essent. Oil Res. 15 (2003), 251–253.
D'Andrea, S., Caramiello, R., Ghignone, S., Siniscalco, C., Systematic studies on some species of the genus Artemisia: biomolecular analysis. Plant Biosyst 137 (2003), 121–130.
De Lamarck, J.-B., De Candolle, A.P., Flore française, ou descriptions succinctes deToutes les plantes qui croissent naturellement en France: disposées selon une nouvelle Méthode d'Analyse, et Précédées par un exposé des principes élémentaires de la botanique. Tome 4., 3ème édition, 1815, Agasse, Paris.
De Natale, A., Pollio, A., A forgotten collection: the libyan ethnobotanical exhibits (1912-14) by A. trotter at the museum O. comes at the university federico II in naples, Italy. J. Ethnobiol. Ethnomed. 8 (2012), 1–19.
De Pascual Teresa, J., Gonzalez, M.S., Muriel, M.R., Bellido, I.S., 2-Methyl-2-hydroxymethylchromenes from Artemisia campestris subsp. glutinosa. Phytochemistry 22 (1983), 2587–2589.
De Pascual Teresa, J., Gonzalez, M., Muriel, M., Arcocha, A., Bellido, I., Flavonoids from Artemisia campestris ssp glutinosa. J. Nat. Prod., 49, 1986 177–177.
Djeridane, A., Yousfi, M., Nadjemi, B., Boutassouna, D., Stocker, P., Vidal, N., Antioxidant activity of some Algerian medicinal plants extracts containing phenolic compounds. Food Chem. 97 (2006), 654–660.
Djeridane, A., Yousfi, M., Nadjemi, B., Vidal, N., Lesgards, J., Stocker, P., Screening of some Algerian medicinal plants for the phenolic compounds and their antioxidant activity. Eur. Food. Res. Technol. 224 (2007), 801–809.
Djeridane, A., Yousfi, M., Brunel, J.M., Stocker, P., Isolation and characterization of a new steroid derivative as a powerful antioxidant from Cleome arabica in screening the in vitro antioxidant capacity of 18 Algerian medicinal plants. Food Chem. Toxicol. 48 (2010), 2599–2606.
Djidel, S., Khennouf, S., Radical scavenging, reducing power, lipid peroxidation inhibition and chelating properties of extracts from Artemisia campestris L. Aerial parts. Annu. Res. Rev. Biol. 4 (2014), 1691–1702.
Djidel, S., Khennouf, S., Baghiani, A., Harzallah, D., Arrar, L., Medicinal plants used traditionally in the Algerian folk medicine for gastrointestinal disorders and hypertension: total polyphenols, flavonoids and antioxidant activity. Acta Hortic 854 (2009), 59–65.
Dob, T., Dahmane, D., Berramdane, T., Chelghoum, C., Chemical composition of the essential oil of Artemisia campestris.L. from Algeria. Pharm. Biol. 43 (2005), 512–514.
El Abed, N., Guesmi, F., Mejri, M., Marzouki, M., Ben Hadj Ahmed, S., Phytochemical screening and assessment of antioxidant, antibacterial and cytotoxicty activities of five Tunisian medicinal plants. Int. J. Pharm. Res. Biosci. 3 (2014), 770–789.
El Bahri, L., Belguith, J., Djegham, M., Bellil, H., Artemisia campestris L: a poisonous plant of north africa. Vet. Hum. Toxicol. 39 (1997), 311–312.
El Hassani, M., Douiri, E.M., Bammi, J., Zidane, L., Badoc, A., Douira, A., Plantes médicinales de la moyenne moulouya (Nord-Est du Maroc). Ethnopharmacologia 50 (2013), 39–53.
El-Mokasabi, F.M., Floristic composition and traditional uses of plant species at Wadi Alkuf, Al-Jabal Al-Akhder, Libya. Am Eurasian J Agric Environ Sci 14 (2014), 685–697.
Emery, S.M., Rudgers, J.A., Ecological assessment of dune restorations in the Great Lakes region. Restor. Ecol. 18 (2010), 184–194.
Erel, Ş.B., Şenol, S.G., Köse, F.A., Ballar, P., In vitro cytotoxic properties of six Artemisia L. species. Turk. J. Pharm. Sci. 8 (2011), 247–252.
Fakchich, J., Elachouri, M., Ethnobotanical survey of medicinal plants used by people in Oriental Morocco to manage various ailments. J. Ethnopharmacol. 154 (2014), 76–87.
Ferchichi, L., Merza, J., Landreau, A., Le Ray, A.M., Legseir, B., Seraphin, D., et al. Occurrence of isocoumarinic and phenolic derivatives in Artemisia campestris L. subsp campestris. Biochem. Syst. Ecol. 34 (2006), 829–832.
Ghorab, H., Laggoune, S., Kabouche, A., Semra, Z., Kabouche, Z., Essential oil composition and antibacterial activity of Artemisia campestris L. from Khenchela (Algeria). Pharm. Lett. 5 (2013), 189–192.
Gillet, C.-C., Magne, J.-H., Nouvelle Flore Française, Descriptions Succintes Et Rangées Par Tableaux Dichotomiques Des Plantes Qui Croissent Spontanément En France Et Celles Qu'on Y Cultive En Grand Avec l'Indication De Leurs Propriétés Et De Leur Usages En Médecine, En Hygiène Vétérinaire, Dans Les Arts Et Dans l'Economie Domestique Paris. 1863, Garnier Frères, Libraires-Editeurs.
González, A.G., Bermejo, J., Estévez, F., Velázquez, R., Phenolic derivatives from Artemisia glutinosa. Phytochemistry 22 (1983), 1515–1516.
Guarino, C., De Simone, L., Santoro, S., Ethnobotanical study of the Sannio area, Campania, Southern Italy. Ethnobot. Res. Appl. 6 (2008), 255–317.
Hammiche, V., Maiza, K., Traditional medicine in central sahara: pharmacopoeia of tassili N'ajjer. J. Ethnopharmacol. 105 (2006), 358–367.
Hurabielle, M., Eberle, J., Paris, M., Etude des flavonoïdes d'Artemisia campestris sous-espèce Glutinosa [Flavonoids of Artemisia campestris, ssp glutinosa]. Planta Med. 46 (1982), 124–125.
Judzentiene, A., Budiene, J., Variability of Artemisia campestris L. essential oils from Lithuania. J. Essent. Oil Res. 26 (2014), 328–333.
Judzentiene, A., Budiene, J., Butkiene, R., Kupcinskiene, E., Laffont-Schwob, I., Masotti, V., Caryophyllene oxide-rich essential oils of Lithuanian Artemisia campestris ssp: campestris and their toxicity. Nat. Prod. Commun. 5 (2010), 1981–1984.
Juteau, F., Masotti, V., Bessière, J.-M., Viano, J., Compositional characteristics of the essential oil of Artemisia campestris var glutinosa. Biochem. Syst. Ecol. 30 (2002), 1065–1070.
Kapoor, S., Saraf, S., Topical herbal therapies an alternative and complementary choice to combat acne. Res. J. Med. Plant 5 (2011), 650–669.
Karabegović, I., Nikolova, M., Veličković, D., Stojičević, S., Veljković, V., Lazić, M., Comparison of antioxidant and antimicrobial activities of methanolic extracts of the Artemisia sp: recovered by different extraction techniques. Chin. J. Chem. Eng. 19 (2011), 504–511.
Kawada, K., Suzuki, K., Suganuma, H., Smaoui, A., Isoda, H., Plant biodiversity in the semi-arid zone of Tunisia. J. Arid Land Stud. 22 (2012), 83–86.
Kazemi, M., Tabatabaei-Anaraki, M., Rustaiyan, A., Motevalizadeh, A., Masoudi, S., Chemical composition of the essential oils obtained from the flower, leaf and stem of Artemisia campestris L. from Iran. J. Essent. Oil Res. 21 (2009), 197–199.
Khalilov, L., Paramonov, E., Khalilova, A., Odinokov, V., Muldashev, A., Baltaev, U., et al. Identification and biological activity of volatile organic compounds emitted by plants and insects: IV.Composition of vapor isolated from certain species of Artemisia plants. Chem Nat Prod 37 (2001), 339–342.
Kreitschitz, A., Vallès, J., New or rare data on chromosome numbers in several taxa of the genus Artemisia (Asteraceae) in Poland. Folia Geobot 38 (2003), 333–343.
Kreitschitz, A., Vallès, J., Achene morphology and slime structure in some taxa of Artemisia L. and Neopallasia L. (Asteraceae). Flora 202 (2007), 570–580.
Kujawska, M., Hilgert, N.I., Phytotherapy of Polish migrants in Misiones, Argentina: legacy and acquired plant species. J. Ethnopharmacol. 153 (2014), 810–830.
Le Houerou, H., Eco-climatic and bio-geographic comparison between the rangelands of the iso-climatic Mediterranean arid zone of northern Africa and the Near East. Omar, S., Razzaque, M., Alsdirawi, F., (eds.) Range Management in Arid Zones, 2013, Routledge, New York, 25–40.
Leporatti, M.L., Ghedira, K., Comparative analysis of medicinal plants used in traditional medicine in Italy and Tunisia. J. Ethnobiol. Ethnomed. 5 (2009), 1–8.
Lis, A., Kowal, M., Constituents of the essential oils from different organs of Artemisia campestris L. subsp. campestris. J. Essent. Oil Res., 2015, 1–6.
Masotti, V., De Jong, L., Moreau, X., Rabier, J., Laffont-Schwob, I., Thiéry A. Larvicidal activity of extracts from Artemisia species against Culex pipiens L. mosquito: comparing endemic versus ubiquist species for effectiveness. C. R. Biol. 335 (2012), 19–25.
Megdiche-Ksouri, W., Trabelsi, N., Mkadmini, K., Bourgou, S., Noumi, A., Snoussi, M., et al. Artemisia campestris phenolic compounds have antioxidant and antimicrobial activity. Ind. Crops Prod. 63 (2015), 104–113.
Minami, M., Suzuki, M., Hosokawa, K., Kondo, S., Oka, K., Shibata, T., Preliminary survey of taxonomical problems, pharmacognostical characteristics, and chloroplast DNA polymorphisms of the folk medicinal herb Artemisia campestris from the Ryukyu Islands, Japan. J. Nat. Med. 64 (2010), 239–244.
Mucciarelli, M., Caramiello, R., Maffei, M., Chialva, F., Essential oils from some Artemisia species growing spontaneously in North-West Italy. Flavour Fragr. J. 10 (1995), 25–32.
Naghibi, F., Khalaj, A., Mosaddegh, M., Malekmohamadi, M., Hamzeloo-Moghadam, M., Cytotoxic activity evaluation of some medicinal plants, selected from Iranian traditional medicine Pharmacopoeia to treat cancer and related disorders. J. Ethnopharmacol. 155 (2014), 230–239.
Naili, M.B., Alghazeer, R.O., Saleh, N.A., Al-Najjar, A.Y., Evaluation of antibacterial and antioxidant activities of Artemisia campestris (Astraceae) and Ziziphus lotus (Rhamnacea). Arab. J. Chem. 3 (2010), 79–84.
Nobis, M., Ebel, A.L., Nowak, A., Turginov, O.T., Kupriyanov, A.N., Nobis, A., et al. Contribution to the flora of Asian and European countries: new national and regional vascular plant records, 2. Acta Bot. Gall. 161 (2014), 209–221.
Noumi, Z., Ouled Dhaou, S., Derbel, S., Chaieb, M., The status of Asteraceae in the arid and saharian flora of North African region: case of Tunisia. Pak. J. Bot. 42 (2010), 1417–1422.
Novák, J., Konvička, M., Proximity of valuable habitats affects succession patterns in abandoned quarries. Ecol. Eng. 26 (2006), 113–122.
Ouyahya, A., Clé de détermination des espèces marocaines du genre Artemisia L. Al Biruniya Rev. Mar. Pharm. 6 (1990), 31–91.
Pascual-Villalobos, M., Robledo, A., Screening for anti-insect activity in Mediterranean plants. Ind. Crops Prod. 8 (1998), 183–194.
Pavela, R., Larvicidal effects of some Euro-Asiatic plants against Culex quinquefasciatus Say larvae (Diptera: culicidae). Parasitol. Res. 105 (2009), 887–892.
Pirini Chrisoula, B., Tsiripidis, I., Bergmeier, E., Steppe-like grass land vegetation in the hills around the lakes of Vegoritida and Petron, North-Central Greece. Hacquetiap, 121, 2014.
Popović, Z., Smiljanić, M., Matić, R., Kostić, M., Nikić, P., Bojović, S., Phytotherapeutical plants from the Deliblato Sands (Serbia): traditional pharmacopoeia and implications for conservation. Indian J. Tradit. Knowl. 11 (2012), 385–400.
Quézel, P., Santa, S., Artemisia L. nouvelle flore de l'Algérie et des Régions Désertiques Méridionales. Tome, II ed., 1962, C.N.R.S, Paris, 988–990 (Armoise).
Réthy, B., Csupor‐Löffler, B., Zupkó, I., Hajdú, Z., Máthé, I., Hohmann, J., et al. Antiproliferative activity of Hungarian Asteraceae species against human cancer cell lines. Part I. Phytother. Res. 21 (2007), 1200–1208.
Rebbas, K., Bounar, R., Études floristique et ethnobotanique des plantes médicinales de la région de M'sila (Algérie). Phytothérapie 12 (2014), 284–291.
Riedel, H., Cai, Z., Smetanska, I., Obtaining phenolic acids from cell cultures of various Artemisia species. Afr. J. Biotechnol. 9 (2010), 8805–8809.
Saadaoui, I., Ilahi, H., Robin, B.C., Rejeb, H., Contribution to the study of the flora in the central-west of Tunisia: landscape dynamics and evaluation of plant biodiversity of mountain Bouchebka. Int. J. Innov. Appl. Stud. 6 (2014), 257–268.
Salinas, M.J., Guirado, J., Riparian plant restoration in summer-dry riverbeds of Southeastern Spain. Restor. Ecol. 10 (2002), 695–702.
Saoudi, M., Allagui, M.S., Abdelmouleh, A., Jamoussi, K., El Feki, A., Protective effects of aqueous extract of Artemisia campestris against puffer fish Lagocephalus lagocephalus extract-induced oxidative damage in rats. Exp. Toxicol. Pathol. 62 (2010), 601–605.
Sebai, H., Jabri, M.-A., Souli, A., Hosni, K., Selmi, S., Tounsi, H., et al. Protective effect of Artemisia campestris extract against aspirin-induced gastric lesions and oxidative stress in rat. RSC Adv. 4 (2014), 49831–49841.
Sefi, M., Fetoui, H., Makni, M., Zeghal, N., Mitigating effects of antioxidant properties of Artemisia campestris leaf extract on hyperlipidemia, advanced glycation end products and oxidative stress in alloxan-induced diabetic rats. Food Chem. Toxicol. 48 (2010), 1986–1993.
Sefi, M., Troudi, A., Hamida, F., Soudani, N., Boudawara, T., Zeghal, N., Protective effects of Artemisia campestris upon fenthion-induced nephrotoxicity in adult rats and their progeny. Gen. Physiol. Biophys. 32 (2013), 577–588.
Shemluck, M., Medicinal and other uses of the compositae by Indians in the United States and Canada. J. Ethnopharmacol. 5 (1982), 303–358.
Silva, A., Seca, A., Vasconcelos, J., Cavaleiro, J., Silvestre, A., Domingues, F., et al. Chemical composition of Artemisia campestris and Hibiscus cannabinus. Rauter, A.P., Palma, F.B., Justino, J., Araujo, M.E., Pina dos Santos, S., (eds.) Natural Products in the New Millennium: Prospects and Industrial Application, 2002, Springer, Berlin, Heidelberg, 47–57.
Silvestre, A., Silva, A., Almeida, L., Pereira, C., Cavaleiro, J., The essential oil of Artemisia campestris L. subsp maritima Arcangelis. Acta Hortic. 500 (1999), 93–96.
Subally, D., Quézel, P., Glacial or interglacial: artemisia, a plant indicator with dual responses. Rev. Palaeobot. Palynol. 120 (2002), 123–130.
Tharib, S.M., Gnan, S.O., Veitch, G.B.A., Antimicrobial activity of compounds from Artemisia campestris. J. Food Prot. 46 (1983), 185–187.
Tlili, N., Elfalleh, W., Hannachi, H., Yahia, Y., Khaldi, A., Ferchichi, A., et al. Screening of natural antioxidants from selected medicinal plants. Int. J. Food Prop. 16 (2013), 1117–1126.
Turesson, G., The plant species in relation to habitat and climate contributions to the knowledge of genecological units. Hereditas 6 (1925), 147–236.
Vahdati-Mashhadian, N., Emami, S., Oghazian, M., Vosough, R., The cytotoxicity evaluation of seven species of Artemisia on human tumor cell lines. Pharmacologyonline 1 (2009), 229–242.
Valant-Vetschera, K.M., Fischer, R., Wollenweber, E., Exudate flavonoids in species of Artemisia (Asteraceae—Anthemideae): new results and chemosystematic interpretation. Biochem. Syst. Ecol. 31 (2003), 487–498.
Vasconcelos, J.M.J., Silva, A.M.S., Cavaleiro, J.A.S., Chromones and flavanones from Artemisia campestris subsp maritima. Phytochemistry 49 (1998), 1421–1424.
Webster, D., Taschereau, P., Belland, R.J., Sand, C., Rennie, R.P., Antifungal activity of medicinal plant extracts; preliminary screening studies. J. Ethnopharmacol. 115 (2008), 140–146.
Zabka, M., Pavela, R., Gabrielova-Slezakova, L., Promising antifungal effect of some Euro-Asiatic plants against dangerous pathogenic and toxinogenic fungi. J. Sci. Food Agric. 91 (2011), 492–497.
