Article (Scientific journals)
HC gp-39 gene is upregulated in glioblastomas.
Shostak, Kateryna; Labunskyy, Vyacheslav; Dmitrenko, Vladimir et al.
2003In Cancer Letters, 198 (2), p. 203-10
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Keywords :
Adipokines; Astrocytoma/genetics/pathology; Blotting, Northern; Brain/cytology/physiology; Brain Neoplasms/classification/genetics/pathology; Breast Neoplasms/genetics; Chitinase-3-Like Protein 1; Female; Gene Expression Regulation, Neoplastic; Genome, Human; Glioblastoma/genetics/pathology; Glycoproteins; Humans; Lectins/genetics; Neoplasm Staging; Reference Values; Tumor Cells, Cultured
Abstract :
[en] Public databases of the Cancer Genome Anatomy Project were used to quantify the relative gene expression levels in glioblastoma multiforme (GBM) and normal brain by Serial Analysis of Gene Expression (SAGE). Analysis revealed HC gp-39 among the genes with the most pronounced changes of expression in tumor cells. Northern hybridization confirmed the results of computer analysis and showed that enhanced expression of the HC gp-39 gene was mainly in GBMs and occasionally in anaplastic astrocytomas. Neither SAGE nor Northern analysis revealed the presence of HC gp-39 mRNA in the glioblastoma cell line, thus the detection of increased quantities of this mRNA in GBMs may be associated with activated macrophages. Since the numbers of infiltrating macrophages and small vessel density are higher in glioblastomas than in anaplastic astrocytomas or astrocytomas, the HC gp-39 gene can be used as a molecular marker in the analysis of malignant progression of astrocytic gliomas.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Shostak, Kateryna ;  Université de Liège > Département de pharmacie > Chimie médicale
Labunskyy, Vyacheslav
Dmitrenko, Vladimir
Malisheva, Tatiana
Shamayev, Michail
Rozumenko, Vladimir
Zozulya, Yuriy
Zehetner, Gunter
Kavsan, Vadym
Language :
English
Title :
HC gp-39 gene is upregulated in glioblastomas.
Publication date :
2003
Journal title :
Cancer Letters
ISSN :
0304-3835
eISSN :
1872-7980
Publisher :
Elsevier, Netherlands
Volume :
198
Issue :
2
Pages :
203-10
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 02 June 2017

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