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  | Li, C., Moro, S., Shostak, K., O'Reilly, F. J., Donzeau, M., Graziadei, A., McEwen, A. G., Desplancq, D., Poussin-Courmontagne, P., Bachelart, T., Fiskin, M., Berrodier, N., Pichard, S., Brillet, K., Orfanoudakis, G., Poterszman, A., Torbeev, V., Rappsilber, J., Davey, N. E., ... Zanier, K. (03 September 2024). Molecular mechanism of IKK catalytic dimer docking to NF-κB substrates. Nature Communications, 15 (1), 7692. doi:10.1038/s41467-024-52076-0  Peer Reviewed verified by ORBi |
 | Wathieu, C., Lavergne, A., Xu, X., Rolot, M., Nemazanyy, I., Shostak, K., El Hachem, N., Maurizy, C., Leemans, C., Close, P., Nguyen, L., Desmet, C., Tielens, S.* , Dewals, B. G.* , & Chariot, A.*. (2024). Loss of Elp3 blocks intestinal tuft cell differentiation via an mTORC1-Atf4 axis. EMBO Journal. doi:10.1038/s44318-024-00184-4 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | El Hachem, N., Leclercq, M., Susaeta Ruiz, M., Vanleyssem, R., Shostak, K., Körner, P.-R., Capron, C., Martin Morales, L., RONCARATI, P., Lavergne, A., Blomme, A., Turchetto, S., Goffin, E., Thandapani, P., Tarassov, I., Nguyen, L., Pirotte, B., Chariot, A., Marine, J.-C., ... Close, P. (2024). Valine aminoacyl-tRNA synthetase promotes therapy resistance in melanoma. Nature Cell Biology. doi:10.1038/s41556-024-01439-2 Peer Reviewed verified by ORBi |
Lion, Q., Wen, X., Shostak, K., Vanleyssem, R., Close, P., Dejardin, E., & Chariot, A. (06 September 2022). ROLE OF THE tRNA-MODIFYING ENZYME ELONGATOR IN LIVER [Poster presentation]. GIGA DAY 2022. |
 | Chen, D., Nemazanyy, I., Peulen, O., Shostak, K., Xu, X., Tang, S. C., Wathieu, C., Turchetto, S., Tielens, S., Nguyen, L., Close, P., Desmet, C., Klein, S., Florin, A., Büttner, R., Petrellis, G., Dewals, B. G., & Chariot, A. (2022). Elp3-mediated codon-dependent translation promotes mTORC2 activation and regulates macrophage polarization. EMBO Journal, 109353. doi:10.15252/embj.2021109353 Peer Reviewed verified by ORBi |
Wathieu, C., Tielens, S., Lavergne, A., Shostak, K., Rolot, M., El Hachem, N., Xu, X., Close, P., Nguyen, L., Desmet, C., Dewals, B. G., & CHARIOT, A. (10 May 2022). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Paper presentation]. Type 2 Immunity in Early Life Symposium, Liège, Belgium. |
  | Tang, S. C., Lion, Q., Peulen, O., Chariot, P., Lavergne, A., Mayer, A., Allepuz Fuster, P., Close, P., Klein, S., Florin, A., Büttner, R., Nemazanyy, I., Shostak, K., & Chariot, A. (29 January 2022). The E3 ligase COP1 promotes ERα signaling and suppresses EMT in breast cancer. Oncogene, 41, 173-190. doi:10.1038/s41388-021-02038-3 Peer Reviewed verified by ORBi |
 | Jeschke, J., Collignon, E., Al Wardi, C., Krayem, M., Bizet, M., Jia, Y., Garaud, S., Wimana, Z., Calonne, E., Hassabi, B., Morandini, R., Deplus, R., Putmans, P., Dube, G., Singh, N. K., Koch, A., Shostak, K., Rizzotto, L., Ross, R. L., ... Fuks, F. (June 2021). Downregulation of the FTO m6A RNA demethylase promotes EMT-mediated progression of epithelial tumors and sensitivity to Wnt inhibitors. Nature Cancer, 2 (6), 611-628. doi:10.1038/s43018-021-00223-7 Peer reviewed |
 | Rapino, F.* , ZHOU, Z.* , RONCERO SANCHEZ, A. M.* , Joiret, M., Seca, C., El Hachem, N., Valenti, G., Latini, S., Shostak, K., Geris, L., Li, P., Huang, G., Mazzucchelli, G., Baiwir, D., Desmet, C., Chariot, A., Georges, M., & Close, P. (2021). Wobble tRNA modification and hydrophilic amino acid patterns dictate protein fate. Nature Communications, 12 (1), 2170. doi:10.1038/s41467-021-22254-5 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Shostak, K., Wathieu, C., Tielens, S., & Chariot, A. (2021). NF-κB Signaling in Ex-Vivo Mouse Intestinal Organoids. Methods in Molecular Biology, 2366, 283-292. doi:10.1007/978-1-0716-1669-7_17 Peer reviewed |
 | Shostak, K., Jiang, Z., CHARLOTEAUX, B., Mayer, A., Habraken, Y., Tharun, L., Klein, S., Xu, X., Duong, H. Q., Vislovukh, A., Close, P., Florin, A., Rambow, F., Marine, J.-C., Büttner, R., & Chariot, A. (09 March 2020). The X-linked trichothiodystrophy-causing gene RNF113A links the spliceosome to cell survival upon DNA damage. Nature Communications, 11 (1). doi:10.1038/s41467-020-15003-7 Peer Reviewed verified by ORBi |
Wathieu, C., Tielens, S., Rolot, M., Shostak, K., Close, P., Dewals, B. G., & CHARIOT, A. (16 October 2018). A role for the tRNA-modifying enzyme Elp3 in tuft cell differentiation and in the immune response in the intestine [Poster presentation]. EMBO workshop "From epigenome towards epitranscriptome in cell fate choice", Capri, Italy. |
 | Rapino, F., Delaunay, S., Rambow, F., Zhou, Z., Tharun, L., De Tullio, P., Sin, O., Shostak, K., Schmitz, S., Piepers, J., Guesquière, B., Karim, L., Charloteaux, B., Jamart, D., Florin, A., Lambert, C., RORIVE, A., JERUSALEM, G., Leucci, E., ... Close, P. (28 June 2018). Codon-specific translation reprogramming promotes resistance to targeted therapy. Nature, 558, 605-609. doi:10.1038/s41586-018-0243-7 Peer Reviewed verified by ORBi |
 | Duong, H. Q., Nemazanyy, I., Rambow, F., Tang, S. C., Delaunay, S., Tharun, L., Florin, A., Büttner, R., VAN DAELE, D., Close, P., Marine, J.-C., Shostak, K., & Chariot, A. (2018). The endosomal protein CEMIP links Wnt signaling to MEK1-ERK1/2 activation in Selumetinib-resistant intestinal organoids. Cancer Research, 10.1158/0008-5472.CAN-17-3149. doi:10.1158/0008-5472.CAN-17-3149 Peer Reviewed verified by ORBi |
 | Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Desmet, C., Nguyen, L., Leiden, S. A., Willis, A. E., Buettner, R., Chariot, A., & Close, P. (October 2016). ELP3 links tRNA modification to IRES-dependent translation of LEF-1 to promote metastasis in breast cancer. Journal of Experimental Medicine, 213, 2503-2523. doi:10.1084/jem.20160397 Peer Reviewed verified by ORBi |
Delaunay, S., Rapino, F., Tharun, L., Zhou, Z., Heukamp, L., Termathe, M., Shostak, K., Klevernic, I., Florin, A., Desmecht, H., Nguyen, L., Leidel, S., Willis, A., Chariot, A., & Close, P. (May 2016). tRNA modification: Elogator sustains Breast cancer metastasis [Paper presentation]. Invitation pour une présentation au Stem Cell Institute - Cambridge University, Cambridge, United Kingdom. |
 | Boerboom, A., Dion, V., Pieltain, A., Shostak, K., Chariot, A., & Franzen, R. (May 2016). KIAA1199 links ErbB signalling to Schwann cell development and plasticity [Poster presentation]. Gordon seminar + conference Myelin. |
Delaunay, S., Rapino, F., Zhou, Z., Shostak, K., LADANG, A., Chariot, A., & Close, P. (25 January 2016). tRNA modification: Elogator promotes metastasis in breast cancer [Paper presentation]. GIGA-DAY 2016, Liège, Belgium. |
 | Göktuna, S., Shostak, K., Chau, T.-L., Heukamp, L., Hennuy, B., Duong, H. Q., LADANG, A., Close, P., Klevernic, I., Olivier, F., Florin, A., Ehx, G., Baron, F., Vandereyken, M., Rahmouni, S., Vereecke, L., van Loo, G., Büttner, R., Greten, F., & Chariot, A. (2016). The Prosurvival IKK-Related Kinase IKK« Integrates LPS and IL17A Signaling Cascades to Promote Wnt-Dependent Tumor Development in the Intestine. Cancer Research, 76, 2587-99. doi:10.1158/0008-5472.CAN-15-1473 Peer Reviewed verified by ORBi |
 | LADANG, A.* , Rapino, F.* , Heukamp, L., Tharun, L., Shostak, K., Hermand, D., Delaunay, S., Klevernic, I., Jiang, Z., Jacques, N., Jamart, D., Migeot, V., Florin, A., Göktuna, S., Malgrange, B., Samson, O., Nguyen, L., Buettner, R., Close, P., & Chariot, A. (16 November 2015). Elp3 drives Wnt-dependent tumor initiation and regeneration in the intestine. Journal of Experimental Medicine, 212 (12), 2057-75. doi:10.1084/jem.20142288 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Shostak, K., & Chariot, A. (June 2015). EGFR and NF-kB: partners in cancer. Trends in Molecular Medicine, 21, 385-393. doi:10.1016/j.molmed.2015.04.001 Peer Reviewed verified by ORBi |
Delaunay, S., Rapino, F., Zhou, Z., LADANG, A., Shostak, K., Chariot, A., & Close, P. (09 March 2015). Elongator: mcm5s2 modification fosters breast cancer metastasis [Paper presentation]. MRC toxicology meeting, Leicester, United Kingdom. |
 | Chau, T.-L., Göktuna, S., Rammal, A., Casanova Bustos, T. R., Duong, H. Q., GATOT, J.-S., Close, P., Dejardin, E., Desmecht, D., Shostak, K., & Chariot, A. (2015). A role for APPL1 in tlr3/4-dependent TBK1 and IKKε activation in macrophages. Journal of Immunology. doi:10.4049/jimmunol.1401614 Peer Reviewed verified by ORBi |
 | Delaunay, S., Heukamp, L., Zhou, Z., Shostak, K., LADANG, A., Jiang, Z., Nguyen, L., Chariot, A., & Close, P. (08 May 2014). Elongator drives breast cancer initiation and metastasis formation [Poster presentation]. ENBDC meeting 2014, Weggis, Switzerland. |
 | Shostak, K.* , Patrascu, F.* , Göktuna, S., Close, P., Borgs, L., Nguyen, L., Olivier, F., Rammal, A., Brinkhaus, H., Bentires-Alj, M., Marine, J.-C., & Chariot, A. (May 2014). MDM2 restrains estrogen-mediated AKT activation by promoting TBK1-dependent HPIP degradation. Cell Death and Differentiation, 5 (21), 811-24. doi:10.1038/cdd.2014.2 Peer Reviewed verified by ORBi* These authors have contributed equally to this work. |
 | Shostak, K., Zhang, X., Hubert, P., Göktuna, S., Jiang, Z., Klevernic, I., Hildebrand, J., Roncarati, P., Hennuy, B., Ladang, A., SOMJA, J., Gothot, A., Close, P., Delvenne, P., & Chariot, A. (2014). NF-kappaB-induced KIAA1199 promotes survival through EGFR signalling. Nature Communications, 5, 5232. doi:10.1038/ncomms6232 Peer Reviewed verified by ORBi |
 | Stellzig, J., Chariot, A., Shostak, K., Göktuna, S., Renner, F., Acker, T., Pagenstecher, A., & Schmitz, M. (11 November 2013). Deregulated expression of TANK in glioblastomas triggers pro-tumorigenic ERK1/2 and AKT signaling pathways. Observatoire (L'), e79. doi:10.1038/oncsis.2013.42 Peer reviewed |
 | Shostak, K., & Chariot, A. (26 July 2011). NF-kB, stem cells and breast cancer: the links get stronger. Breast Cancer Research, 13 (4), 214. doi:10.1186/bcr2886 Peer Reviewed verified by ORBi |
 | Keutgens, A., Shostak, K., Close, P., Zhang-Shao, X., Hennuy, B., Aussems, M., Chapelle, J.-P., Viatour, P., Gothot, A., Fillet, M., & Chariot, A. (August 2010). The repressing function of the oncoprotein BCL-3 requires CtBP while its polyubiquitination and degradation involve the E3 ligase TBLR1. Molecular and Cellular Biology, 30, 4006-4021. doi:10.1128/MCB.01600-09 Peer Reviewed verified by ORBi |
 | Keutgens, A., Zhang-Shao, X., Shostak, K., Robert, I., Olivier, S., Vanderplasschen, A., Chapelle, J.-P., Viatour, P., Merville, M.-P., Bex, F., Gothot, A., & Chariot, A. (2010). BCL-3 degradation involves its polyubiquitination through a FBW7-independent pathway and its binding to the proteasome subunit PSMB1. Journal of Biological Chemistry, 285 (33), 25831–25840. doi:10.1074/jbc.M110.112128 Peer Reviewed verified by ORBi |
 | Kavsan, V., Shostak, K., Dmitrenko, V., Zozulya, Y., Rozumenko, V., & Demotes-Mainard, J. (2005). Characterization of genes with increased expression in human glioblastomas. Tsitologiia i Genetika, 39 (6), 37-49. Peer reviewed |
 | Dmitrenko, V., Shostak, K., Boyko, O., Khomenko, O., Rozumenko, V., Malisheva, T., Shamayev, M., Zozulya, Y., & Kavsan, V. (2005). Reduction of the transcription level of the mitochondrial genome in human glioblastoma. Cancer Letters, 218 (1), 99-107. doi:10.1016/j.canlet.2004.07.001 Peer Reviewed verified by ORBi |
 | Shostak, K., Dmitrenko, V. V., Garifulin, O. M., Rozumenko, V. D., Khomenko, O. V., Zozulya, Y. A., Zehetner, G., & Kavsan, V. M. (2003). Downregulation of putative tumor suppressor gene TSC-22 in human brain tumors. Journal of Surgical Oncology, 82 (1), 57-64. doi:10.1002/jso.10180 Peer Reviewed verified by ORBi |
 | Shostak, K., Labunskyy, V., Dmitrenko, V., Malisheva, T., Shamayev, M., Rozumenko, V., Zozulya, Y., Zehetner, G., & Kavsan, V. (2003). HC gp-39 gene is upregulated in glioblastomas. Cancer Letters, 198 (2), 203-10. doi:10.1016/S0304-3835(03)00310-0 Peer Reviewed verified by ORBi |
