Reference : IkappaBzeta: an emerging player in cancer.
Scientific journals : Article
Life sciences : Genetics & genetic processes
http://hdl.handle.net/2268/206591
IkappaBzeta: an emerging player in cancer.
English
Willems, Marie [> >]
Dubois, Nadege [> >]
Musumeci, Lucia [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences >]
Bours, Vincent mailto [Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine >]
Robe, Pierre mailto [Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
2016
Oncotarget
7
40
66310-66322
Yes
International
1949-2553
United States
[en] IkappaBzeta ; NF-kappaB pathway ; cancer ; nuclear IkappaB protein ; perspectives
[en] IkappaBzeta, an atypical member of the nuclear IkappaB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFkappaB-dependent pathway. Like its homolog Bcl3, IkappaBzeta can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-kappaB. Long studied as a key component of the immune response, IkappaBzeta emerges as an important regulator of inflammation, cell proliferation and survival. As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies.
http://hdl.handle.net/2268/206591
10.18632/oncotarget.11624

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