IkappaBzeta: an emerging player in cancer.

[en] IkappaBzeta, an atypical member of the nuclear IkappaB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFkappaB-dependent pathway. Like its homolog Bcl3, IkappaBzeta can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-kappaB. Long studied as a key component of the immune response, IkappaBzeta emerges as an important regulator of inflammation, cell proliferation and survival. As a result, growing evidence support the role of this transcription factor in the pathogenesis number of human hematological and solid malignancies.

Disciplines :

Genetics & genetic processes

Author, co-author :

Willems, Marie

Dubois, Nadège ; Centre Hospitalier Universitaire de Liège - CHU > Département ULiège > Faculté de médecine

Musumeci, Lucia ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : GIGA - Cardiovascular Sciences

Bours, Vincent ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

Robe, Pierre ; Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Language :

English

Title :

IkappaBzeta: an emerging player in cancer.

Publication date :

2016

Journal title :

Oncotarget

eISSN :

1949-2553

Publisher :

Impact Journals, United States - New York

Volume :

Issue :

Pages :

66310-66322

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 31 January 2017

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