MicroRNAs and Inflammation in Colorectal Cancer.

[en] Colorectal cancers (CRC) are known to be related to inflammatory conditions, and inflammatory bowel diseases increase the relative risk for developing CRC. The use of anti-inflammatory drugs prevents the development of colorectal cancer.Several molecular mediators are connecting the pathways that are involved in inflammatory conditions and in carcinogenesis. By the way these pathways are tightly interwoven, with the consequence that a deregulation at the level of any of these molecular mediators can affect the others.MiRNAs are demonstrated to be deregulated in inflammatory bowel diseases and in colorectal cancer. Moreover, they target several molecular mediators that connect inflammation to cancer, and they are thus implicated in the route from inflammation to colorectal cancer.This chapter will focus on the miRNAs that are jointly deregulated in inflammatory bowel disease and in colorectal cancer. Their role on the regulation of the molecular mediators and pathways that link inflammation to cancer will be described.

Disciplines :

Gastroenterology & hepatology

Author, co-author :

Josse, Claire ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

Bours, Vincent ; Université de Liège > Département des sciences biomédicales et précliniques > GIGA-R : Génétique humaine

Language :

English

Title :

MicroRNAs and Inflammation in Colorectal Cancer.

Publication date :

2016

Main work title :

Non-coding RNAs in Colorectal Cancer

Author, co-author :

Slaby, Ondrej

Calin, George A.

Publisher :

Springer, Switzerland

Edition :

1° éd.

ISBN/EAN :

9783319420592

Collection name :

Advances in Experimental Medicine and Biology 937

Pages :

53-69

Peer reviewed :

Peer reviewed

Available on ORBi :

since 11 October 2016

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Bibliography

Friedman, R.C., Farh, K.K.-H., Burge, C.B., Bartel, D.P., Most mammalian mRNAs are conserved targets of microRNAs (2009) Genome Res, 19, pp. 92-105
Sonkoly, E., Pivarcsi, A., MicroRNAs in inflammation (2009) Int Rev Immunol, 28, pp. 535-561
Hayes, J., Peruzzi, P.P., Lawler, S., MicroRNAs in cancer: Biomarkers, functions and therapy (2014) Trends Mol Med, pp. 1-10
Mantovani, A., Allavena, P., Sica, A., Balkwill, F., Cancerrelated inflammation (2008) Nature, 454, pp. 436-444
Cuzick, J., Otto, F., Baron, J.A., Brown, P.H., Burn, J., Greenwald, P., Aspirin and non-steroidal antiinflammatory drugs for cancer prevention: An international consensus statement (2009) Lancet Oncol, 10, pp. 501-507
Rigas, B., Tsioulias, G.J., The evolving role of nonsteroidal anti-inflammatory drugs in colon cancer prevention: A cause for optimism (2015) J Pharmacol Exp Ther, 353, pp. 2-8
Ek, W.E., D’Amato, M., Halfvarson, J., The history of genetics in inflammatory bowel disease (2014) Ann Gastroenterol Q Publ Hell Soc Gastroenterol, 27, pp. 294-303
Herszényi, L., Barabás, L., Miheller, P., Tulassay, Z., Colorectal cancer in patients with inflammatory bowel disease: The true impact of the risk (2015) Dig Dis, 33, pp. 52-57
Goel, A., MicroRNAs as therapeutic targets in colitis and colitis-associated cancer: Tiny players with a giant impact (2015) Gastroenterology, 149, pp. 859-861
Schetter, A.J., Heegaard, N., Harris, C.C., Inflammation and cancer: Interweaving microRNA, free radical, cytokine and p53 pathways (2010) Carcinogenesis, 31, pp. 37-49
Francescone, R., Hou, V., Grivennikov, S.I., Cytokines, IBD, and colitis-associated cancer (2015) Inflamm Bowel Dis, 21, pp. 409-418
Bregenzer, N., Hartmann, A., Strauch, U., Schölmerich, J., Us, T., Bollheimer, L.C., Increased insulin resistance and beta cell activity in patients with Crohn’s disease (2006) Inflamm Bowel Dis, 12, pp. 53-56
Lawrance, I.C., Maxwell, L., Doe, W., Inflammation location, but not type, determines the increase in TGF-beta1 and IGF-1 expression and collagen deposition in IBD intestine (2001) Inflamm Bowel Dis, 7, pp. 16-26
Shirakami, Y., Shimizu, M., Kubota, M., Araki, H., Tanaka, T., Moriwaki, H., Chemoprevention of colorectal cancer by targeting obesity-related metabolic abnormalities (2014) World J Gastroenterol, 20, pp. 8939-8946
Gallagher, E.J., Leroith, D., The proliferating role of insulin and insulin-like growth factors in cancer (2010) Trends Endocrinol Metab, 21, pp. 610-618
Cuthbert, A.P., Fisher, S.A., Mirza, M.M., King, K., Hampe, J., Croucher, P., The contribution of NOD2 gene mutations to the risk and site of disease in inflammatory bowel disease (2002) Gastroenterology, 122, pp. 867-874
Danielsen, S.A., Eide, P.W., Nesbakken, A., Guren, T., Leithe, E., Lothe, R.A., Portrait of the PI3K/AKT pathway in colorectal cancer (2015) Biochim Biophys Acta, 1855, pp. 104-121
Zhang, J., Roberts, T.M., Shivdasani, R.A., Targeting PI3K signaling as a therapeutic approach for colorectal cancer (2011) Gastroenterology, 141, pp. 50-61
Ben-Neriah, Y., Karin, M., Inflammation meets cancer, with NF-κB as the matchmaker (2011) Nat Immunol, 12, pp. 715-723
Colotta, F., Allavena, P., Sica, A., Garlanda, C., Mantovani, A., Cancer-related inflammation, the seventh hallmark of cancer: Links to genetic instability (2009) Carcinogenesis, 30, pp. 1073-1081
Kukitsu, T., Takayama, T., Miyanishi, K., Nobuoka, A., Katsuki, S., Sato, Y., Aberrant crypt foci as precursors of the dysplasia-carcinoma sequence in patients with ulcerative colitis (2008) Clin Cancer Res, 14, pp. 48-54
Cooks, T., Pateras, I.S., Tarcic, O., Solomon, H., Schetter, A.J., Wilder, S., Mutant p53 prolongs NF-κB activation and promotes chronic inflammation and inflammation-associated colorectal cancer (2013) Cancer Cell, 23, pp. 634-646
Levy, N., Yonish-Rouach, E., Oren, M., Kimchi, A., Complementation by wild-type p53 of interleukin-6 effects on M1 cells: Induction of cell cycle exit and cooperativity with c-myc suppression (1993) Mol Cell Biol, 13, pp. 7942-7952
Brighenti, E., Calabrese, C., Liguori, G., Giannone, F.A., Trerè, D., Montanaro, L., Interleukin 6 downregulates p53 expression and activity by stimulating ribosome biogenesis: A new pathway connecting inflammation to cancer (2014) Oncogene, 33, pp. 4396-4406
Claessen, M.M.H., Schipper, M., Oldenburg, B., Siersema, P.D., Offerhaus, G., Vleggaar, F.P., WNTpathway activation in IBD-associated colorectal carcinogenesis: Potential biomarkers for colonic surveillance (2010) Cell Oncol, 32, pp. 303-310
Roos, J., Grösch, S., Werz, O., Schröder, P., Ziegler, S., Fulda, S., Regulation of tumorigenic Wnt signaling by cyclooxygenase-2, 5-lipoxygenase and their pharmacological inhibitors: A basis for novel drugs targeting cancer cells? (2015) Pharmacol Ther
Tao, S., Tang, D., Morita, Y., Sperka, T., Omrani, O., Lechel, A., Wnt activity and basal niche position sensitize intestinal stem and progenitor cells to DNA damage (2015) EMBO J, 34, pp. 624-640
Yu, C.-H., Nguyen, T., Irvine, K.M., Sweet, M.J., Frazer, I.H., Blumenthal, A., Recombinant Wnt3a and Wnt5a elicit macrophage cytokine production and tolerization to microbial stimulation via Toll-like receptor4 (2014) Eur J Immunol, 44, pp. 1480-1490
Meira, L.B., Bugni, J.M., Green, S.L., Lee, C., Pang, B., Borenshtein, D., DNA damage induced by chronic inflammation contributes to colon carcinogenesis in mice (2008) J Clin Invest, 118, pp. 2516-2525
Kalla, R., Ventham, N.T., Kennedy, N.A., Quintana, J.F., Nimmo, E.R., Buck, A.H., MicroRNAs: New play-ers in IBD (2015) Gut, 64, pp. 504-513
De Robertis, M., Massi, E., Poeta, M.L., Carotti, S., Morini, S., Cecchetelli, L., The AOM/DSS murine model for the study of colon carcinogenesis: From pathways to diagnosis and therapy studies [Internet] (2011) J Carcinog, 9p
Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z.-W., Egan, L.J., IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer (2004) Cell, 118, pp. 285-296
Josse, C., Bouznad, N., Geurts, P., Irrthum, A., Huynh-Thu, V.A., Servais, L., Identification of a microRNA landscape targeting the PI3K/Akt signaling pathway in inflammation-induced colorectal carcinogenesis (2014) Am J Physiol Gastrointest Liver Physiol, 306, pp. G229-G243
Liu, S.-Q., Jiang, S., Li, C., Zhang, B., Li, Q.-J., MiR-17-92 cluster targets phosphatase and tensin homology and Ikaros Family Zinc Finger 4 to promote TH17-mediated inflammation (2014) J Biol Chem, 289, pp. 12446-12456
Kanaan, Z., Rai, S.N., Eichenberger, M.R., Barnes, C., Dworkin, A.M., Weller, C., Differential microRNA expression tracks neoplastic progression in inflammatory bowel disease-associated colorectal cancer (2012) Hum Mutat, 33, pp. 551-560
Curtale, G., Mirolo, M., Renzi, T.A., Rossato, M., Bazzoni, F., Locati, M., Negative regulation of Toll-like receptor 4 signaling by IL-10-dependent microRNA-146b (2013) Proc Natl Acad Sci U S A, 110, pp. 11499-11504
Olivo-Marston, S.E., Hursting, S.D., Perkins, S.N., Schetter, A., Khan, M., Croce, C., Effects of calorie restriction and diet-induced obesity on murine colon carcinogenesis, growth and inflammatory factors, and microRNA expression (2014) Plos One, 9
Bian, Z., Li, L., Cui, J., Zhang, H., Liu, Y., Zhang, C.-Y., Role of miR-150-targeting c-Myb in colonic epithelial disruption during dextran sulphate sodiuminduced murine experimental colitis and human ulcerative colitis (2011) J Pathol, 225, pp. 544-553
Zhang, Y., Liu, D., Chen, X., Li, J., Li, L., Bian, Z., Secreted monocytic miR-150 enhances targeted endothelial cell migration (2010) Mol Cell, 39, pp. 133-144
Singh, U.P., Murphy, A.E., Enos, R.T., Shamran, H.A., Singh, N.P., Guan, H., MiR-155 deficiency protects mice from experimental colitis by reducing T helper type 1/type 17 responses (2014) Immunology, 143, pp. 478-489
Schetter, A.J., Leung, S.Y., Sohn, J.J., Zanetti, K.A., Bowman, E.D., Yanaihara, N., MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinoma (2008) JAMA, 299, pp. 425-436
Iliopoulos, D., Jaeger, S.A., Hirsch, H.A., Bulyk, M.L., Struhl, K., STAT3 activation of miR-21 and miR-181b-1 via PTEN and CYLD are part of the epigenetic switch linking inflammation to cancer (2010) Mol Cell, 39, pp. 493-506
Shi, C., Yang, Y., Xia, Y., Okugawa, Y., Yang, J., Liang, Y., Novel evidence for an oncogenic role of microRNA-21 in colitis-associated colorectal cancer (2015) Gut, pp. 1-12
Schaefer, J.S., Montufar-Solis, D., Vigneswaran, N., Klein, J.R., Selective upregulation of microRNA expression in peripheral blood leukocytes in IL-10−/− mice precedes expression in the colon (2011) J Immunol, 187, pp. 5834-5841
Hofsli, E., Sjursen, W., Prestvik, W.S., Johansen, J., Rye, M., Tranø, G., Identification of serum microRNA profiles in colon cancer (2013) Br J Cancer, 108, pp. 1712-1719
Brain, O., Owens, B., Pichulik, T., Allan, P., Khatamzas, E., Leslie, A., The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release (2013) Immunity, 39, pp. 521-536
Wu, L., Li, H., Jia, C.Y., Cheng, W., Yu, M., Peng, M., MicroRNA-223 regulates FOXO1 expression and cell proliferation (2012) FEBS Lett, 586, pp. 1038-1043
Jia, C.Y., Li, H.H., Zhu, X.C., Dong, Y.W., Fu, D., Zhao, Q.L., MiR-223 suppresses cell proliferation by targeting IGF-1R (2011) Plos One, 6
Nian, W., Ao, X., Wu, Y., Huang, Y., Shao, J., Wang, Y., MiR-223 functions as a potent tumor suppressor of the Lewis lung carcinoma cell line by targeting insulin-like growth factor-1 receptor and cyclin-dependent kinase2 (2013) Oncol Lett, 6, pp. 359-366
Pan, Y., Liang, H., Liu, H., Li, D., Chen, X., Li, L., Platelet-secreted microRNA-223 promotes endothelial cell apoptosis induced by advanced glycation end products via targeting the insulin-like growth factor 1 receptor (2014) J Immunol, 192, pp. 437-446
Chuang, A.Y., Chuang, J.C., Zhai, Z., Wu, F., Kwon, J.H., NOD2 expression is regulated by microRNAs in colonic epithelial HCT116 cells (2014) Inflamm Bowel Dis, 20, pp. 126-135
Taganov, K.D., Boldin, M.P., Chang, K.-J., Baltimore, D., NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses (2006) Proc Natl Acad Sci U S A, 103, pp. 12481-12486
Noguchi, S., Yasui, Y., Iwasaki, J., Kumazaki, M., Yamada, N., Naito, S., Replacement treatment with microRNA-143 and −145 induces synergistic inhibition of the growth of human bladder cancer cells by regulating PI3K/Akt and MAPK signaling pathways (2013) Cancer Lett, 328, pp. 353-361
Barbáchano, A., Fernández-Barral, A., Pereira, F., Segura, M.F., Ordóñez-Morán, P., Carrillo-De Santa Pau, E., SPROUTY-2 represses the epithelial phenotype of colon carcinoma cells via upregulation of ZEB1 mediated by ETS1 and miR-200/miR-150 (2015) Oncogene
Bandrés, E., Cubedo, E., Agirre, X., Malumbres, R., Zárate, R., Ramirez, N., Identification by Realtime PCR of 13 mature microRNAs differentially expressed in colorectal cancer and non-tumoral tissues (2006) Mol Cancer, 5, p. 29
Chen, X., Guo, X., Zhang, H., Xiang, Y., Chen, J., Yin, Y., Role of miR-143 targeting KRAS in colorectal tumorigenesis (2009) Oncogene, 28, pp. 1385-1392
Polytarchou, C., Hommes, D.W., Palumbo, T., Hatziapostolou, M., Koutsioumpa, M., Koukos, G., MicroRNA214 is associated with progression of ulcerative colitis, and inhibition reduces development of colitis and colitis-associated cancer in mice (2015) Gastroenterology, 49, pp. 981–92. e11
Polytarchou, C., Iliopoulos, D., Struhl, K., An integrated transcriptional regulatory circuit that reinforces the breast cancer stem cell state (2012) Proc Natl Acad Sci U S A, 109, pp. 14470-14475
Wang, Y., Tang, Q., Li, M., Jiang, S., Wang, X., MicroRNA-375 inhibits colorectal cancer growth by targeting PIK3CA (2014) Biochem Biophys Res Commun, 444, pp. 199-204
Mao, Q., Quan, T., Luo, B., Guo, X., Liu, L., Zheng, Q., MiR-375 targets KLF4 and impacts the proliferation of colorectal carcinoma (2015) Tumor Biol
Ghaleb, A.M., Laroui, H., Merlin, D., Yang, V.W., Genetic deletion of Klf4 in the mouse intestinal epithelium ameliorates dextran sodium sulfate-induced colitis by modulating the NF-κB pathway inflammatory response (2014) Inflamm Bowel Dis, 20, pp. 811-820
Lee, H.-Y., Ahn, J.B., Rha, S.Y., Chung, H.C., Park, K.H., Kim, T.S., High KLF4 level in normal tissue predicts poor survival in colorectal cancer patients (2014) World J Surg Oncol, 12, p. 232
Tili, E., Croce, C.M., Michaille, J.-J., MiR-155: On the crosstalk between inflammation and cancer (2009) Int Rev Immunol, 28, pp. 264-284
Chae, Y.S., Kim, J.G., Lee, S.J., Kang, B.W., Lee, Y.J., Park, J.Y., A miR-146a polymorphism (Rs2910164) predicts risk of and survival from colorectal cancer (2013) Anticancer Res, 33, pp. 3233-3239
Koukos, G., Polytarchou, C., Kaplan, J.L., Morley-Fletcher, A., Gras-Miralles, B., Kokkotou, E., MicroRNA-124 regulates STAT3 expression and is down-regulated in colon tissues of pediatric patients with ulcerative colitis (2013) Gastroenterology, 145, pp. 842–52. e2
Lujambio, A., Ropero, S., Ballestar, E., Fraga, M.F., Cerrato, C., Setién, F., Genetic unmasking of an epigenetically silenced microRNA in human cancer cells (2007) Cancer Res, 67, pp. 1424-1429
Ueda, Y., O, T., Nanjo, S., Ushijima, T., Sugiyama, T., DNA methylation of microRNA-124a is a potential risk marker of colitis-associated cancer in patients with ulcerative colitis (2014) Dig Dis Sci, 59, pp. 2444-2451
Chen, Q., Wang, H., Liu, Y., Song, Y., Lai, L., Han, Q., Inducible microRNA-223 down-regulation promotes TLR-triggered IL-6 and IL-1β production in macrophages by targeting STAT 3 (2012) Plos One, 7
Rokavec, M., Öner, M.G., Li, H., Jackstadt, R., Jiang, L., Lodygin, D., IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis (2014) J Clin Invest, 124, pp. 1853-1867
Mathé, E., Nguyen, G.H., Funamizu, N., He, P., Moake, M., Croce, C.M., Inflammation regulates microRNA expression in cooperation with p53 and nitric oxide (2012) Int J Cancer, 131, pp. 760-765
Li, W., Han, W., Ma, Y., Cui, L., Tian, Y., Zhou, Z., P53-dependent miRNAs mediate nitric oxideinduced apoptosis in colonic carcinogenesis (2015) Free Radic Biol Med, 85, pp. 105-113
Sachdeva, M., Zhu, S., Wu, F., Wu, H., Walia, V., Kumar S, et al. P53 represses c-Myc through induction of the tumor suppressor miR-145 (2009) Proc Natl Acad Sci U S A, 106, pp. 3207-3212
Masciarelli, S., Fontemaggi, G., Di Agostino, S., Donzelli, S., Carcarino, E., Strano, S., Gain-offunction mutant p53 downregulates miR-223 contributing to chemoresistance of cultured tumor cells (2014) Oncogene, 33, pp. 1601-1608
He, L., He, X., Lim, L.P., De Stanchina, E., Xuan, Z., Liang, Y., A microRNA component of the p53 tumour suppressor network (2007) Nature, 447, pp. 1130-1134
Wang, M., Zhang, P., Li, Y., Liu, G., Zhou, B., Zhan, L., The quantitative analysis by stem-loop realtime PCR revealed the microRNA-34a, microRNA-155 and microRNA-200c overexpression in human colorectal cancer (2012) Med Oncol, 29, pp. 3113-3118
Hiyoshi, Y., Schetter, A.J., Okayama, H., Inamura, K., Anami, K., Nguyen, G.H., Increased microRNA-34b and-34c predominantly expressed in stromal tissues is associated with poor prognosis in human colon cancer (2015) Plos One, 10
Arndt, G.M., Dossey, L., Cullen, L.M., Lai, A., Druker, R., Eisbacher, M., Characterization of global microRNA expression reveals oncogenic potential of miR-145 in metastatic colorectal cancer (2009) BMC Cancer, 9, p. 374
Monzo, M., Navarro, A., Bandres, E., Artells, R., Moreno, I., Gel, B., Overlapping expression of microRNAs in human embryonic colon and colorectal cancer (2008) Cell Res, 18, pp. 823-833
Akao, Y., Nakagawa, Y., Hirata, I., Iio, A., Itoh, T., Kojima, K., Role of anti-oncomirs miR-143 and −145 in human colorectal tumors (2010) Cancer Gene Ther, 17, pp. 398-408
Roy, S., Levi, E., Majumdar, A., Sarkar, F.H., Expression of miR-34 is lost in colon cancer which can be re-expressed by a novel agent CDF (2012) J Hematol Oncol, 5, p. 58
O’Donnell, K.A., Wentzel, E.A., Zeller, K.I., Dang, C.V., Mendell, J.T., C-Myc-regulated microRNAs modulate E2F1 expression (2005) Nature, 435, pp. 839-843
Pickering, M.T., Stadler, B.M., Kowalik, T.F., MiR-17 and miR-20a temper an E2F1-induced G1 checkpoint to regulate cell cycle progression (2008) Oncogene, 28, pp. 140-145
Davidson-Moncada, J., Papavasiliou, F.N., Tam, W., MicroRNAs of the immune system: Roles in inflammation and cancer (2010) Ann N Y Acad Sci, 1183, pp. 183-194
Zhu, H., Dougherty, U., Robinson, V., Mustafi, R., Pekow, J., Kupfer, S., EGFR signals downregulate tumor suppressors miR-143 and miR-145 in Western dietpromoted murine colon cancer: Role of G1 regulators (2011) Mol Cancer Res, 9, pp. 960-975
Christensen, L.L., Holm, A., Rantala, J., Kallioniemi, O., Rasmussen, M.H., Ostenfeld, M.S., Functional screening identifies miRNAs influencing apoptosis and proliferation in colorectal cancer (2014) Plos One, 9
Gregorieff, A., Liu, Y., Inanlou, M.R., Khomchuk, Y., Wrana, J.L., Yap-dependent reprogramming of Lgr5+ stem cells drives intestinal regeneration and cancer (2015) Nature, 526, pp. 715-718
Liang, L., Zhu, J., Zaorsky, N.G., Deng, Y., Wu, X., Liu, Y., MicroRNA-223 enhances radiation sensitivity of U87MG cells in vitro and in vivo by targeting ataxia telangiectasia mutated (2014) Int J Radiat Oncol, 88, pp. 955-960
Tabet, F., Vickers, K.C., Cuesta Torres, L.F., Wiese, C.B., Shoucri, B.M., Lambert, G., HDL-transferred microRNA-223 regulates ICAM-1 expression in endothelial cells (2014) Nat Commun, 5, p. 3292
Ismail, N., Wang, Y., Dakhlallah, D., Moldovan, L., Agarwal, K., Batte, K., Macrophage microvesicles induce macrophage differentiation and miR-223 transfer (2013) Blood, 121, pp. 984-995
Liu, Q., Zhang, M., Jiang, X., Zhang, Z., Dai, L., Min, S., MiR-223 suppresses differentiation of tumorinduced CD11b + Gr1 + myeloid-derived suppressor cells from bone marrow cells (2011) Int J Cancer, 129, pp. 2662-2673
Toh, B., Wang, X., Keeble, J., Sim, W.J., Khoo, K., Wong, W.-C., Mesenchymal transition and dissemination of cancer cells is driven by myeloidderived suppressor cells infiltrating the primary tumor (2011) Plos Biol, 9
Knudsen, K.N., Nielsen, B.S., Lindebjerg, J., Hansen, T.F., Holst, R., Sørensen, F.B., MicroRNA-17 is the most upregulated member of the miR-17-92 cluster during early colon cancer evolution (2015) Plos One, 10
Ng, E., Tsang, W.P., Ng, S., Jin, H.C., Yu, J., Li, J.J., MicroRNA-143 targets DNA methyltransferases 3A in colorectal cancer (2009) Br J Cancer, 101, pp. 699-706
Gaedcke, J., Grade, M., Camps, J., Sokilde, R., Kaczkowski, B., Schetter, A.J., The rectal cancer microRNAome-microRNA expression in rectal cancer and matched normal mucosa (2012) Clin Cancer Res, 18, pp. 4919-4930
Motoyama, K., Inoue, H., Takatsuno, Y., Tanaka, F., Mimori, K., Uetake, H., Over-and underexpressed microRNAs in human colorectal cancer (2009) Int J Oncol, 34, pp. 1069-1075
Volinia, S., Calin, G.A., Liu, C., Ambs, S., Cimmino, A., Petrocca, F., A microRNA expression signature of human solid tumors defines cancer gene targets (2006) Proc Natl Acad Sci U S A, 103, pp. 2257-2261
Liu, M., Chen, H., The role of microRNAs in colorectal cancer (2010) J Genet Genomics, 37, pp. 347-358
Pekow, J.R., Dougherty, U., Mustafi, R., Zhu, H., Kocherginsky, M., Rubin, D.T., MiR-143 and miR-145 are downregulated in ulcerative colitis: Putative regulators of inflammation and protooncogenes (2012) Inflamm Bowel Dis, 18, pp. 94-100
Faltejskova, P., Svoboda, M., Srutova, K., Mlcochova, J., Besse, A., Nekvindova, J., Identification and functional screening of microRNAs highly deregulated in colorectal cancer (2012) J Cell Mol Med, 16, pp. 2655-2666
Schepeler, T., Reinert, J.T., Ostenfeld, M.S., Christensen, L.L., Silahtaroglu, A.N., Dyrskjøt, L., Diagnostic and prognostic microRNAs in stage II colon cancer (2008) Cancer Res, 68, pp. 6416-6424
Fasseu, M., Tréton, X., Guichard, C., Pedruzzi, E., Cazals-Hatem, D., Richard, C., Identification of restricted subsets of mature microRNA abnormally expressed in inactive colonic mucosa of patients with inflammatory bowel disease. Dalmasso G, editor (2010) Plos One, 5
Pizzini, S., Bisognin, A., Mandruzzato, S., Biasiolo, M., Facciolli, A., Perilli, L., Impact of microRNAs on regulatory networks and pathways in human colorectal carcinogenesis and development of metastasis (2013) BMC Genomics, 14, p. 589
Takagi, T., Naito, Y., Mizushima, K., Hirata, I., Yagi, N., Tomatsuri, N., Increased expression of microRNA in the inflamed colonic mucosa of patients with active ulcerative colitis (2010) J Gastroenterol Hepatol, 25, pp. S129-S133
Qu, Y.-L., Wang, H.-F., Sun, Z.-Q., Tang, Y., Han, X.-N., Yu, X.-B., Up-regulated miR-155-5p promotes cell proliferation, invasion and metastasis in colorectal carcinoma (2015) Int J Clin Exp Pathol, 8, pp. 6988-6994
Li, W., Han, W., Zhao, X., Wang, H., Changes of expression of miR-155 in colitis-associated colonic carcinogenesis (2014) Zhonghua Zhong Liu Za Zhi, 36, pp. 257-262
Earle, J., Luthra, R., Romans, A., Abraham, R., Ensor, J., Yao, H., Association of microRNA expression with microsatellite instability status in colorectal adenocarcinoma (2010) J Mol Diagn, 12, pp. 433-440
Wu, F., Zikusoka, M., Trindade, A., Dassopoulos, T., Harris, M.L., Bayless, T.M., MicroRNAs are differentially expressed in ulcerative colitis and alter expression of macrophage inflammatory peptide-2 alpha (2008) Gastroenterology, 135, pp. 1624–35. e24
Wu, F., Zhang, S., Dassopoulos, T., Harris, M.L., Bayless, T.M., Meltzer, S.J., Identification of microRNAs associated with ileal and colonic Crohn’s disease (2010) Inflamm Bowel Dis, 16, pp. 1729-1738
Nielsen, B.S., Jørgensen, S., Fog, J.U., Søkilde, R., Christensen, I.J., Hansen, U., High levels of microRNA-21 in the stroma of colorectal cancers predict short disease-free survival in stage II colon cancer patients (2011) Clin Exp Metastasis, 28, pp. 27-38
Lanza, G., Ferracin, M., Gafà, R., Veronese, A., Spizzo, R., Pichiorri, F., MRNA/microRNA gene expression profile in microsatellite unstable colorectal cancer (2007) Mol Cancer, 6, p. 54