[en] Atypical myopathy is ais widespread in Europe and has been suspected in Denmark but no cases have been confirmed. This study confirmed cases in this country.
Research center :
FARAH - Fundamental and Applied Research for Animals and Health - ULiège
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Høffer, Sofie Esbjørn
Votion, Dominique ; Université de Liège > Scientifiques attachés au Doyen (F MV)
Anderberg, Marie
BOEMER, François ; Centre Hospitalier Universitaire de Liège - CHU > Service de génétique
[1] Votion, D.M., Linden, A., Saegerman, C., Engels, P., Erpicum, M., Thiry, E., et al. History and clinical features of atypical myopathy in horses in Belgium (2000-2005). J Vet Intern Med 21 (2007), 1380–1391.
[2] van Galen, G., Saegerman, C., Marcillaud Pitel, C., Patarin, F., Amory, H., Baily, J.D., et al. European outbreaks of atypical myopathy in grazing horses (2006-2009): determination of indicators for risk and prognostic factors. Equine Vet J 44 (2012), 621–625.
[3] Valberg, S.J., Sponseller, B.T., Hegeman, A.D., Earing, J., Bender, J.B., Martinson, K.L., et al. Seasonal pasture myopathy/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree. Equine Vet J 45 (2013), 419–426.
[4] Westermann, C.M., de Sain-van der Velden, M.G.M., van der Kolk, J.H., Berger, R., Wijnberg, I.D., Koeman, J.P., et al. Equine biochemical multiple acyl-CoA dehydrogenase deficiency (MADD) as a cause of rhabdomyolysis. Mol Genet Metab 91 (2007), 362–369.
[5] van Galen, G., Pitel, C.M., Saegerman, C., Patarin, F., Amory, H., Baily, J.D., et al. European outbreaks of atypical myopathy in grazing equids (2006-2009): spatiotemporal distribution, history and clinical features. Equine Vet J 44 (2012), 614–620.
[6] Unger, L., Nicholson, A., Jewitt, E.M., Gerber, V., Hegeman, A., Sweetman, L., et al. Hypoglycin A concentrations in seeds of Acer pseudoplatanus trees growing on atypical myopathy-affected and control pastures. J Vet Intern Med 28 (2014), 1289–1293.
[7] Zuraw, A., Dietert, K., Kuhnel, S., Sander, J., Klopfleisch, R., Equine atypical myopathy caused by hypoglycin A intoxication associated with ingestion of sycamore maple tree seeds. Equine Vet J 48 (2016), 418–421.
[8] Votion, D.M., van Galen, G., Sweetman, L., Boemer, F., de Tullio, P., Dopagne, C., et al. Identification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy. Equine Vet J 46 (2014), 146–149.
[9] Bochnia, M., Ziegler, J., Sander, J., Uhlig, A., Schaefer, S., Vollstedt, S., et al. Hypoglycin a content in blood and urine discriminates horses with atypical myopathy from clinically normal horses grazing on the same pasture. PLoS One 10 (2015), 1–15.
[10] Ziegler, J., Abel, S., Analysis of amino acids by HPLC/electrospray negative ion tandem mass spectrometry using 9-fluorenylmethoxycarbonyl chloride (Fmoc-Cl) derivatization. Amino Acids 46 (2014), 2799–2808.
[11] Boemer, F., Deberg, M., Schoos, R., Baise, E., Amory, H., Gault, G., et al. Quantification of hypoglycin A in serum using aTRAQ® assay. J Chromatogr B Analyt Technol Biomed Life Sci 997 (2015), 75–80.
[12] Olsen, S.N., Atypical myoglobinuria in grazing horses. Helsingør, Denmark The annual meeting of the Danish horse practitioners, 2001 Poster.
[13] Votion, D.M., The story of equine atypical myopathy: a review from the beginning to a possible end. ISRN Vet Sci, 2012, 2012, 281018.
[14] Chace, D.H., Pons, R., Chiriboga, C.A., McMahon, D.J., Tein, I., Naylor, E.W., et al. Neonatal blood carnitine concentrations: normative data by electrospray tandem mass spectrometry. Pediatr Res 53 (2003), 823–829.
[15] Abaxis Inc. VetScan® Equine profile Plus Manual. 2015, 500–7138.
[16] Tanaka, K., Kean, E.A., Johnson, B., Jamaican vomiting sickness. Biochemical investigation of two cases. N Engl J Med 295 (1976), 461–467.
[17] Joskow, R., Belson, M., Vesper, H., Backer, L., Rubin, C., Ackee fruit poisoning: an outbreak investigation in Haiti 2000-2001, and review of the literature. Clin Toxicol 44 (2006), 267–273.
[18] Baise, E., Habyarimana, J.A., Amory, H., Boemer, F., Douny, C., Gustin, P., et al. Samaras and seedlings of Acer pseudoplatanus are potential sources of hypoglycin A intoxication in atypical myopathy without necessarily inducing clinical signs. Equine Vet J 48 (2016), 414–417.