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Use of Estetrol with other Steroids for Attenuation of Neonatal Hypoxic-Ischemic brain injury:to combine or not to combine?

Tskitishvili, Ekaterine; Pequeux, Christel; Munaut, Carine et al.

2016 • In Oncotarget

Peer Reviewed verified by ORBi

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https://hdl.handle.net/2268/197347

DOI
10.18632/oncotarget.9591

PubMed
27231853

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Keywords :

neonatal hypoxic-ischemic encephalopathy; hippocampus; cortex; estetrol; estradiol

Abstract :

[en] Estetrol (E4), estradiol (E2) and progesterone (P4) have important antioxidative and neuroprotective effects in neuronal system. We aimed to study the consequence of combined steroid therapy in neonatal hypoxic-ischemic encephalopathy (HIE). In vitro the effect of E4 combined with other steroids on oxidative stress and the cell viability in primary hippocampal cultures was evaluated by lactate dehydrogenase and cell survival assays. In vivo neuroprotective and therapeutic efficacy of E4 combined with other steroids was studied in HIE model of immature rats. The rat pups rectal temperature, body and brain weights were evaluated. The hippocampus and the cortex were investigated by histo/immunohistochemistry: intact cell number counting, expressions of markers for early gray matter lose, neuro- and angiogenesis were studied. Glial fibrillary acidic protein was evaluated by ELISA in blood samples. In vitro E4 and combinations of high doses of E4 with P4 and/or E2 significantly diminished the LDH activity and upregulated the cell survival. In vivo pretreatment or treatment by different combinations of E4 with other steroids had unalike effects on body and brain weight, neuro- and angiogenesis, and GFAP expression in blood. The combined use of E4 with other steroids has no benefit over the single use of E4.

Disciplines :

Pediatrics
Neurology
Reproductive medicine (gynecology, andrology, obstetrics)

Author, co-author :

Tskitishvili, Ekaterine ; Université de Liège > GIGA-Research

Pequeux, Christel ; Université de Liège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques

Munaut, Carine ; Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

VIELLEVOYE, Renaud ; Centre Hospitalier Universitaire de Liège - CHU > Service néonatologie (CHR)

Nisolle, Michelle ; Université de Liège > Département des sciences cliniques > Gynécologie - Obstétrique

Noël, Agnès ; Université de Liège > Département des sciences cliniques > Labo de biologie des tumeurs et du développement

Foidart, Jean-Michel ; Université de Liège > Département des sciences cliniques > Département des sciences cliniques

Language :

English

Title :

Use of Estetrol with other Steroids for Attenuation of Neonatal Hypoxic-Ischemic brain injury:to combine or not to combine?

Publication date :

26 May 2016

Journal title :

Oncotarget

eISSN :

1949-2553

Publisher :

Impact Journals, Albany, United States - New York

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=9591&author-preview=7ef

Available on ORBi :

since 26 May 2016

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