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Tskitishvili Ekaterine

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ORCID
0000-0003-2909-7857
Main Referenced Co-authors
Foidart, Jean-Michel  (23)
Kanagawa, Takeshi (22)
Kimura, Tadashi (19)
Tomimatsu, Takuji (19)
Noël, Agnès  (17)
Main Referenced Keywords
Estetrol (16); Female (10); Pregnancy (9); Humans (8); Adult (6);
Main Referenced Unit & Research Centers
Centre Interfacultaire de Recherche du Médicament - CIRM (2)
CIRM - Centre Interdisciplinaire de Recherche sur le Médicament - ULiège [BE] (1)
LBTD, Giga-Cancer (1)
Main Referenced Disciplines
Reproductive medicine (gynecology, andrology, obstetrics) (50)
Neurology (11)
Pediatrics (10)
Pharmacy, pharmacology & toxicology (5)
Cardiovascular & respiratory systems (1)

Publications (total 57)

The most downloaded
111 downloads
Tskitishvili, E., Pequeux, C., Munaut, C., VIELLEVOYE, R., Nisolle, M., Noël, A., & Foidart, J.-M. (2017). Estrogen receptors and estetroldependent neuroprotective actions: a pilot study. Journal of Endocrinology, 232 (1), 85-95. doi:10.1530/JOE-16-0434 https://hdl.handle.net/2268/203515

The most cited

55 citations (Scopus®)

Gérard, C., Blacher, S., Communal, L., Courtin, A., Tskitishvili, E., Mestdagt, M., Munaut, C., Noël, A., Gompel, A., Pequeux, C.* , & Foidart, J.-M.*. (2015). Estetrol is a weak estrogen antagonizing estradiol-dependent mammary gland proliferation. Journal of Endocrinology, 224 (1), 86-95. doi:10.1530/JOE-14-0549 https://hdl.handle.net/2268/174081

Tskitishvili, E., Palazzo, C., Foidart, J.-M., Piel, G., & Pequeux, C. (15 June 2023). Use of liposome-encapsulated estetrol for treatment of neonatal hypoxic-ischemic encephalopathy. Brain Research, 1809, 148369. doi:10.1016/j.brainres.2023.148369
Peer Reviewed verified by ORBi

Gallez, A., Nys, G., Wuidar, V., Dias Da Silva, I., Taziaux, M., Kinet, V., Tskitishvili, E., Noël, A., Foidart, J.-M., Piel, G., Fillet, M., & Pequeux, C. (03 June 2023). Comparison of Estetrol Exposure between Women and Mice to Model Preclinical Experiments and Anticipate Human Treatment. International Journal of Molecular Sciences, 24 (11), 9718. doi:10.3390/ijms24119718
Peer Reviewed verified by ORBi

Gallez, A.* , Palazzo, C.* , Blacher, S., Tskitishvili, E., Noël, A., Foidart, J.-M., Evrard, B., Pequeux, C.* , & Piel, G.*. (05 January 2020). Liposomes and drug-in-cyclodextrin-in-liposomes formulations encapsulating 17β-estradiol: an innovative drug delivery system that prevents the activation of the membrane-initiated steroid signaling (MISS) of estrogen receptor α. International Journal of Pharmaceutics, 573, 118861. doi:10.1016/j.ijpharm.2019.118861
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Tskitishvili, E., & Foidart, J.-M. (2019). Estetrol and its effects on the damaged brain. In R. Diaz Brinton, A. R. Genazzani, T. Simoncini, ... J. C. Stevenson (Eds.), Sex Steroids' Effects on Brain, Heart and Vessels. Springer publishing. doi:10.1007/978-3-030-11355-1_4
Peer reviewed

Foidart, J.-M., GASPARD, U., Pequeux, C., Jost, M., Gordenne, V., Tskitishvili, E., Gallez, A., Valera, M.-C., Gourdy, P., Fontaine, C., Henrion, D., Genazzani, A. R., Lenfant, F., & Arnal, J.-F. (2019). Unique Vascular Benefits of Estetrol, a Native Fetal Estrogen with Specific Actions in Tissues (NEST). In R. Diaz Brinton, A. Genazzani, T. Simoncini, ... J. Stevenson, Sex Steroids' Effects on Brain, Heart and Vessels: Volume 6: Frontiers in Gynecological Endocrinology. Cham, Switzerland: Springer Nature. doi:10.1007/978-3-030-11355-1
Peer reviewed

Tskitishvili, E., Pequeux, C., VIELLEVOYE, R., Nisolle, M., Noël, A., & Foidart, J.-M. (13 November 2018). Estetrol, a newly designated orphan drug, for attenuation of neonatal Hypoxic-Ischemic Encephalopathy (HIE) [Poster presentation]. "From Rare to Care: Discovery, Modeling and Translation of Rare Diseases", Vienna, Austria.

Tskitishvili, E., Pequeux, C., Munaut, C., VIELLEVOYE, R., NISOLLE, M., Noël, A., & Foidart, J.-M. (20 October 2017). ESTROGEN RECEPTORS AND ESTETROL-DEPENDENT NEUROPROTECTIVE ACTIONS: A PILOT STUDY [Paper presentation]. The 12th International Congress of the European Society of Gynecology, Barcelona, Spain.

Tskitishvili, E., Pequeux, C., Munaut, C., VIELLEVOYE, R., Nisolle, M., Noël, A., & Foidart, J.-M. (2017). Estrogen receptors and estetroldependent neuroprotective actions: a pilot study. Journal of Endocrinology, 232 (1), 85-95. doi:10.1530/JOE-16-0434
Peer Reviewed verified by ORBi

Tskitishvili, E., Nisolle, M., Noël, A., & Foidart, J.-M. (17 June 2016). Estetrol Attenuates Neonatal Hypoxic-Ischemic Encephalopathy: Preclinical Studies [Poster presentation]. The 25th European Congress of Perinatal Medicine, Maastricht, Netherlands.

Tskitishvili, E., Pequeux, C., Munaut, C., VIELLEVOYE, R., Nisolle, M., Noël, A., & Foidart, J.-M. (2016). Use of Estetrol with other Steroids for Attenuation of Neonatal Hypoxic-Ischemic brain injury:to combine or not to combine? Oncotarget. doi:10.18632/oncotarget.9591
Peer Reviewed verified by ORBi

Tskitishvili, E., VIELLEVOYE, R., Gérard, C., Pequeux, C., Munaut, C., Nisolle, M., Noël, A., & Foidart, J.-M. (May 2016). Neonatal Hypoxic-Ischemic Encephalopathy: a new view of an old problem. Références en Gynécologie Obstétrique, 17 (1-1).
Peer reviewed

Tskitishvili, E., Nisolle, M., Noël, A., & Foidart, J.-M. (2016). Estetrols’ Potential for Neuroprotection Following the injury to the Developing Brain: Preclinical Studies. In The 17th World Congress of Gynecological Endocrinology, Florence 2-5 March 2016.

Tskitishvili, E. (2016). Editor’s Note: Women’s Health Care. Journal of Women's Health Care, 5 (5). doi:10.4172/2167-0420.1000e126
Peer reviewed

Palazzo, C., Karim, R., Furst, T., Pequeux, C., Tskitishvili, E., Mawet, M., Maillard, C., Foidart, J.-M., Evrard, B., & Piel, G. (25 October 2015). LIPOSOME ENCAPSULATING ESTETROL FOR THE TREATMENT OF ISCHEMIA DISEASES IN PREMATURE BABIES [Poster presentation]. 2015 AAPS Annual Meeting and Exposition, Orlando, FLA, United States.

Palazzo, C., Karim, R., Pequeux, C., Tskitishvili, E., Mawet, M., Maillard, C., Foidart, J.-M., Evrard, B., & Piel, G. (02 June 2015). Liposome Encapsulating Estetrol For The Treatment Of Ischemia Diseases In Prematures Babies [Poster presentation]. Biomedica 2015, Genk, Belgium.

Gérard, C., Mestdagt, M., Tskitishvili, E., Communal, L., Gompel, A., Silva, E., Arnal, J.-F., Lenfant, F., Noël, A., Foidart, J.-M., & Pequeux, C. (2015). Combined estrogenic and anti-estrogenic properties of estetrol on breast cancer may provide a safe therapeutic window for the treatment of menopausal symptoms. Oncotarget. doi:10.18632/oncotarget.4184
Peer Reviewed verified by ORBi

Tskitishvili, E., Nisolle, M., Noël, A., & Foidart, J.-M. (2015). ESTETROL AND ITS NEUROPROTECTIVE EFFECT IN NEONATAL HYPOXIC-ISCHEMIC ENCEPHALOPATHY. In The 12th World Congress of Perinatal Medicine, Madrid, 3-6 November 2015.
Peer reviewed

Gérard, C., Blacher, S., Communal, L., Courtin, A., Tskitishvili, E., Mestdagt, M., Munaut, C., Noël, A., Gompel, A., Pequeux, C.* , & Foidart, J.-M.*. (2015). Estetrol is a weak estrogen antagonizing estradiol-dependent mammary gland proliferation. Journal of Endocrinology, 224 (1), 86-95. doi:10.1530/JOE-14-0549
Peer Reviewed verified by ORBi
* These authors have contributed equally to this work.

Tskitishvili, E., Nisolle, M., Noël, A., & Foidart, J.-M. (2015). Hypoxic-Ischemic Encephalopathy and Premature Babies Brain Damage: Impact of Estetrol. In The 11th Congress of the European Society of Gynecology, Prague 21-24 October, 2015.
Peer reviewed

Pequeux, C., & Tskitishvili, E. (27 November 2014). Estrogens and neonatal neuroprotection [Paper presentation]. SAB-GIGA-Cancer.

Tskitishvili, E., Nisolle, M., Munaut, C., Pequeux, C., Gérard, C., Noël, A., & Foidart, J.-M. (November 2014). Estetrol attenuates neonatal hypoxic–ischemic brain injury. Experimental Neurology, 261, 298-307. doi:10.1016/j.expneurol.2014.07.015
Peer Reviewed verified by ORBi

Tskitishvili, E., Noël, A., & Foidart, J.-M. (24 July 2014). In Search of New First Trimester Biomarkers for Ischemic Placental Disease. Austin Journal of Obstetrrics and Gynecology, 1 (2), 1-3.
Peer reviewed

Tskitishvili, E., Nisolle, M., Noël, A., & Foidart, J.-M. (2014). Estetrol and neuroprotection against perinatal ischemic insult. In Estetrol attenuates neonatal hypoxic-ischemic brain injury.
Peer reviewed

Tskitishvili, E. (14 November 2013). E4 and neonatal neural protection [Paper presentation]. SAB Estetra-Estetrol.

Foidart, J.-M., & Tskitishvili, E. (24 October 2013). Estrogenic components for use in the treatment of neurological disorders.

Tskitishvili, E., Nisolle, M., Noël, A., & Foidart, J.-M. (2013). Estetrol: a new fetal estrogen with antioxidative and neuroprotective activity in the newborn. In Estetrol attenuates neonatal hypoxic-ischemic brain injury.
Peer reviewed

Tskitishvili, E. (2013). Etude de l’estetrol dans les organes endocrino-sensibles.

Temma-Asano, K., Tskitishvili, E., Kanagawa, T., Tomimatsu, T., Tsutsui, T., Kimura, T., Chang, Y. S., Nakamura, T., Nakai, Y., & Shimoya, K. (2011). Effects of 4-Hydroxy-2-Nonenal, a Major Lipid Peroxidation-Derived Aldehyde, and N-Acetylcysteine on the Cyclooxygenase-2 Expression in Human Uterine Myometrium. Gynecologic and Obstetric Investigation. doi:10.1159/000322393
Peer Reviewed verified by ORBi

Tskitishvili, E. (01 March 2010). Tumor-associated antigen RCAS1 and its role in pregnancies complicated by pre-eclampsia [Paper presentation]. Invited Seminar, Liege, Belgium.

Tskitishvili, E., Sharentuya, N., Tsubouchi, H., Kinugasa-Taniguchi, Y., Kanagawa, T., Shimoya, K., Tomimatsu, T., & Kimura, T. (2010). Maternal Blood Serum and Plasma Human Tumor-Associated Antigen RCAS1 During the Course of Uncomplicated Pregnancies: A Prospective Study. American Journal of Reproductive Immunology, 64 (3), 218-24. doi:10.1111/j.1600-0897.2010.00859.x
Peer Reviewed verified by ORBi

Tskitishvili, E., Sharentuya, N., Temma-Asano, K., Mimura, K., Kinugasa-Taniguchi, Y., Kanagawa, T., Fukuda, H., Kimura, T., Tomimatsu, T., & Shimoya, K. (2010). Oxidative stress-induced S100B protein from placenta and amnion affects soluble Endoglin release from endothelial cells. Molecular Human Reproduction, 16 (3), 188-99. doi:10.1093/molehr/gap104
Peer Reviewed verified by ORBi

Tskitishvili, E. (2010). RCAS1 protein as a new biomarker for early prediction of pre-eclampsia? Osaka, Japan: JSPS.

Mimura, K., Tomimatsu, T., Sharentuya, N., Tskitishvili, E., Kinugasa-Taniguchi, Y., Kanagawa, T., & Kimura, T. (2010). Nicotine restores endothelial dysfunction caused by excess sFlt1 and sEng in an in vitro model of preeclamptic vascular endothelium: a possible therapeutic role of nicotinic acetylcholine receptor (nAChR) agonists for preeclampsia. American Journal of Obstetrics and Gynecology, 202 (5), 464.e1-6. doi:10.1016/j.ajog.2010.01.037
Peer Reviewed verified by ORBi

Tskitishvili, E., Nakamura, H., Kinugasa-Taniguchi, Y., Kanagawa, T., Shimoya, K., Tomimatsu, T., & Kimura, T. (2010). The effect of tumor-associated protein RCAS1 gene silencing on blood pressure and urinary protein excretion in pregnant mouse: a pilot study. American Journal of Obstetrics and Gynecology, 203 (4), 364.e6-364.e12. doi:10.1016/j.ajog.2010.05.015
Peer Reviewed verified by ORBi

Tskitishvili, E., Nakamura, H., Kinugasa-Taniguchi, Y., Kanagawa, T., Kimura, T., Tomimatsu, T., & Shimoya, K. (2010). Temporal and spatial expression of tumor-associated antigen RCAS1 in pregnant mouse uterus. American Journal of Reproductive Immunology, 63 (2), 137-43. doi:10.1111/j.1600-0897.2009.00772.x
Peer Reviewed verified by ORBi

Sharentuya, N., Tomimatsu, T., Mimura, K., Tskitishvili, E., Kinugasa-Taniguchi, Y., Kanagawa, T., & Kimura, T. (2010). Nicotine suppresses interleukin-6 production from vascular endothelial cells: a possible therapeutic role of nicotine for preeclampsia. Reproductive Sciences, 17 (6), 556-63. doi:10.1177/1933719110362594
Peer Reviewed verified by ORBi

Tskitishvili, E., Tomimatsu, T., Kanagawa, T., Sawada, K., Kinugasa, Y., Mimura, K., & Kimura, T. (2009). Amniotic fluid 'sludge' detected in patients with subchorionic hematoma: a report of two cases. Ultrasound in Obstetrics and Gynecology, 33 (4), 484-6. doi:10.1002/uog.6348
Peer Reviewed verified by ORBi

Tskitishvili, E., Sharentuya, N., Temma-Asano, K., Tomimatsu, T., Kinugasa-Taniguchi, Y., Kanagawa, T., Kimura, T., & Shimoya, K. (2009). Possible connection between sEndoglin and S100B protein might lead to the development of endothelial dysfunction and preeclampsia [Poster presentation]. 3rd SGI International Summit 2009 dedicated to Preeclampsia, Sendai, Japan.

Mimura, K., Tomimatsu, T., Sharentuya, N., Tskitishvili, E., Kinugasa-Taniguchi, Y., Kanagawa, T., & Kimura, T. (2009). Nicotine restores endothelial dysfunction caused by excess sFLT1 and sEng in in vitro model pf preeclamptic vascular endothelium [Poster presentation]. 3rd SGI International Summit 2009 dedicated to Preeclampsia, Sendai, Japan.

Tomimatsu, T., Sharentuya, N., Mimura, K., Tskitishvili, E., Kinugasa-Taniguchi, Y., Kanagawa, T., & Kimura, T. (2009). Nicotine suppresses interleukin-6 production from vascular endothelial cells [Poster presentation]. 3rd SGI International Summit 2009 dedicated to Preeclampsia, Sendai, Japan.

Sarun, T., Tomimatsu, T., Mimura, K., Kanagawa, T., Kinugasa, Y., Tskitishvili, E., & Kimura, T. (2009). Can Nicotine become the remedy for the Pregnancy Induced Hypertension Syndrome?-A basic Research- [Poster presentation]. 61st Annual Congress of the Japan Society of Obstetrics and Gynecology, Kyoto, Japan.

Tskitishvili, E., Komoto, Y., Kinugasa, Y., Kanagawa, T., Song, M., Mimura, K., Tomimatsu, T., Kimura, T., & Shimoya, K. (2008). The human tumor-associated antigen RCAS1 in pregnancies complicated by pre-eclampsia. Journal of Reproductive Immunology, 77 (1), 100-8. doi:10.1016/j.jri.2007.05.001
Peer Reviewed verified by ORBi

Tskitishvili, E., Komoto, Y., Kinugasa, Y., Kanagawa, T., Mimura, K., Song, M., Tomimatsu, T., Kimura, T., & Shimoya, K. (2007). The maternal blood serum human tumor-associated protein RCAS1 in pregnancies complicated by gestational diabetes mellitus [Poster presentation]. 20th Asian and Oceanic Congress of Obstetrics and Gynecology, Tokyo, Japan.

Kanagawa, T., Tomimatsu, T., Mimura, K., Katayama, M., Kinugasa, Y., Tskitishvili, E., & Kimura, T. (2007). The effect of hypothermia on neonatal stem cells [Poster presentation]. 43d Conference of the Japan Society of Perinatal and Neonatal Medicine, Tokyo, Japan.

Kinugasa, Y., Mimura, K., Katayama, M., Tskitishvili, E., Kanagawa, T., Tomimatsu, T., & Kimura, T. (2007). The role of CRP on neonatal hypoxic-ischemic encephalopathy [Poster presentation]. 43d Conference of the Japan Society of Perinatal and Neonatal Medicine, Tokyo, Japan.

Tskitishvili, E., Komoto, Y., Kinugasa, Y., Kanagawa, T., Song, M., Mimura, K., Tomimatsu, T., Kimura, T., & Shimoya, K. (2007). Relationship between human tumor-associated antigen RCAS1 and gestational diabetes mellitus [Poster presentation]. 23d Annual Meeting of the Japanese Society of Diabetes and Pregnancy, Osaka, Japan.

Tskitishvili, E., Mimura, K., Kinugasa, Y., Kanagawa, T., Tomimatsu, T., Kimura, T., Song, M., & Shimoya, K. (2007). The tumor-associated RCAS1 protein:a contemporary view about pre-eclampsia? [Poster presentation]. 43d Conference of the Japan Society of Perinatal and Neonatal Medicine, Tokyo, Japan.

Tskitishvili, E., Komoto, Y., Kinugasa, Y., Kanagawa, T., Song, M., Mimura, K., Tomimatsu, T., Kimura, T., & Shimoya, K. (2007). Relationship between human tumor-associated antigen RCAS1 and gestational diabetes mellitus. American Journal of Reproductive Immunology, 58 (5), 440-6. doi:10.1111/j.1600-0897.2007.00528.x
Peer Reviewed verified by ORBi

Tskitishvili, E., Komoto, Y., Kinugasa, Y., Kanagawa, T., Song, M., Mimura, K., Tomimatsu, T., Kimura, T., & Shimoya, K. (2007). Level of S100B protein expression in the amnion at various gestational ages in the third trimester of normal pregnancies. Acta Obstetricia et Gynecologica Scandinavica, 86 (8), 915-20. doi:10.1080/00016340701434427
Peer Reviewed verified by ORBi

Tskitishvili, E., Komoto, Y., Temma-Asano, K., Hayashi, S., Kinugasa, Y., Tsubouchi, H., Song, M., Kanagawa, T., Shimoya, K., & Murata, Y. (2006). S100B protein expression in the amnion and amniotic fluid in pregnancies complicated by pre-eclampsia. Molecular Human Reproduction, 12 (12), 755-61. doi:10.1093/molehr/gal083
Peer Reviewed verified by ORBi

Tsubouchi, H., Shimoya, K., Song, M., Kinugasa, Y., Hayashi, S., Tskitishvili, E., Komoto, Y., Temma-Asano, K., Kanagawa, T., & Murata, Y. (2006). Maternal stress markers during pregnancy [Poster presentation]. 42d Conference of the Japan Society of Perinatal and Neonatal Medicine, Miyazaki, Japan.

Fukui, O., Kinugasa, Y., Fukuda, A., Fukuda, H., Tskitishvili, E., Hayashi, S., Song, M., Kanagawa, T., Hosono, T., Shimoya, K., & Murata, Y. (2006). Post-ischemic hypothermia reduced IL-18 expression and suppressed microglial activation in the immature brain. Brain Research, 1121 (1), 35-45. doi:10.1016/j.brainres.2006.08.121
Peer Reviewed verified by ORBi

Shimoya, K., Komoto, Y., Temma-Asano, K., Tskitishvili, E., Hayashi, S., Fukui, O., Tsubouchi, H., Fukuda, H., Shioji, M., Wasada, K., & Murata, Y. (2005). Association between S100B protein levels in the amniotic fluid and preeclampsia [Poster presentation]. 7th World Congress of Perinatal Medicine, Zagreb, Croatia.

Temma-Asano, K., Shimoya, K., Tskitishvili, E., Hayashi, S., Komoto, Y., Fukui, O., Shioji, M., Fukuda, H., Wasada, K., & Murata, Y. (2005). Oxidative stress which occurs during chorioamnionitis induces production of prostaglandins by uterus [Poster presentation]. 41st Conference of the Japan Society of Perinatal and Neonatal Medicine, Fukuoka, Japan.

Komoto, Y., Shimoya, K., Tskitishvili, E., Tsubouchi, H., Hayashi, S., Fukui, O., Shioji, M., Fukuda, H., Wasada, K., & Murata, Y. (2005). The study of S100B protein in patients with pre-eclampsia and IUGR [Poster presentation]. 41st Conference of the Japan Society of Perinatal and Neonatal Medicine, Fukuoka, Japan.

Tskitishvili, E. (1994). Variation of the Alkaline Phosphataze in the blood during Gestosis [Paper presentation]. TSMU Student Conference, Tbilisi, Georgia.

Tskitishvili, E. (1992). Radiodiagnostic algorithm of the thyroid gland's nodule formation [Paper presentation]. TSMU Student Conference, Tbilisi, Georgia.

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